1,044 results match your criteria: "Germany D-66421; and Wisconsin National Primate Research Center (J.E.L.)[Affiliation]"

Systemic-to-pulmonary collaterals (SPCs) are common in congenital heart disease (CHD). Particularly in single ventricle anatomy and Fontan circulation, SPC can both complicate the postoperative course and lead to clinical deterioration in the long term. The treatment of SPC is controversial.

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  • Despite the lack of a cure for osteoarthritis, researchers aimed to address mitochondrial dysfunction by developing a new treatment that uses mitochondria to deliver gene therapy via recombinant adeno-associated viral (rAAV) vectors.
  • The study demonstrated that this mitochondria/rAAV system could successfully increase the expression of insulin-like growth factor I (IGF-I) in human osteoarthritic chondrocytes, showing up to an 8.4-fold increase compared to controls.
  • The strategy not only improved cell proliferation and survival but also boosted the production of the extracellular matrix and enhanced mitochondrial function, indicating its potential as a promising treatment for osteoarthritis.
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High-Affinity Lectin Ligands Enable the Detection of Pathogenic Biofilms: Implications for Diagnostics and Therapy.

JACS Au

December 2024

Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarbrücken D-66123, Germany.

is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires lengthy culturing for species identification from swabs or an invasive biopsy. To date, no fast, pathogen-specific diagnostic tools for infections are available.

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Epstein-Barr virus nuclear antigen 1 (EBNA1) contains two arginine-glycine (RG) repeats that contain symmetric/asymmetric dimethylarginine (SDMA/ADMA) and monomethylarginine (MMA) residues. We generated mouse monoclonal antibodies directed against a monomethylated GRGRGG-containing repeat located between amino acids 328 and 377 of EBNA1. In addition to detecting MMA-modified EBNA1, we also had the goal of identifying cellular proteins that bind to MMA-modified EBNA1 in EBV-positive Raji cells.

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Therapeutic Controlled Release Strategies for Human Osteoarthritis.

Adv Healthc Mater

January 2025

Center of Experimental Orthopaedics, Saarland University and Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421, Homburg/Saar, Germany.

Osteoarthritis is a progressive, irreversible debilitating whole joint disease that affects millions of people worldwide. Despite the availability of various options (non-pharmacological and pharmacological treatments and therapy, orthobiologics, and surgical interventions), none of them can definitively cure osteoarthritis in patients. Strategies based on the controlled release of therapeutic compounds via biocompatible materials may provide powerful tools to enhance the spatiotemporal delivery, expression, and activities of the candidate agents as a means to durably manage the pathological progression of osteoarthritis in the affected joints upon convenient intra-articular (injectable) delivery while reducing their clearance, dissemination, or side effects.

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Deposit of Red Blood Cells at low concentrations in evaporating droplets is dominated by a central edge growth.

J Colloid Interface Sci

February 2025

Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany. Electronic address:

Evaporation of blood droplets and diluted blood samples is a topic of intensive research, as it is considered a potential low-cost diagnostic tool. So far, samples with a volume fraction down to a few percent of red blood cells have been studied, and these were reportedly dominated by a "coffee-ring" deposit. In this study, samples with lower volume fractions were used to investigate the growth of the evaporative deposit from sessile droplets in more detail.

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  • A study analyzed 38 men with biochemical recurrence (BCR) of prostate cancer, using a specialized PET/CT imaging technique to track prostate-specific membrane antigen (PSMA) with zirconium-89 radiotracers after prior negative scans.* -
  • The results showed that the new imaging method detected a total of 57 lesions, including local recurrences and metastases, in 78% of patients, with significant improvement in tumor visibility over time.* -
  • The study concludes that zirconium-89 PSMA PET/CT is effective for identifying early BCR and suggests that the imaging technique outperforms conventional methods, with no noted side effects and a decrease in prostate-specific antigen levels in treated patients.*
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In this work, we describe the complex formation and radiochemistry of the cyclen-based chelator DOTI-Me bearing four methylimidazole arms. Radiolabeling properties were evaluated for Mn, Cu, Ga, In, Tb, and Lu, and DOTI-Me showed distinct differences to the structurally related HDOTA. While radiochemical conversions (RCCs) for Mn and In were comparable to those of HDOTA, DOTI-Me was not suited for Ga.

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TRPC6 is ubiquitously present in lymphatic tissues: A study using samples from body donors.

Med Int (Lond)

August 2024

Institute of Anatomy and Cell Biology, Faculty of Medicine, Saarland University, D-66421 Homburg/Saar, Germany.

Article Synopsis
  • TRPC6 is a channel in our body that helps control the movement of certain ions and is linked to various diseases.
  • The study looked for TRPC6 in different types of human lymphatic tissues using a special staining technique to see if it was present.
  • Results showed that TRPC6 was found in many parts of the lymphatic system, which might help explain how the immune response works.
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Background: Rhabdomyolysis describes a syndrome characterized by muscle necrosis and the subsequent release of creatine kinase and myoglobin into the circulation. Myoglobin elimination with extracorporeal hemoadsorption has been shown to effectively remove myoglobin from the circulation. Our aim was to provide best practice consensus statements developed by the Hemoadsorption in Rhabdomyolysis Task Force (HRTF) regarding the use of hemadsorption for myoglobin elimination.

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Distribution of TRPC5 in the human lung: A study in body donors.

Exp Ther Med

September 2024

Institute of Anatomy and Cell Biology, Saarland University, Faculty of Medicine, D-66421 Homburg, Germany.

Article Synopsis
  • TRPC5 is a non-selective ion channel that plays a role in downstream signaling and is linked to diseases like asthma and pulmonary hypertension caused by issues with ion balance in cells.
  • The study aimed to clarify TRPC5's protein expression in human lung tissues, revealing its presence in multiple lung structures including pleura, pulmonary arteries, and alveolar cells.
  • Findings suggest TRPC5 may be significant for lung function and disease, indicating its potential as a new drug target for treating lung conditions, though additional research is needed.
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Aim: Rechallenge of [Lu]Lu-PSMA-617 radioligand therapy (RLT) was proposed for patients who initially responded to PSMA-RLT experiencing partial remission, but relapsed into progression after a certain period of remission. However, only limited data is available regarding this approach. In this study, we analyzed the efficacy and safety profile of one or more series of [Lu]Lu-PSMA-617 RLT rechallenge in patients from a prospective registry (REALITY Study, NCT04833517) after they initially benefited from PSMA-RLT.

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Background: Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover markers with oncologic outcomes.

Methods: We included 80 women with BC, who were operated on at the Department of Gynecology, Obstetrics and Reproductive Medicine, Homburg/Saar, Germany.

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The objective of this retrospective study is to assess the effectiveness and safety of two beta-emitting prostate-specific membrane antigen (PSMA) radioligands, [Lu]Lu and [161Tb]Tb, in heavily treated patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 148 cycles of beta-emitting PSMA radioligand therapy were given to 53 patients at a specialized cancer care center in Amman, Jordan. This treatment was offered following the exhaustion of all prior treatment modalities.

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  • Hughes-Stovin syndrome (HSS) is a rare condition characterized by systemic vasculitis leading to both venous and arterial thrombosis, making it hard to differentiate from pulmonary embolism (PE) early on.
  • This study compared 40 HSS patients to 50 PE patients, analyzing demographics, clinical findings, and results from computed tomography pulmonary angiography (CTPA).
  • Results revealed that HSS patients were significantly younger and did not have co-morbidities like many PE patients; HSS showed unique vascular changes, including more frequent parenchymal hemorrhage and distinct pulmonary artery aneurysms.*
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  • The study compares the peak insertion torques of three types of screws used for cervical spine fixation: lateral mass screws (LMS), pedicle screws, and the new Attallah screw.
  • Results indicate that while the Attallah screw has comparable torque to pedicle screws at certain cervical levels, it generally shows lower strength at C5 and C6.
  • Overall, the findings suggest that the Attallah screw is a viable option for posterior cervical fixation, but pedicle screws are still considered superior in strength, especially between C5 and C6.
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Objective: Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females.

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Osteolyses are common findings in elderly patients and most frequently represent malignant or locally aggressive bone tumors, infection, inflammatory and endocrine disorders, histiocytoses, and rare diseases such as Gorham-Stout syndrome. We here report on a novel entity of massive multifocal osteolyses in both shoulders, the right hip and left knee joint and the dens of an 83-year-old patient not relatable to any previously known etiopathology of bone disorders. The soft tissue mass is of myxoid stroma with an unspecific granulomatous inflammatory process, aggressively destroying extensive cortical and cancellous bone segments and encroaching on articulating bones in diarthrodial large joints.

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1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors.

Bioorg Med Chem

May 2024

Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Corrensstr. 48, 48149 Münster, Germany. Electronic address:

The human phosphatidylinositol 4-phosphate 5-kinase type I α (hPIP5K1α) plays a key role in the development of prostate cancer. In this work, seventeen derivatives of the natural diterpene totarol were prepared by copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction of the correspondingO-propargylated totarol with aryl or alkyl azides and screened for their inhibitory activities toward hPIP5K1α. Five compounds, 3a, 3e, 3f, 3i, and 3r, strongly inhibited the enzyme activity with IC values of 1.

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Introduction: For years, generations of medical students have complained that practice-oriented learning is neglected in medical studies. Further training assistants also complain about limited opportunities to learn subject-specific practical activities.

Material And Techniques: We are presenting a pilot project at the University Women's Hospital in Homburg, in which medical students complete an endoscopic hands-on course as part of the block internship gynaecology and obstetrics.

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Background: The state-of-the-art method for imaging men with biochemical recurrence of prostate cancer (BCR) is prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) with tracers containing short-lived radionuclides, e.g., gallium-68 (Ga; half-life: ∼67.

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Primary chemoradiotherapy (CRT) is an established treatment option for locally advanced head and neck squamous cell carcinomas (HNSCC) usually combining intensity modified radiotherapy with concurrent platinum-based chemotherapy. Though the majority of patients can be cured with this regimen, treatment response is highly heterogeneous and can hardly be predicted. SEC62 represents a metastasis stimulating oncogene that is frequently overexpressed in various cancer entities and is associated with poor outcome.

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