1 results match your criteria: "Germany and Technical University Munich WZW Chair of Bioinformatics[Affiliation]"
Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations.
Bioinformatics
November 2014
German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Muenchen, 85764 Neuherberg, Germany and Technical University Munich WZW Chair of Bioinformatics, 80333 Munich, Germany German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Muenchen, 85764 Neuherberg, Germany and Technical University Munich WZW Chair of Bioinformatics, 80333 Munich, Germany.
Motivation: Diseases and adverse drug reactions are frequently caused by disruptions in gene functionality. Gaining insight into the global system properties governing the relationships between genotype and phenotype is thus crucial to understand and interfere with perturbations in complex organisms such as diseases states.
Results: We present a systematic analysis of phenotypic information of 5047 perturbations of single genes in mice, 4766 human diseases and 1666 drugs that examines the relationships between different gene properties and the phenotypic impact at the organ system level in mammalian organisms.