1 results match your criteria: "Germany German Center for Infectious Diseases DZIF[Affiliation]"
Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice.
Infect Immun
January 2015
Department of Experimental Pneumology, Hannover Medical School, Hannover, Germany German Center for Infectious Diseases DZIF, Hannover, Germany
Article Synopsis
- Mincle, a pattern recognition receptor, is important for sensing mycobacterial infections through the recognition of a specific cell wall component of mycobacteria called trehalose-6',6-dimycolate (TDM).
- Mincle-knockout mice infected with Mycobacterium bovis BCG showed greater bacterial growth in their spleens and livers compared to wild-type mice, as well as reduced granuloma formation and diminished Th1 cytokine production.
- The study indicates that Mincle-expressing classical dendritic cells play a key role in controlling mycobacterial infections, suggesting their importance over Mincle-expressing macrophages in the immune response following a systemic bacterial challenge.