1,044 results match your criteria: "Germany D-66421; and Wisconsin National Primate Research Center (J.E.L.)[Affiliation]"
J Clin Med
December 2024
Department of Pediatric Cardiology, Saarland University Medical Center, D-66421 Homburg, Germany.
Systemic-to-pulmonary collaterals (SPCs) are common in congenital heart disease (CHD). Particularly in single ventricle anatomy and Fontan circulation, SPC can both complicate the postoperative course and lead to clinical deterioration in the long term. The treatment of SPC is controversial.
View Article and Find Full Text PDFEur Heart J Case Rep
January 2025
Department of Pediatric Cardiology, Saarland University Medical Center, Kirrberger Str., Building 9, D-66421 Homburg/Saar, Germany.
Mol Ther
December 2024
Center of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, D-66421, Homburg/Saar, Germany. Electronic address:
JACS Au
December 2024
Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarbrücken D-66123, Germany.
is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires lengthy culturing for species identification from swabs or an invasive biopsy. To date, no fast, pathogen-specific diagnostic tools for infections are available.
View Article and Find Full Text PDFArch Virol
November 2024
Center of Human and Molecular Biology (ZHMB), Institute of Human Genetics, Saarland University (USAAR), Kirrbergerstraße, Haus 60, Building 60, D-66421, Homburg/Saar, Germany.
Epstein-Barr virus nuclear antigen 1 (EBNA1) contains two arginine-glycine (RG) repeats that contain symmetric/asymmetric dimethylarginine (SDMA/ADMA) and monomethylarginine (MMA) residues. We generated mouse monoclonal antibodies directed against a monomethylated GRGRGG-containing repeat located between amino acids 328 and 377 of EBNA1. In addition to detecting MMA-modified EBNA1, we also had the goal of identifying cellular proteins that bind to MMA-modified EBNA1 in EBV-positive Raji cells.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Center of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421, Homburg/Saar, Germany.
Osteoarthritis is a progressive, irreversible debilitating whole joint disease that affects millions of people worldwide. Despite the availability of various options (non-pharmacological and pharmacological treatments and therapy, orthobiologics, and surgical interventions), none of them can definitively cure osteoarthritis in patients. Strategies based on the controlled release of therapeutic compounds via biocompatible materials may provide powerful tools to enhance the spatiotemporal delivery, expression, and activities of the candidate agents as a means to durably manage the pathological progression of osteoarthritis in the affected joints upon convenient intra-articular (injectable) delivery while reducing their clearance, dissemination, or side effects.
View Article and Find Full Text PDFJ Colloid Interface Sci
February 2025
Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany. Electronic address:
Evaporation of blood droplets and diluted blood samples is a topic of intensive research, as it is considered a potential low-cost diagnostic tool. So far, samples with a volume fraction down to a few percent of red blood cells have been studied, and these were reportedly dominated by a "coffee-ring" deposit. In this study, samples with lower volume fractions were used to investigate the growth of the evaporative deposit from sessile droplets in more detail.
View Article and Find Full Text PDFCancer Imaging
October 2024
Departments of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Inorg Chem
October 2024
Department of Nuclear Medicine, Saarland University-Medical Center, Kirrbergerstrasse, D-66421 Homburg, Germany.
In this work, we describe the complex formation and radiochemistry of the cyclen-based chelator DOTI-Me bearing four methylimidazole arms. Radiolabeling properties were evaluated for Mn, Cu, Ga, In, Tb, and Lu, and DOTI-Me showed distinct differences to the structurally related HDOTA. While radiochemical conversions (RCCs) for Mn and In were comparable to those of HDOTA, DOTI-Me was not suited for Ga.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2024
Division of Analytics, Research Triangle Institute International, Atlanta, GA 30329.
Med Int (Lond)
August 2024
Institute of Anatomy and Cell Biology, Faculty of Medicine, Saarland University, D-66421 Homburg/Saar, Germany.
BMC Nephrol
July 2024
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, D-48149, Münster, Germany.
Background: Rhabdomyolysis describes a syndrome characterized by muscle necrosis and the subsequent release of creatine kinase and myoglobin into the circulation. Myoglobin elimination with extracorporeal hemoadsorption has been shown to effectively remove myoglobin from the circulation. Our aim was to provide best practice consensus statements developed by the Hemoadsorption in Rhabdomyolysis Task Force (HRTF) regarding the use of hemadsorption for myoglobin elimination.
View Article and Find Full Text PDFExp Ther Med
September 2024
Institute of Anatomy and Cell Biology, Saarland University, Faculty of Medicine, D-66421 Homburg, Germany.
Eur J Nucl Med Mol Imaging
November 2024
Department of Nuclear Medicine, Saarland University - Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Aim: Rechallenge of [Lu]Lu-PSMA-617 radioligand therapy (RLT) was proposed for patients who initially responded to PSMA-RLT experiencing partial remission, but relapsed into progression after a certain period of remission. However, only limited data is available regarding this approach. In this study, we analyzed the efficacy and safety profile of one or more series of [Lu]Lu-PSMA-617 RLT rechallenge in patients from a prospective registry (REALITY Study, NCT04833517) after they initially benefited from PSMA-RLT.
View Article and Find Full Text PDFEur Heart J
August 2024
Department of Cardiology and Angiology, Medical Center, University of Freiburg, Bad Krozingen, Germany.
Biomedicines
May 2024
Department of Gynecology, Obstetrics and Reproductive Medicine, University Medical School of Saarland, D-66421 Homburg, Germany.
Background: Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover markers with oncologic outcomes.
Methods: We included 80 women with BC, who were operated on at the Department of Gynecology, Obstetrics and Reproductive Medicine, Homburg/Saar, Germany.
Cancers (Basel)
May 2024
Department of Diagnostic Radiology, King Hussein Cancer Center (KHCC), Amman 11941, Jordan.
The objective of this retrospective study is to assess the effectiveness and safety of two beta-emitting prostate-specific membrane antigen (PSMA) radioligands, [Lu]Lu and [161Tb]Tb, in heavily treated patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 148 cycles of beta-emitting PSMA radioligand therapy were given to 53 patients at a specialized cancer care center in Amman, Jordan. This treatment was offered following the exhaustion of all prior treatment modalities.
View Article and Find Full Text PDFThromb Res
July 2024
Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Drienerlolaan 5, 7522NB Enschede, the Netherlands.
Med Int (Lond)
April 2024
Department of Neurosurgery, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
Osteoarthritis Cartilage
September 2024
Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg/Saar D-66421, Germany. Electronic address:
Objective: Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females.
View Article and Find Full Text PDFBone Rep
June 2024
Institute of Human Genetics, Saarland University, D-66421 Homburg, Germany.
Osteolyses are common findings in elderly patients and most frequently represent malignant or locally aggressive bone tumors, infection, inflammatory and endocrine disorders, histiocytoses, and rare diseases such as Gorham-Stout syndrome. We here report on a novel entity of massive multifocal osteolyses in both shoulders, the right hip and left knee joint and the dens of an 83-year-old patient not relatable to any previously known etiopathology of bone disorders. The soft tissue mass is of myxoid stroma with an unspecific granulomatous inflammatory process, aggressively destroying extensive cortical and cancellous bone segments and encroaching on articulating bones in diarthrodial large joints.
View Article and Find Full Text PDFBioorg Med Chem
May 2024
Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Corrensstr. 48, 48149 Münster, Germany. Electronic address:
The human phosphatidylinositol 4-phosphate 5-kinase type I α (hPIP5K1α) plays a key role in the development of prostate cancer. In this work, seventeen derivatives of the natural diterpene totarol were prepared by copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction of the correspondingO-propargylated totarol with aryl or alkyl azides and screened for their inhibitory activities toward hPIP5K1α. Five compounds, 3a, 3e, 3f, 3i, and 3r, strongly inhibited the enzyme activity with IC values of 1.
View Article and Find Full Text PDFArch Gynecol Obstet
June 2024
Department for Gynaecology, Saarland University Hospital, Obstetrics and Reproductive Medicine, Kirrberger Straße 100, Building 9, D-66421, Homburg, Germany.
Introduction: For years, generations of medical students have complained that practice-oriented learning is neglected in medical studies. Further training assistants also complain about limited opportunities to learn subject-specific practical activities.
Material And Techniques: We are presenting a pilot project at the University Women's Hospital in Homburg, in which medical students complete an endoscopic hands-on course as part of the block internship gynaecology and obstetrics.
Cancer Imaging
February 2024
Department of Nuclear Medicine, Saarland University- Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Background: The state-of-the-art method for imaging men with biochemical recurrence of prostate cancer (BCR) is prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) with tracers containing short-lived radionuclides, e.g., gallium-68 (Ga; half-life: ∼67.
View Article and Find Full Text PDFCancers (Basel)
December 2023
Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, D-66421 Homburg, Germany.
Primary chemoradiotherapy (CRT) is an established treatment option for locally advanced head and neck squamous cell carcinomas (HNSCC) usually combining intensity modified radiotherapy with concurrent platinum-based chemotherapy. Though the majority of patients can be cured with this regimen, treatment response is highly heterogeneous and can hardly be predicted. SEC62 represents a metastasis stimulating oncogene that is frequently overexpressed in various cancer entities and is associated with poor outcome.
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