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Protein corona formation and its influence on biomimetic magnetite nanoparticles.

J Mater Chem B

June 2020

Freie Universität Berlin, Institute of Pharmacy, Königin-Luise-Str. 2-4, 14195 Berlin, Germany and University of British Columbia, Faculty of Pharmaceutical Sciences, 2405 Wesbrook Mall, Vancouver, BC, Canada.

Biomimetic magnetite nanoparticles (BMNPs) synthesized in the presence of MamC, a magnetosome-associated protein from Magnetoccus marinus MC-1, have gained interest for biomedical applications because of their unique magnetic properties. However, their behavior in biological systems, like their interaction with proteins, still has to be evaluated prior to their use in clinics. In this study, doxorubicin (DOXO) as a model drug was adsorbed onto BMNPs to form nanoassemblies.

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