1 results match your criteria: "Germany. timm.westhoff@marienhospital-herne.de.[Affiliation]"
Urinary biomarkers for the differentiation of prerenal and intrinsic pediatric acute kidney injury.
Pediatr Nephrol
December 2016
Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University of Bochum, Bochum, Germany.
Article Synopsis
- Urinary calprotectin and NGAL are emerging biomarkers for distinguishing between prerenal and intrinsic acute kidney injury (AKI) in kids, with this study focusing on their effectiveness compared to KIM-1.
- The analysis included 139 pediatric subjects and found that calprotectin levels were significantly higher in intrinsic AKI patients (22 times more) than in prerenal AKI patients, while NGAL levels were also elevated (9 times more).
- Overall, calprotectin demonstrated superior diagnostic accuracy (AUC of 0.90) compared to NGAL (0.73) and KIM-1 (0.50), making it a better marker for differentiating types of AKI in the pediatric population