1 results match your criteria: "Germany 7 German Centre for Neurodegenerative Diseases (DZNE)[Affiliation]"
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.
Brain
February 2016
1 Department of Psychiatry and Psychotherapy, University Medicine Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany 2 Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany 3 Cluster of Excellence 'Nanoscale Microscopy and Molecular Physiology of the Brain' (CNMPB), Göttingen, Germany 7 German Centre for Neurodegenerative Diseases (DZNE), Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany
Extracellular α-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular α-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal α-synuclein is present in the central nervous system in vivo.
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