1 results match your criteria: "GermanyCrescNet GmbHUniversity of Leipzig[Affiliation]"
Clinical evidence-based cutoff limits for GH stimulation tests in children with a backup of results with reference to mass spectrometry.
Eur J Endocrinol
September 2014
Centre for Paediatric Research Leipzig (CPL)Hospital for Children and Adolescents, University of Leipzig, Leipzig, GermanyInstitute for Laboratory MedicineClinical Chemistry and Molecular Diagnostics, University of Leipzig, Paul-List-Straße 13-15, 04103 Leipzig, GermanyCrescNet GmbHUniversity of Leipzig, Leipzig, GermanyPhysikalisch-Technische Bundesanstalt (PTB)Braunschweig, Germany
Context: Cutoff limits of GH stimulation tests to diagnose GH deficiency (GHD) in children and adolescents are not sufficiently validated by clinical studies due to discrepancies in the performance of GH immunoassays and lack of available study populations.
Objective: We aimed to establish new cutoff limits for GH stimulation tests based on clinical evidence and compared these immunoassay-based values with an antibody-independent mass spectrometric method.
Design And Setting: In a retrospective study, GH cutoff limits for eight different immunoassays and isotope dilution mass spectrometry (ID-MS) were calculated from hGH peak concentrations of short-statured children with and without GHD.