1,315 results match your criteria: "Germinoma Central Nervous System"
Massive intratumoral hemorrhage following ventriculoperitoneal shunting procedure in an 8-year-old boy: A case report.
Surg Neurol Int
November 2024
Department of Neurosurgery, Dr. Soetomo General Hospital/Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia.
Background: Pineal region tumors comprise 0.4% of all central nervous system tumors in adults and 2.8% in children aged up to 19 years.
View Article and Find Full Text PDFIntracranial lobar germinoma presenting with refractory hypernatremia.
Childs Nerv Syst
December 2024
Department of Neuro-Intervention and Neuroradiology, National Institute of Mental Health & Neurosciences (NIMHANS), 29, Bengaluru, Karnataka, 560029, India.
Article Synopsis
- * A case study reports a 14-year-old boy diagnosed with diabetes insipidus, initially thought to have a high-grade glioma in the left frontal region, but was later confirmed to have a germinoma through histopathology.
- * Post-surgery, the patient experienced improvement in his hypernatremia and successfully managed his condition with a small dose of desmopressin, highlighting the unique presentation of this germinoma without typical involvement in key brain regions.
High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors.
Acta Neuropathol Commun
November 2024
Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Article Synopsis
- * This study aimed to assess the detectability of circulating-tumor DNA (ctDNA) in cerebrospinal fluid (CSF) as a biomarker for monitoring CNS-GCT patients.
- * Results showed that ctDNA could be detected in 89% of diagnostic samples, indicating its potential for non-invasive diagnosis and treatment response monitoring in future CNS-GCT research.
Article Synopsis
- The study aimed to investigate how social determinants of health (SDoH), specifically socioeconomic status using the Yost Index, affect disparities in care and outcomes for pediatric CNS tumors in the US.
- Researchers conducted a retrospective analysis of data from over 18,000 patients aged 19 or younger with CNS tumors from 2010-2018, analyzing various demographic and treatment-related factors.
- Results indicated significant disparities in mortality risks, treatment accessibility, delays, and cancer staging related to certain SDoH factors, suggesting that both individual and community-level influences play a critical role in health outcomes for these patients.
Pituitary stalk thickening in pediatric patients: an underrecognized diagnosis?
Arch Endocrinol Metab
October 2024
Instituto de Neurocirugía Asenjo Santiago Chile Instituto de Neurocirugía Asenjo, Santiago, Chile.
Article Synopsis
Seminoma characterized by thickening of the pituitary stalk A case report.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Department of Endocrinology, First Affiliated Hospital of Army Medical University, Chongqing 400038.
Article Synopsis
- Intracranial seminoma is a rare type of cancer that starts in special cells in the brain, often found in the pineal or pituitary gland.
- A 20-year-old patient had headaches and vision problems and was diagnosed with this cancer after an MRI showed issues with his pituitary stalk.
- He had surgery to remove the tumor and received treatment, but it came back a year later, leading to another surgery and ongoing treatments, although he still faces some health challenges.
Consensus guidelines for the management of pineal region tumours for low- and middle-income countries.
J Pak Med Assoc
March 2024
Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
Article Synopsis
- * These tumors often cause obstructive hydrocephalus and symptoms such as headaches, nausea, and impaired gait due to mass effect.
- * Diagnosis primarily relies on imaging, while biopsy is required for histologic confirmation, except for germinomas, which can be identified through specific tumor markers; treatments vary from surgery for benign tumors to additional chemotherapy and radiotherapy for malignant ones.
Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up.
J Neurooncol
October 2024
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai, 980-8574, Japan.
Purpose: This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory and association with stroke in patients with germinoma who had long-term follow-up were evaluated.
Methods: This study included 64 patients with germinoma who were histologically and clinically diagnosed with and treated for germinoma.
Acute toxicity of chemotherapy in central nervous system germ cell tumour patients according to age.
Front Oncol
July 2024
Department of Pediatric Oncology, Institut d'Hémato-oncologie Pédiatrique, Lyon, France.
Article Synopsis
- - The SIOP-CNS-GCT-II European trial studied the effects of age on acute toxicity from chemotherapy in patients with central nervous system germ cell tumors, using various chemotherapy regimens based on tumor type.
- - Analysis included 296 patients across three age groups: children (≤11 years), adolescents (12-17 years), and adults (≥18 years), revealing that adults experienced lower rates of severe adverse events compared to adolescents despite similar chemotherapy dosages.
- - The study concluded that adults can safely tolerate intensive chemotherapy protocols with less toxicity than adolescents, indicating a need for further investigation into how age influences chemotherapy-related toxicity.
Primary central nervous system germ cell tumors in Central America and the Caribbean Region: an AHOPCA 20-year experience.
Front Oncol
July 2024
Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Article Synopsis
Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm.
Childs Nerv Syst
November 2024
Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, Edinburgh, UK.
Purpose: This retrospective systematic literature review aimed to summarize available data regarding epidemiology, etiology, presentation, investigations, differentials, treatment, prevention, monitoring, complications, and prognosis for radiation-induced cavernous malformations (RICMs) in pediatric patients.
Methodology: Review conducted per PRISMA guidelines. Google Scholar, PubMed, Trip Medical Database, and Cochrane Library searched utilizing a keyphrase, articles filtered per inclusion/exclusion criteria, duplicates excluded.
Clinical effects of neuroendoscopic infratentorial supracerebellar approach surgical technique for resecting pineal tumors: a retrospective study.
Neurochirurgie
September 2024
Department of Neurosurgery, Second Hospital of Lanzhou University, Lanzhou 730030, China. Electronic address:
Article Synopsis
- Pineal tumors are rare brain growths, mostly found in kids, and this article studies a special surgical method to remove them.
- The study looked at nine patients who had surgery using a technique called neuroendoscopy to take out tumors from the pineal area between 2017 and 2023.
- After the surgeries, all patients were okay, with no tumors coming back, although some had minor vision and walking problems; but they all lived normal lives after a few years.
Long-term outcomes following proton therapy for non-metastatic central nervous system germinoma in children and adolescents.
Radiother Oncol
September 2024
Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL, United States.
Article Synopsis
- The study examines the use of proton therapy (PT) for treating pure germinoma in children and adolescents, highlighting its ability to spare normal tissue and reduce side effects compared to traditional radiation methods.
- A total of 35 non-metastatic patients participated, with a treatment plan involving chemotherapy and targeted radiation, resulting in excellent local control and survival rates over a median follow-up of 6.2 years.
- The findings suggest that PT is highly effective with minimal serious side effects, indicating a need for further research on optimizing radiation doses to improve treatment outcomes.
Imaging in malignant germ cell tumors involving the hypothalamo-neurohypophyseal axis: the evaluation of the posterior pituitary bright spot is essential.
Neuroradiology
August 2024
Department of Neuroradiology, University Hospital Wuerzburg, Josef-Schneider-Strasse 11, D-97080, Wuerzburg, Germany.
Purpose: Malignant intracranial germ cell tumors (GCTs) are rare diseases in Western countries. They arise in midline structures and diagnosis is often delayed. We evaluated imaging characteristics and early tumor signs of suprasellar and bifocal GCT on MRI.
View Article and Find Full Text PDFPrognostic implications of distinctive imaging characteristics in primary intracranial germ cell tumors: A retrospective analysis.
J Formos Med Assoc
May 2024
Department of Medical Imaging, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei City, 100, Taiwan, ROC. Electronic address:
Article Synopsis
A case of a pineal parenchymal tumor of intermediate differentiation with bifocal lesions differentiated by negative placental alkaline phosphatase in the spinal fluid.
Childs Nerv Syst
September 2024
Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan.
Article Synopsis
- Scientists found that checking for a special protein called PLAP in the spinal fluid helps doctors figure out if a patient has a specific type of brain tumor called a germinoma.
- They looked at a 15-year-old boy who had tumors in two places in his brain, but tests showed he didn’t have that protein, making them think it might be a different kind of tumor.
- After doing some surgery to remove the tumors, they discovered it was a less common type called a pineal parenchymal tumor, teaching doctors that PLAP can help tell different tumors apart for better treatment.
Evolution of Surgical Management of Pineal Region Tumors in the Pediatric Population: A 17-Year Experience at a Single Institution.
Pediatr Neurosurg
July 2024
Department of Neurosurgery, Children's National Hospital, Washington, District of Columbia, USA.
Article Synopsis
Whole-exome sequencing has revealed novel genetic characteristics in intracranial germ cell tumours in the Chinese.
Histopathology
June 2024
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Aims: Intracranial germ cell tumour (IGCT) is a type of rare central nervous system tumour that mainly occurs in children and adolescents, with great variation in its incidence rate and molecular characteristics in patients from different populations. The genetic alterations of IGCT in the Chinese population are still unknown.
Methods And Results: In this study, 47 patients were enrolled and their tumour specimens were analysed by whole-exome sequencing (WES).
Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study.
Indian J Pathol Microbiol
April 2024
Department of Pathology, Regional Cancer Centre, Trivandrum, Kerala, India.
Context: Central nervous system germ cell tumors (CNSGCTs) though rare is the second most common extragonadal site for GCTs.
Aims: To determine the clinicopathological features of CNSGCTs diagnosed at our center.
Settings And Design: A retrospective study of all histologically diagnosed CNSGCTs, during 2006-2019.
Histopathological, Demographic, and Clinical Signatures of Medulla Oblongata Germ Cell Tumors: A Case Report With the Review of Literature.
Cureus
January 2024
Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, JPN.
Article Synopsis
- The medulla oblongata is a rare site for germ cell tumors (GCTs) in the central nervous system, with limited data on their characteristics and outcomes.
- A case study of a 24-year-old woman with vertigo and swallowing issues revealed a germinoma, which was surgically removed, followed by chemotherapy and irradiation, showing no recurrence after 4 months.
- The literature suggests that GCTs in the medulla oblongata have similar prognosis to those in typical locations, with unique trends including higher age of occurrence, a female majority, and the significant risks associated with cardiac and respiratory functions.
Epidemiological Characteristics and Prognosis Model of Pineal Region Tumors: A Retrospective Analysis Based on the SEER Database.
World Neurosurg
April 2024
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China; Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China. Electronic address:
Article Synopsis
Bilateral uveitis, retinal periphlebitis, and optic neuritis associated with non-pineal central nervous system germinoma.
Retin Cases Brief Rep
December 2023
Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA.
Article Synopsis
- - A 32-year-old male experienced severe visual issues, leading to the diagnosis of bilateral uveitis, retinal periphlebitis, and optic neuritis caused by a non-pineal central nervous system (CNS) germinoma.
- - Upon examination, he showed several eye problems, including decreased visual acuity, optic disc edema, and abnormal imaging findings, which led to further investigation and a brain biopsy confirming the germinoma.
- - Treatment with chemotherapy for the germinoma resulted in significant improvement of his ocular symptoms, highlighting the connection between CNS germinomas and eye conditions like optic neuritis and uveitis.