The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study.

Importance: Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field.

Objective: To develop an evidence-informed, consensus-guided, adaptable digital health competencies framework for the design and development of digital health curricula in medical institutions globally.

Evidence Review: A core group was assembled to oversee the development of the Digital Health Competencies in Medical Education (DECODE) framework.

Nocturia as a clinical marker of loss of function and resilience or risk factor for frailty in older adults? Results of the Berlin Aging Study II.

The current study examined cross-sectional and longitudinal associations between nocturia and frailty in a cohort of men and women aged 60 years and older, as evidence on this topic was lacking. We analyzed baseline and follow-up data (n = 1671) from the Berlin Aging Study II (BASE-II), a prospective longitudinal cohort study focusing on the factors associated with "healthy" vs. "unhealthy" aging.

Which Training Intensity Distribution Intervention will Produce the Greatest Improvements in Maximal Oxygen Uptake and Time-Trial Performance in Endurance Athletes? A Systematic Review and Network Meta-analysis of Individual Participant Data.

Background: Endurance athletes tend to accumulate large training volumes, the majority of which are performed at a low intensity and a smaller portion at moderate and high intensity. However, different training intensity distributions (TID) are employed to maximize physiological and performance adaptations.

Objective: The objective of this study was to conduct a systematic review and network meta-analysis of individual participant data to compare the effect of different TID models on maximal oxygen uptake (VO) and time-trial (TT) performance in endurance-trained athletes.

In silico analysis of non-conventional gene targets for genetic interventions to enhance fatty acid production: a review.

Since the 1990s, fatty acids (FA) have drawn significant industrial attention due to their diverse applications creating a demand for biological systems capable of producing high FA titers. While various strategies have been explored to achieve this, many of the conventional approaches rely on extensive genetic manipulations, which often result in strain instability, thus limiting its potential to yield better FA titers. Moreover, stresses such as pH, osmotic, and oxidative imbalances generated during FA production aggravate these challenges, further limiting FA titers.

Metal pollution reconstruction in São Paulo City (Southeast Brazil) over the twentieth century by paleolimnological approach.

In this study, we evaluated the pollution history by metals over the twentieth century in an urban reservoir (Garças Reservoir, Metropolitan Region of São Paulo, Southeast Brazil) by the paleolimnological approach. The concentrations of eight metals (Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn) were determined in a Pb-dated sediment core (~ 100 years of information). Metal's enrichment and pollution degree were assessed using the Consensus-Based Sediment Quality Guidelines (CBSQG), enrichment factor (EF), Geoaccumulation Index (I), and Potential Ecological Risk Index (RI).

Mobile Applications for Longitudinal Data Collection: Web-based Survey Study of Former Intensive Care Patients.

Purpose: Mobile health plays an important role in providing individualized information about the health status of patients. Limited information exists on intensive care unit (ICU) patients with the risk of suffering from the post-intensive care syndrome (PICS), summarizing long-term physical, mental and cognitive impairment. This web-based survey study aims to identify specific needs of former ICU patients for utilizing a newly developed, so called Post-Intensive Care Outcome Surveillance (PICOS) app to collect relevant PICS-related parameters.

Comparison of surgical approaches and outcome for symptomatic pineal cysts: microscopic/endoscopic fenestration vs. stereotactic catheter implantation.

Purpose: Treatment strategies for space-occupying/symptomatic pineal cysts (PC) are still up for debate. In this study we present PC management, outcome data and risk factors for recurrence after surgery, focusing on microscopic/endoscopic procedures vs. stereotactic catheter implantation as alternative treatment concept to permanently drain PC into ventricles/cisterns.

Comparison of continuous glucose monitoring with self-monitoring of blood glucose in type 1 diabetes in the changing atmospheric pressures in aviation: a hypobaric flight simulation.

Aim/hypothesis: Pilots with type 1 diabetes are required to perform capillary glucose monitoring regularly during flights. Continuous glucose monitoring (CGM) may be an effective and more practical alternative. This study aimed to assess the accuracy of CGM systems against self-monitoring of blood glucose (SMBG) during a hypobaric flight simulation.

Tat_BioV: tattoo ink exposure and biokinetics of selected tracers in a short-term clinical study of 24 subjects.

About one-fifth of people in industrialised countries are tattooed, potentially putting them at risk of exposure to possible carcinogenic or otherwise harmful substances. This study aims to determine the exposure to soluble tattoo ink ingredients and their excretion within 24 h after tattooing. In this clinical study, 24 subjects were tattooed with black or red tattoo ink to which the 3 tracer substances, potassium iodide, 4-aminobenzoic acid (PABA) and 2-phenoxyethanol (PEtOH), had been added to mimic known substances found in tattoo inks.

Biomarker microRNA-371a-3p - expression in malignancies other than germ-cell tumours.

Purpose: microRNA-371a-3p (M371) is considered a highly sensitive and specific serum biomarker of testicular germ cell tumours (GCTs). However, little is known about the expression of M371 in nontesticular malignancies (NTMs), so far. As knowledge about the expression of the marker in other malignancies is a prerequisite for the clinical application of the test we aimed to explore the M371 expression in other cancers.

Microbiological findings in a cohort of patients with coronavirus disease 2019 and venovenous extracorporeal membrane oxygenation.

Background: Venovenous extracorporeal membrane oxygenation (VV ECMO) is an established support option for patients with very severe respiratory failure and played an important role during the coronavirus disease 2019 (COVID-19) pandemic. Bacteria and fungi can lead to severe infectious complications in critically ill patients. The aim of this study was to describe the microbiological spectrum of bacteria and fungi detected in patients with COVID-19-associated respiratory failure supported with VV ECMO in our center.

Role of membrane porosity in passive sampling of aquatic contaminants for stable isotope analysis: enhancement of analyte accumulation rates and selectivity.

Compound-specific isotope analysis (CSIA) is a potent method for illustrating the in situ degradation of aquatic contaminants. However, its application to surface and groundwater is hindered by low contaminant concentrations, typically in the nanogram-per-litre range, requiring the processing of large water volumes. Polar organic chemical integrative samplers (POCIS) have shown promising results when combined with CSIA, yet their extended deployment time to accumulate sufficient analyte mass remains a major limitation.

How I diagnose and treat patients in the pre-fibrotic phase of primary myelofibrosis (pre-PMF) - practical approaches of a German expert panel discussion in 2024.

The prefibrotic phase of primary myelofibrosis (pre-PMF) represents a distinct subentity within the spectrum of myeloproliferative neoplasms (MPNs), recognized by the World Health Organization (WHO) and the International Consensus Classification (ICC). Pre-PMF is characterized by unique morphological, clinical, and molecular features, distinguishing it from essential thrombocythemia (ET) and overt myelofibrosis (overt-PMF). The diagnostic process for pre-PMF relies on bone marrow histology, identification of molecular mutations and exclusion of other myeloid neoplasms.

Effects of acute stress on cue reactivity and implicit cognitions in online compulsive buying-shopping disorder.

Background And Aims: There is a lack of research on the impact of acute stress on the interaction of affective and cognitive processes in online compulsive buying-shopping disorder (CBSD). Therefore, this project addressed stress response, cue reactivity, attentional bias, and implicit associations in individuals with online CBSD.

Methods: Women with CBSD (n = 63) and women with non-problematic online buying-shopping (n = 64) were randomly assigned to the Trier Social Stress Test or a non-stress condition.

High-Dielectric 2D Bismuth Oxides with Large Bandgaps: The Role of 6s Lone Pair Hybridization.

Large-bandgap and high-dielectric 2D dielectrics are crucial for transistor performance because they maximize gate-to-channel capacitive coupling, yet such high-quality materials remain scarce. This study employed first-principles calculations to predict 18 distinct 2D bismuth oxides (BiOs). It is demonstrated that the 6s lone pairs in 2D BiOs form benign positive feedback between the bandgap and dielectric constant.

Effect of Synchronized Radiofrequency and High-Intensity Facial Electrical Stimulation (HIFES) of the Upper Face.

Background: Effects of upper facial aging can present as static forehead and periorbital rhytids as well as soft tissue volume loss. The latter can prompt in conjunct with bony changes of the calvaria eyebrow and eyelid ptosis. Injection-based treatments can yield positive outcomes but are not free of procedural risks.

The levels of adropin and its therapeutic potential in diabetes.

Adropin, a peptide hormone encoded by the ENHO gene is expressed in various tissues including the brain. Accumulating evidence from in vivo and in vitro studies highlights adropin's pivotal role in modulating carbohydrate and lipid metabolism. Notably, circulating adropin levels are lower in overweight and obese humans and experimental interventions involving adropin overexpression or synthetic administration demonstrate promising outcomes in mitigating obesity-related metabolic abnormalities and preventing weight gain.

Multimetallic Half-Sandwich Complexes of the Rare-Earth Metals.

Multimetallic half-sandwich complexes of the paramagnetic lanthanides gadolinium, terbium, dysprosium, holmium, and erbium as well as of diamagnetic yttrium are readily accessible via AlMe/halogenido exchange reactions of Cp*Ln(AlMe) with the mild halogenido transfer reagents MeSiI and MeGeX (Cp* = CMe; X = Br, Cl). Depending on the rare-earth-metal center and halogenido ion size, complexes with distinct structural motifs and nuclearities are obtained, including dimeric compounds [Cp*Ln(AlMe)(μ-Cl)] for the smaller metal centers Ln = Ho, Er, iodido-bridged tetranuclear rings [Cp*Ln(μ-I)] (Ln = Y, Tb, Dy, Ho, Er), and a heterobimetallic tetramethylaluminato-bridged gadolinium cluster [Cp*GdI(AlMe)]. The tetranuclear dysprosium complex [Cp*Dy(μ-I)] shows single-molecule magnet (SMM) behavior in zero applied field with an effective energy barrier of 164(10) cm.

A versatile two-light mode triggered system for highly localized sequential release of reactive oxygen species and conjugated drugs from mesoporous organosilica particles.

The increasing prevalence of antimicrobial resistance and adverse effects of systemic treatments calls for urgent reevaluation of current methods that rely on excessive, uncontrolled drug administration. In recent years triggerable systems have emerged as promising alternatives, enabling time-controlled and localized drug release, which are only activated if necessary. Light is an obvious candidate as an external trigger, since it allows for localized activation, is non-invasive and its wavelength and intensity can be tailored to fit the demands of the drug release system.

Unveiling Molecular Dynamics of MeCp2, CDKL5 and BDNF in the Hippocampus of Individuals With Intractable Mesial Temporal Lobe Epilepsy.

Mutations occurring in the MeCp2, CDKL5 and BDNF genes have been linked to epileptogenesis in various epilepsy syndromes. This study employed bioinformatics analysis of transcriptomic data to examine the interrelationship among these genes in both epileptic and healthy individuals. Moreover, we assessed the expression of MeCp2, CDKL5 and BDNF at both mRNA and protein levels in human hippocampal tissues obtained from 22 patients undergoing epilepsy surgery for mesial temporal lobe epilepsy (MTLE) as well as from 25 autopsied specimens.

Exploring the Adsorption Features of Furan and 1,n-Dioxane as Environmental Toxins on Two-Dimensional RuC Nanosheet: A DFT Study.

The potential of the two-dimensional ruthenium carbide (RuC) nanosheet to detect highly toxic environmental compounds - namely, Furan (Fur) and 1,n-Dioxane (1,n-Diox) - was investigated utilizing the density functional theory (DFT) approach. The adsorption features of the Fur and 1,n-Diox molecules on the RuC nanosheet were evaluated in parallel and vertical configurations. From energetic manifestations, Fur and 1,n-Diox molecules preferred to be adsorbed in the parallel configuration rather than the vertical one on the RuC nanosheet with negative E values of -27.

Silver-Catalyzed Decarboxylative Coupling of Oxamic Acids with Styrenes to Synthesize E-Cinnamamides: A Distinguish Reaction Pathway.

A silver-catalyzed decarboxylative coupling of oxamic acids with styrenes has been developed to produce E-cinnamamides. Oxamic acids act as efficient precursors for carbamoy radicals. Based on the mechanistic experiments and intermediate analysis, the proposed mechanism involves radical addition to styrenes, followed by oxidation and solvent participation, ultimately leading to the formation of cinnamamides which is different from the reported cases.