Oxygenation and intestinal perfusion and its association with perturbations of the early life gut microbiota composition of children with congenital heart disease.

Background: Early life gut microbiota is known to shape the immune system and has a crucial role in immune homeostasis. Only little is known about composition and dynamics of the intestinal microbiota in infants with congenital heart disease (CHD) and potential influencing factors.

Methods: We evaluated the intestinal microbial composition of neonates with CHD ( = 13) compared to healthy controls (HC,  = 30).

Harnessing Terbium Radioisotopes for Clinical Advancements: A Systematic Review.

Background this systematic review was conducted to assess the practical application of terbium radioisotopes, utilizing systematic search methodologies to identify relevant studies. Methods the databases of PubMed, Web of Science, and Scopus were systematically scoured, targeting the research on four terbium isotopes:  Tb,  Tb,  Tb, and  Tb. Various combinations of keywords related to terbium and its four radioisotopes were used in the search process.

Stable Operation of Copper-Protected La(FeMnSi)H Regenerators in a Magnetic Cooling Unit.

Magnetic refrigeration leads the current commercialization efforts of ambient caloric cooling technologies, is considered among its peers most promising in terms of anticipated energy efficiency gain, and allows for complete elimination of harmful coolants. By now, functional magnetocaloric components (so-called regenerators) based on Mn-substituted and hydrogenated LaFeSi alloys are commercially available. However, this alloy system exhibits magnetostriction, is susceptible to fracture, oxidation, and does not passivate well, rendering it prone to failure and corrosion, particularly when using water as favorable heat exchange medium.

Impact of the external knee flexion moment on patello-femoral loading derived from loads and kinematics.

Introduction: Anterior knee pain and other patello-femoral (PF) complications frequently limit the success of total knee arthroplasty as the final treatment of end stage osteoarthritis. However, knowledge about the loading conditions at the PF joint remains limited, as no direct measurements are available. We hypothesised that the external knee flexion moment (EFM) is highly predictive of the PF contact forces during activities with substantial flexion of the loaded knee.

Significant handling errors and education gaps regarding the use of the emergency kit among adult patients with Hymenoptera venom allergy.

Aim: In case of systemic anaphylactic reactions after Hymenoptera stings, patients should be provided with an adrenaline autoinjector (AAI). We aimed to evaluate the education and handling competence of patients in a real-world setting.

Materials And Methods: Patients with Hymenoptera venom allergy presenting for the first time in our clinic with a previously prescribed emergency kit including an AAI were interviewed using a standardized questionnaire and were asked to demonstrate the AAI use with a dummy.

Global remapping emerges as the mechanism for renewal of context-dependent behavior in a reinforcement learning model.

Introduction: The hippocampal formation exhibits complex and context-dependent activity patterns and dynamics, e.g., place cell activity during spatial navigation in rodents or remapping of place fields when the animal switches between contexts.

enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability.

The pore-forming enterotoxin (CPE), a common cause of foodborne diseases, facilitates Ca influx in enterocytes, leading to cell damage. Upon binding to certain claudins (e.g.

The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.

Experiences of caregiving-related adversity are common and one of the strongest predictors of internalizing psychopathology (i.e., anxiety and depression).

Inflammation and cognitive performance in elite athletes: A cross-sectional study.

Functional cognition is relevant for athletic success and interdependent with physical exercise, yet despite repeatedly demonstrated inflammatory responses to physical training, there are no studies addressing the relationship between cognition and inflammation in athletes. The aim of this study was to investigate the relationship between cognitive performance and selected inflammatory, and further physiological biomarkers in elite athletes. Data from 350 elite athletes regarding cognitive performance (processing speed, selective attention, working memory, cognitive flexibility), systemic inflammatory markers, metabolic hormones, growth factors, tissue damage markers, and micronutrients (e.

Analysis of engineered T7 bacteriophages containing genetic sequences encoding antimicrobial peptides.

Because of the global spread of multi- and pan-resistant bacteria, there is a need to identify, research, and develop new strategies to combat these pathogens. In a previous proof-of-concept study, we presented an innovative strategy by genetically modifying lytic T7 bacteriophages. We integrated DNA fragments encoding for derivatives of the antimicrobial peptide (AMP) apidaecin into the phage genome to induce the production and release of apidaecin within the T7 infection cycle, thereby also targeting phage-resistant bacteria.

Consistency and individuality of honeybee stinging behaviour across time and social contexts.

Whether individuals exhibit consistent behavioural variation is a central question in the field of animal behaviour. This question is particularly interesting in the case of social animals, as their behaviour may be strongly modulated by the collective. In this study, we ask whether honeybees exhibit individual differences in stinging behaviour.

Reconstruction of feeding behaviour and diet in Devonian ctenacanth chondrichthyans using dental microwear texture and finite element analyses.

Devonian ctenacanth chondrichthyans reached body sizes similar to modern great white sharks and therefore might have been apex predators of the Devonian seas. However, very little is known about the diet and feeding behaviours of these large ancestral sharks. To reconstruct their ecological properties, teeth of the large Famennian (Late Devonian) chondrichthyan from the Anti-Atlas, Morocco, were analysed.

Mental Health and the Intersection of Perceived Discrimination and Social Inequalities Among Students in Germany - a Quantitative Intersectional Study.

Objectives: Discrimination poses a threat to the mental health of university students, especially those affected by social inequality, yet understanding its intersectional impact remains limited. This study examines the intersection of social inequalities with perceived discrimination to explore differences in mental health among students in Germany.

Methods: Data from the cross-sectional project "Survey on study conditions and mental health of university students" (n = 14,592) were analysed using Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA).

Exploring factors that influence the behavior response to novel object tests in young thoroughbred horses: investigating sex, test site and auction history.

Introduction: The novel object test is one of the three most common fear tests in veterinary science and employed in several different species. Although having been applied in several different studies in horses, it is surprising that there is no standardized test procedure available for these kinds of tests.

Methods: This study investigated the performance of the novel object test on 42 young Thoroughbred horses to determine the effect of sex (mare or stallion), test sites (round pen or paddock) and whether the horses had previously participated in an auction or not on the behavior during the novel object test.

Effects of UV-B light exposure during automatic milking on vitamin D levels in Holstein Friesian cows.

Vitamin D is essential for cattle and can be synthesized in the skin under ultraviolet irradiation. This study investigated the effects of narrow-band UV-B irradiation during automatic milking on blood vitamin D concentration and the influence of hair and black skin areas on cutaneous vitamin D synthesis in Holstein Friesian cows. Fifty-one cows were stratified by milk yield, days after calving, and percentage of black skin, then divided into three groups: shaved and irradiated (80 J/m), unshaved and irradiated (129-305 J/m), and a control group.

A didactic illustration of writing skill growth through a longitudinal diagnostic classification model.

Introduction: Diagnostic classification models (DCMs) have received increasing attention in cross-sectional studies. However, L2 learning studies, tracking skill development over time, require models suited for longitudinal analyses. Growth DCMs offer a promising framework for such analyses.

Opportune moments for task interruptions: examining the cognitive mechanisms underlying interruption-timing effects.

Introduction: Several studies showed that task interruptions at high mental workload moments are more harmful than task interruptions at low mental workload moments. In the present study, we used a theory-driven approach to define the mental workload during primary-task execution and to examine the effects of the interruption timing on primary-task performance.

Methods: Participants performed a primary task comprising a pre-defined sequence of six subtasks, with task interruptions occasionally occurring before the second, third, or fourth subtasks.

Measuring the dark triad: a meta-analytical SEM study of two prominent short scales.

This research examines the factor structure and psychometric properties of two well-known Dark Triad personality trait questionnaires: the Short Dark Triad (SD3) and the Dirty Dozen (DD). By analyzing data from 11 (SD3) and 5 (DD) carefully selected studies in the United States and Canada, this meta-analysis uncovers unexpected correlations among questionnaire items, challenging existing assumptions. The study employs a two-stage structural equation modeling approach to evaluate various measurement models.

Economic methodology to preserve the past? Some reflections on .

Methodological appraisal usually aims at a discourse that contributes to the improvement of knowledge production processes in economics. Attempts by economists, such as that by Gilboa et al. (2022.

Morphology-Transport Coupling and Dissipative Structures in PEO-PS+LiTFSI Electrolytes In-Operando Conditions.

A Single-Chain-in-Mean-Field (SCMF) algorithm was introduced to study block copolymer electrolytes in nonequilibrium conditions. This method self-consistently combines a particle-based description of the polymer with a generalized diffusion equation for the ionic fluxes, thus exploiting the time scale separation between fast ion motion and the slow polymer relaxation and self-assembly. We apply this computational method to study ion fluxes in electrochemical cells containing poly(ethylene oxide)-polystyrene (PEO-PS) block copolymers with added lithium salt.

Arthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry data from an international perspective.

Background And Purpose:  The amount of information publicly available from arthroplasty registries is large but could be used more effectively. This project aims to improve the knowledge concerning existing registries to facilitate access, transparency, harmonization, and reporting.

Methods: Within the International Society of Arthroplasty Registries (ISAR) we aimed at developing, testing, adopting, and making publicly available a short, standardized registry description with items considered relevant for stakeholders using a cross-sectional study survey.

Socioeconomic characteristics and relapse-free and overall survival from childhood cancer - a nationwide study based on data from the Danish Childhood Cancer Registry.

Background And Purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nationwide register-based study, we assessed associations between parental socioeconomic position (SEP) and 5-year relapse-free survival (RFS) and overall survival (OS) in childhood cancer patients.

Lifetime Risks for Lung Cancer due to Occupational Radon Exposure: A Systematic Analysis of Estimation Components.

Lifetime risk estimates play a key role in many areas of radiation research. Here, the focus is on the lifetime excess absolute risk (LEAR) for dying from lung cancer due to occupational radon exposure based on uranium miners cohort studies. The major components in estimating LEAR were systematically varied to investigate the variability and uncertainties of results.

The specialty of oral and maxillofacial surgery (OMFS) in Europe - Part 2: training environment including the new Union of European Medical Specialists (UEMS) Oral and Maxillofacial Surgery European Training Requirement (OMFS ETR).

OMFS training in Europe has incrementally improved over the last 50 years. However, not all European nations have a formal written curriculum/syllabus, quality indicators, exit examinations, or guidelines for training programmes or trainers. In 2021 the OMFS Section of the Union of European Medical Specialists (UEMS) created an OMFS European Training Requirement (OMFS ETR) to help address these gaps and raise training standards in Europe.

The specialty of oral and maxillofacial surgery (OMFS) in Europe - Part 1: service configuration, regulation, and provision.

Oral and maxillofacial surgical (OMFS) practice and training in Europe is supported by the OMFS Section of the Union of European Medical Specialists (UEMS). Across Europe the number of OMFS specialists per 100,000 varies from 3.0 (Switzerland) to 0.