[Clinical research in service of clinical medicine: Contexts, practice, methodology and theory of Paul Martinís "clinical proof" - part 3: Causally relevant elements of Martini's clinical proof and epistemological remarks].

In the third part of our quadripartite series on Paul Martini and his concept of clinical proof we shortly present the mostly procedural elements of his test of treatment. We discuss their causal conduciveness: what do they contribute to infer causality from effect? Finally we comment on some of Martini's epistemological assumptions and methodological decisions that underpin his method of proof.

[The Migration and Health Teaching Network: consolidating and developing education and training].

Patients with migration history often encounter barriers to accessing healthcare in Germany, which lowers the quality of care available to them and can affect their overall health. These barriers in access to healthcare are due to both adverse health policies and a lack of migration-related - and diversity-sensitive - content in medical and other health profession teaching. Although most healthcare professionals regularly care for patients with individual or generational migration experience in Germany, teaching content relevant to the healthcare of these patients has not yet been anchored in the curriculum.

[The Catholic world and urology in the 20th/21st century].

The Catholic world is shaped by papal directives and their interpretation over time by appointed theologians. There are strict prohibitions on key questions about life and death, but in the context of the practical application of medical treatment techniques, the Vatican often remains vague. This may allow Catholic urologists to use a range of therapies that at first glance appear problematic.

[Early origins of a physician specializing in sexual medicine from the urological perspective : Max Marcuse (1877-1963)-"physician for skin and urinary diseases"].

The development of sexual medicine starts in Europe in parallel to the evolving clinical specialties urology, venerology, gynecology, neurology/psychiatry, and internal medicine at the end of the 19th century in Berlin. For this reason, we find many examples of fruitful collaboration but also in segregation from each other in defining the new specialties. Max Marcuse, the only one of the well-known Berlin specialists Ivan Bloch, Magnus Hirschfeld, and Albert Moll to survive the Holocaust, was able to publish articles in Palestine and Israel from the 1930s to the 1960s.

[Carl Arthur Kollmann: urologist, venereologist and puppeteer from Leipzig].

While Felix Martin Oberländer (born in Dresden, Saxony, Germany) is remembered in German-speaking urology and abroad, and his name has been honored since 1997 with an award named after him, the memory and knowledge of Arthur Kollmann of Leipzig (Saxony, Germany) seems to have been nearly forgotten within urology in Germany and abroad. However, the memory of him in other fields of science in which he was involved, e.g.

The revised International Code of Medical Ethics: an exercise in international professional ethical self-regulation.

The World Medical Association (WMA), the global representation of the medical profession, first adopted the International Code of Medical Ethics (ICoME) in 1949 to outline the professional duties of physicians to patients, other physicians and health professionals, themselves and society as a whole. The ICoME recently underwent a major 4-year revision process, culminating in its unanimous adoption by the WMA General Assembly in October 2022 in Berlin. This article describes and discusses the ICoME, its revision process, the controversial and uncontroversial issues, and the broad consensus achieved among WMA constituent members, representing over 10 million physicians worldwide.

[New research issues in the history of German sexology and sexual medicine].

New research questions in the history of German sexology and sexual medicine include a new look at the Imperial and the Weimar Republic periods and Magnus Hirschfeld as a protagonist, as well as the contemporary history of the discipline in the Federal Republic with the two formative institutes in Frankfurt (Volkmar Sigusch) and Hamburg (Eberhard Schorsch). In the post-war period, the tendency to try to solve social problems through endocrinological and surgical approaches continued. This included the (voluntary) castration of sex offenders, which has been regulated by law in the West Germany since 1969.

[Changes in the routine work and moral distress in psychiatric care during the COVID-19 pandemic : A survey among physicians active in inpatient care in Germany].

Background: During the COVID-19 pandemic a number of ethical challenges have arisen in the healthcare system. A psychological response to moral challenges is termed moral distress (MD).

Objective: Identification of causes of MD in inpatient psychiatric care in the context of the COVID-19 pandemic in Germany.

[Simulation of mortality after different ex-ante and ex-post-triage methods in people with disabilities and comorbidities].

The significant increase in patients during the COVID-19 pandemic presented the healthcare system with a variety of challenges. The intensive care unit is one of the areas particularly affected in this context. Only through extensive infection control measures as well as an enormous logistical effort was it possible to treat all patients requiring intensive care in Germany even during peak phases of the pandemic, and to prevent triage even in regions with high patient pressure and simultaneously low capacities.

["No discussions about discharge of semen!" : The wild life of the urologist Felix Schlagintweit (1868-1950)].

Felix Schlagintweit worked in a medical clinic, was co-owner of a sanatorium, had a private practice and wrote fictional books. He massively improved diagnostic methods (e.g.

[Clinical research in service of clinical medicine: Contexts, practice, methodology and theory of Paul Martini's "clinical proof" - part 2: Martini's early therapeutic research].

This article aims to examine Paul Martini's early therapeutic research. It traces the development and early practice of his methodology by focussing on four clinical studies which Martini conducted in the years 1928 to 1932. The studies show a methodological transition from uncontrolled drug evaluation to systematic method-based drug testing and the production of increasingly valid results.

[German "Triage Act"-Regulation with fatal consequences].

With the coming into force of § 5c of the Infection Protection Act (IfSG), the so-called Triage Act, on 14 December 2022, a protracted discussion has come to a provisional conclusion, the result of which physicians and social associations but also lawyers and ethicists are equally dissatisfied. The explicit exclusion of the discontinuation of treatment that has already begun in favor of new patients with better chances of success (so-called tertiary or ex-post triage) prevents allocation decisions with the aim of enabling as many patients as possible to beneficially participate in medical care under crisis conditions. The result of the new regulation is de facto a first come first served allocation, which is associated with the highest mortality even among individuals with limitations or disabilities and was rejected by a large margin as unfair in a population survey.

[Public mental health and patient autonomy-an area of conflict?].

Public mental health (PMH) interventions aim to promote and improve the well-being of members of a society. PMH is based on a normative understanding of what well-being is and what factors contribute to it. Without necessarily disclosing it, measures of a PMH program may affect the autonomy of individuals if their personal perceptions regarding their own individual well-being differ from PMH's prescriptions for well-being oriented toward societal goals.

[The genesis of informed consent in the context of medical research ethics 1900-1931].

At the turn of the 20th century, the problem of human experimentation and the need to obtain consent became more important among medical practitioners and the general public. The case of the venereologist Albert Neisser, among others, is used to trace the development of research ethics standards in Germany between the end of the 19th century and 1931. The concept of informed consent, which originated in research ethics, is also of central importance in clinical ethics today.

Deciphering regeneration through non-model animals: A century of experiments on cephalopod mollusks and an outlook at the future.

The advent of marine stations in the last quarter of the 19th Century has given biologists the possibility of observing and experimenting upon myriad marine organisms. Among them, cephalopod mollusks have attracted great attention from the onset, thanks to their remarkable adaptability to captivity and a great number of biologically unique features including a sophisticate behavioral repertoire, remarkable body patterning capacities under direct neural control and the complexity of nervous system rivalling vertebrates. Surprisingly, the capacity to regenerate tissues and complex structures, such as appendages, albeit been known for centuries, has been understudied over the decades.

[Richard Semon (1859-1918): expeditions, engrams and epigenetics].

Richard Semon (1859-1918) was a student of Ernst Haeckel and began his career as a zoologist with work on sea urchins, starfish, chicken and lung fish, which he collected at the Mediterranean Sea and in Australia. After his return to Germany he was forced to leave Jena and the university due to private reasons, and settled in Munich, where Semon devoted most of his time to the more philosophical aspects of biology, developed the theory of "mneme" (1904), which he extended towards the inheritance of acquired characteristics (1912). Semon's concept of memory reached far beyond the brain and the individual person.

[O vos mendici medici. Criticism of medical doctors by Johannes Gregor Macer Szepsius (ca. 1530-after 1579)].

A relationship between literature and medicine has existed since antiquity. A physician often appears in the literary genre of satire as the representative of medicine and is the object of the satire. The barely known humanistic author Johannes Gregor Macer Szepsius (ca.

Artificial Intelligence in Reproductive Medicine - An Ethical Perspective.

Artificial intelligence is steadily being integrated into all areas of medicine. In reproductive medicine, artificial intelligence methods can be utilized to improve the selection and prediction of sperm cells, oocytes, and embryos and to generate better predictive models for in vitro fertilization. The use of artificial intelligence in this field is justified by the suffering of persons or couples who wish to have children but are unable to conceive.

[Gentle hands bring relief. Thure Brandt's massage as a contemporary document and starting aid for urology].

Naturopathy and urology have little overlap in the present day, but in the Victorian era it was genital massage that made it clear to the medical profession that training specialized in diseases of the abdomen was necessary for physicians, otherwise patients would seek out lay healers and not clinics. This massage was developed in the 1850s by the Swedish officer Thure Brandt. It remained part of German medical practice until after World War II.

[Clinical research in service of clinical medicine: Contexts, practice, methodolody, and theory of Paul Marini's "clinical proof" - part 1].

This is the first contribution to a quadripartite series on Paul Martini, internist and early clinical epidemiologist (1889-1964), and his clinical proof ("klinischer Beweis"). Following a historical introduction and the presentation of our programme, the text deals with Martini as a person and his socio-cultural background between the end of the Great War and the 1960s. It throws light on his original, innovative and risky research programme, and outlines various factors which led Martini to his central life issue: the therapeutic-clinical proof based on controlled investigations.

[From Nazi to Hitler Analyst: The Autobiographical Reinterpretations of the Psychiatrist Johann Recktenwald (1882-1964)].

Aim Of The Study: The focus of this article is the psychiatrist Johann Recktenwald (1882-1964) who has so far received little attention: acquitted of the charge of "crimes against humanity", he went public in post-war Germany with a neuropsychiatric treatise on Hitler. But is this appearance as a Hitler-critical psychiatrist consistent with the available historical sources? What was Recktenwald's relationship with the Nazi regime, and how did he behave in the "Third Reich" towards the patients entrusted to his care?

Methods: The paper is largely based on documents from various archives, some of which have been evaluated for the first time, and on court records. The latter are supplemented and compared with the writings of Recktenwald and the available secondary literature.