1,540,529 results match your criteria: "Germany; Max Planck Institute for Biology of Aging[Affiliation]"

Aim: Complete mesocolic excision (CME) is an oncologically driven technique for treating right colon cancer. While laparoscopic CME is technically demanding and has been associated with more complications, the robotic approach might reduce morbidity. The aim of this study was to assess the safety of stepwise implementation of robotic CME.

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Anode free concepts are gaining traction in battery research. To improve cyclability, a better understanding of the deposition processes and morphologies is necessary. Correlative experiments enable a link between a variety of properties obtained, such as chemical, mechanical or electrochemical data.

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The development of versatile strategies for preparing functional carbon materials is essential for advancing a wide range of applications in materials science. Precursor design plays a pivotal role in governing the chemistry and structure of carbon materials for target applications. In this work, we report the synthesis of Meldrum's acid derivatives through Knoevenagel condensation with aromatic heterocycles such as pyrrole, furan, and thiophene, which serve as precursors for carbonaceous materials with tailored chemical and electronic properties.

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Three-dimensional covalent organic frameworks (3D COFs), a class of highly porous crystalline polymers, have exhibited great potentials in many applications. However, the reported topologies of 3D COFs have been limited to high-symmetry crystal systems, which significantly hindered the development of such functional materials. Herein, we demonstrate the first construction of four highly crystalline orthorhombic 3D COFs with an unprecedented fmj topology, based on judiciously choosing rotatable monomers.

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Background: Due to malnutrition and tumor cachexia, body composition (BC) is frequently altered and known to adversely affect short- and long-term results in patients with cholangiocarcinoma (CCA). Here, we explored immune cell populations in the tumor and liver of CCA patients with respect to BC.

Methods: A cohort of 96 patients who underwent surgery for CCA was investigated by multiplexed immunofluorescence (MIF) techniques with computer-based analysis on whole-tissue slide scans to quantify and characterize immune cells in normal liver and tumor regions.

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The right heart catheterization (RHC) remains an important diagnostic tool for a spectrum of cardiovascular disease processes including pulmonary hypertension (PH), shock, valvular heart disease, and unexplained dyspnea. While it gained widespread utilization after its introduction, the role of the RHC has evolved to provide valuable information for the management of advanced therapies in heart failure (HF) and cardiogenic shock (CS) to name a few. In this review, we provide a comprehensive overview on the indications, utilization, complications, interpretation, and calculations associated with RHC.

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Background: The emergence of , which can confer resistance to phenicols and oxazolidinones in spp., poses a growing public health threat.

Methods: 102 -positive enterococci (OPEs) including various species were isolated from feces of 719 healthy volunteers in a Shenzhen community, China.

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The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) at the National Institute of Chemistry (NIC) in Ljubljana represents a significant step forward, as it is the first centre of its kind in Slovenia. The CTGCT is poised to spearhead advances in cancer immunotherapy and personalised therapies for neurological and other rare genetic diseases.

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Biomaterial scaffold engineering presents great potential in promoting axonal regrowth after spinal cord injury (SCI), yet persistent challenges remain, including the surrounding host foreign body reaction and improper host-implant integration. Recent advances in mechanobiology spark interest in optimizing the mechanical properties of biomaterial scaffolds to alleviate the foreign body reaction and facilitate seamless integration. The impact of scaffold stiffness on injured spinal cords has not been thoroughly investigated.

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Comprehensive VR dataset for machine learning: Head- and eye-centred video and positional data.

Data Brief

December 2024

Department of Neurophysics, Philipps University Marburg, Karl-von-Frisch Straße 8a, 35043 Marburg, Hesse, Germany.

We present a comprehensive dataset comprising head- and eye-centred video recordings from human participants performing a search task in a variety of Virtual Reality (VR) environments. Using a VR motion platform, participants navigated these environments freely while their eye movements and positional data were captured and stored in CSV format. The dataset spans six distinct environments, including one specifically for calibrating the motion platform, and provides a cumulative playtime of over 10 h for both head- and eye-centred perspectives.

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Introduction: The societal costs of dementia and cognitive decline are substantial and likely to increase during the next decades due to the increasing number of people in older age groups. The aim of this multicenter cluster-randomized controlled trial was to assess the cost-effectiveness of a multi-domain intervention to prevent cognitive decline in older people who are at risk for dementia.

Methods: We used data from a multi-centric, two-armed, cluster-randomized controlled trial ( trial, ID: DRKS00013555).

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Photoacids undergo an increase in acidity upon electronic excitation, enabling excited-state proton transfer (ESPT) reactions. A multitude of compounds that allow ESPT has been identified and integrated in numerous applications, as is outlined by reviewing the rich history of photoacid research reaching back more than 90 years. In particular, achievements together with ambitions and challenges are highlighted from a combined experimental and theoretical perspective.

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Molecular engineering of supramolecular polymer adhesive with confined water and a single crown ether.

Chem Sci

December 2024

Sino-German Joint Research Lab for Space Biomaterials and Translational Technology, Synergetic Innovation Centre of Biological Optoelectronics and Healthcare Engineering, School of Life Sciences, Northwestern Polytechnical University Xi'an Shaanxi 710072 P. R. China

Here, we report a water-induced supramolecular polymer adhesive formed from confined water and an intrinsically amphiphilic macrocyclic self-assembly in a nanophase-separated structure. The selenium-containing crown ether macrocycle, featuring a strong hydrophilic hydrogen-bond receptor (selenoxide) and a synergistic hydrophobic selenium-substituted crown core, confines water within a segregated, interdigitated architecture. While water molecules typically freeze around 0 °C, the confined water in this supramolecular polymer remains in a liquid-like state down to -80 °C.

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Background: There is a lack of information on the current healthcare systems for children with kidney diseases across Europe. The aim of this study was to explore the different national approaches to the organization and delivery of pediatric nephrology services within Europe.

Methods: In 2020, the European society for Paediatric Nephrology (ESPN) conducted a cross-sectional survey to identify the existing pediatric nephrology healthcare systems in 48 European countries covering a population of more than 200 million children.

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In this study, an advanced nanofiber breast cancer model was developed and systematically characterized including physico-chemical, cell-biological and biophysical parameters. Using electrospinning, the architecture of tumor-associated collagen signatures (TACS5 and TACS6) was mimicked. By employing a rotating cylinder or static plate collector set-up, aligned fibers (TACS5-like structures) and randomly orientated fibers (TACS6-like structures) fibers were produced, respectively.

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Colorectal cancer (CRC) represents a major public health challenge globally, particularly in the Gulf Cooperation Council (GCC) countries, where it is identified as the second most prevalent form of cancer. Despite advancements in management strategies, tailored guidelines specific to the Gulf region are lacking. This paper presents consensus recommendations developed by a panel of experts from the GCC countries to address this gap.

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PEG-PLGA nanoparticles deposited in and .

J Pharm Anal

December 2024

Institute of Infectious Disease and Infection Control, Jena University Hospital, Jena, 07747, Germany.

In our prior research, polymer nanoparticles (NPs) containing tobramycin displayed robust antibacterial efficacy against biofilm-embedded () and (. ) cells, critical pathogens in cystic fibrosis. In the current study, we investigated the deposition of a nanoparticulate carrier composed of poly(d,l-lactic--glycolic acid) (PLGA) and poly(ethylene glycol)--PLGA (PEG-PLGA) that was either covalently bonded with cyanine-5-amine (Cy5) or noncovalently bound with freely embedded cationic rhodamine B (RhB), which served as a drug surrogate.

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Objectives: The continuous integration of artificial intelligence (AI) into clinical settings requires the development of up-to-date and robust guidelines and standard frameworks that consider the evolving challenges of AI implementation in medicine. This review evaluates the quality of these guideline and summarizes ethical frameworks, best practices, and recommendations.

Materials And Methods: The Appraisal of Guidelines, Research, and Evaluation II tool was used to assess the quality of guidelines based on 6 domains: scope and purpose, stakeholder involvement, rigor of development, clarity of presentation, applicability, and editorial independence.

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Background: Since the pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the leading trigger for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Evidence indicates that autoimmunity plays an important pathophysiological role. We aimed to evaluate the effectiveness of IA treatment in post-COVID ME/CFS patients.

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The Altai mountains contain a number of cave and rockshelter sites that have given crucial information about human evolution in Asia. Most of these caves are located in the Gornyi Altai of Siberia, while the southern flank of the range remains much less known. Bukhtarma Cave was a karstic cave located near the former village of Peshchera, on the banks of the Bukhtarma River running through the foothills of the southern (Kazakh) Altai mountains.

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Nematophagous fungi as biological control agents of parasitic nematodes in soils of wildlife parks.

Int J Parasitol Parasites Wildl

April 2025

Institute of Veterinary Medicine, Georg-August-University of Goettingen, Burckhardtweg 2, 37077, Goettingen, Germany.

Infections with soil-transmitted helminths pose a significant threat to wildlife in enclosures, where transmission of these parasitic larvae is easier due to the limited space. Nematophagous fungi offer a promising solution as they can naturally control these nematodes. In this study, three nematophagous fungi (, , ) purchased from the non-profit global biological resource center ATCC were tested for their suitability as biological control agents.

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Titanium dioxide nanoparticles: a promising candidate for wound healing applications.

Burns Trauma

January 2025

Research Group of Immune Cell Communication, Department of Immune Medicine, Universitätsklinikum Regensburg | UKR, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

Effective wound management and treatment are crucial in clinical practice, yet existing strategies often fall short in fully addressing the complexities of skin wound healing. Recent advancements in tissue engineering have introduced innovative approaches, particularly through the use of nanobiomaterials, to enhance the healing process. In this context, titanium dioxide nanoparticles (TiO NPs) have garnered attention due to their excellent biological properties, including antioxidant, anti-inflammatory, and antimicrobial properties.

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