1 results match your criteria: "Germany Cancer Research Centre (DKFZ)[Affiliation]"
The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease.
Hepatobiliary Surg Nutr
April 2015
1 Centre of Alcohol Research, University of Heidelberg, Heidelberg, Germany ; 2 Department of Medicine (Gastroenterology & Hepatology), Salem Medical Centre, Heidelberg, Germany ; 3 Division of Toxicology and Cancer Risk Factors, Germany Cancer Research Centre (DKFZ), Heidelberg, Germany.
Background: Nonalcoholic fatty liver disease (NAFLD), in particular its more aggressive form nonalcoholic steatohepatitis (NASH) is increasingly observed as a cause of end stage liver disease and hepatocellular carcinoma (HCC). Reactive oxygen species (ROS) are an important factor in the pathogenesis of HCC. ROS can react with polyunsaturated fatty acids derived from membrane phospholipids resulting in the production of reactive aldehydes as lipid oxidation (LPO) byproducts, such as 4-hydroxynonenal (4 HNE).
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