Development and validation of a sport-specific shoulder score questionnaire for functional fitness and weightlifting athletes.

Background: So-called scores are a frequently used evaluation system in clinical examinations to assess the function or limitations of a joint such as the shoulder. However, research indicates that these general scores often have limited validity for specific patient groups, such as athletes. Known as a demanding patient population, athletes have unique needs.

Associations Between the Neural Stress Response and Symptoms of Anxiety and Depression.

Anxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project.

Reversed valved Potts shunt for refractory primary pulmonary arterial hypertension.

This procedure is carried out via a full sternotomy using standard aortic and bicaval cannulations. For the aortic and pulmonary anastomoses, selective antegrade unilateral cerebral perfusion is used after cooling the body temperature to 26 °Celsius. A 12-mm Hancock conduit is interposed between the pulmonary artery and the proximal descending aorta using standard running suture techniques.

Catalytic effects of iron adatoms in poly(-phenylene) synthesis on rutile TiO(110).

-Armchair graphene nanoribbons (nAGNRs) are promising components for next-generation nanoelectronics due to their controllable band gap, which depends on their width and edge structure. Using non-metal surfaces for fabricating nAGNRs gives access to reliable information on their electronic properties. We investigated the influence of light and iron adatoms on the debromination of 4,4''-dibromo--terphenyl precursors affording poly(-phenylene) (PPP as the narrowest GNR) wires through the Ullmann coupling reaction on a rutile TiO(110) surface, which we studied by scanning tunneling microscopy and X-ray photoemission spectroscopy.

Is Kaposi sarcoma a novel comorbidity of cutaneous lymphoma? A systematic review of the literature.

Background And Objectives: Patients with cutaneous lymphomas (CL) are at an increased risk of developing secondary malignancies. This study aimed to assess the frequency of association between CL and Kaposi sarcoma (KS) and to identify factors that may promote the co-occurrence of these two diseases.

Patients And Methods: On January 25, 2024, we conducted a systematic search of four electronic medical databases to identify all published cases of KS associated with CL.

Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.

The main protease M is a clinically validated target to treat infections by the coronavirus SARS-CoV-2. Among the first reported M inhibitors was the peptidomimetic α-ketoamide , whose cocrystal structure with M paved the way for multiple lead-finding studies. We established structure-activity relationships for the series by modifying residues at the P1', P3, and P4 sites.

Identification of dissipation pathways for pharmaceuticals in soils - a modelling approach.

Concentrations of pollutants like pharmaceuticals in soils typically decrease over time, though it often remains unclear whether this dissipation is caused by the transformation of the pollutant or a decreasing extractability. We developed a mathematical model that (1) explores the plausibility of different dissipation pathways, and (2) allows the quantification of concentration differences between aqueous soil extracts and soil solution. The model considers soil particles as uniform spheres, kinetic sorption towards an equilibrium (Freundlich model), and two dissipation pathways, irreversible transformation and mineralization (following 1 order kinetics) as well as the formation of non-extractable residues intraparticle diffusion.

Bernoulli trial under subsystem restarts: Two competing searchers looking for a target.

We study a pair of independent searchers competing for a target under restarts and find that introduction of restarts tends to enhance the search efficiency of an already efficient searcher. As a result, the difference between the search probabilities of the individual searchers increases when the system is subject to restarts. This result holds true independent of the identity of individual searchers or the specific details of the distribution of restart times.

Reactivation of latent HIV-1 by the glucocorticoid receptor modulator AZD9567.

One key determinant of HIV-1 latency reversal is the activation of the viral long terminal repeat (LTR) by cellular transcription factors such as NF-κB and AP-1. Interestingly, the activity of these two transcription factors can be modulated by glucocorticoid receptors (GRs). Furthermore, the HIV-1 genome contains multiple binding sites for GRs.

Pulsed-Current Operation Enhances HO Production on a Boron-Doped Diamond Mesh Anode in a Zero-Gap PEM Electrolyzer.

A niobium (Nb) mesh electrode was coated with boron-doped diamond (BDD) using chemical vapor deposition in a custom-built hot-filament reactor. The BDD-functionalized mesh was tested in a zero-gap electrolysis configuration and evaluated for the anodic formation of HO by selective oxidation of water, including the analysis of the effects on Faradaic efficiency towards HO (FEH2O2) induced by pulsed electrolysis. A low electrolyte flow rate (V⋅) was found to result in a relatively high concentration of HO in single-pass electrolysis experiments.

Interplay of SHH, WNT and BMP4 signaling regulates the development of the lamina propria in the murine ureter.

In the mammalian ureters, the lamina propria presents as a prominent layer of connective tissue underneath the urothelium. Despite its important structural and signaling functions, little is known how the lamina propria develops. Here, we show that in the murine ureter, the lamina propria arises at late fetal stages and massively increases by fibrocyte proliferation and collagen deposition after birth.

Characterization by LC-MS/MS analysis of KLH vaccine conjugated with a tick antigen peptide.

Keyhole limpet haemocyanins (KLH1 and KLH2) from , are multi-subunit oxygen-carrying metalloproteins of approximately 3900 amino acids, that are widely used as carrier proteins in conjugate vaccines and in immunotherapy. KLHs and their derived conjugate vaccines are poorly characterized by LC-MS/MS due to their very stable supramolecular structures with megadalton molecular mass, and their resistance to efficient digestion with standard protocols. KLH1 and KLH2 proteins were conjugated to the conserved P0 peptide (pP0), derived from the P0 acidic ribosomal protein of sp.

Open-label, phase Ia study of STING agonist BI 1703880 plus ezabenlimab for patients with advanced solid tumors.

BI 1703880, a novel STimulator of INterferon Genes (STING) agonist, has demonstrated preclinical antitumor activity. As STING activation can upregulate programmed death ligand 1 and human leukocyte antigen in tumor cells, a combination of BI 1703880 and an anti-programmed cell death protein 1-antibody, such as ezabenlimab, may improve efficacy. This first-in-human phase Ia study (NCT05471856) is evaluating BI 1703880 plus ezabenlimab in patients with advanced solid tumors.

A unified approach to SimpleTreat input and settings for wastewater treatment removal predictions.

SimpleTreat has become a common tool used in ecological risk assessments to estimate the removal efficiency of a chemical from a secondary wastewater treatment plant and hence inform on release to the environment. Organization A, Organization B, and Organization C performed a comparative study of SimpleTreat predictions and parameter selection methodologies across the three organizations. SimpleTreat versions 3.

A proposal on bird focal species selection for higher tier risk assessments of plant protection products in the EU.

The revised EFSA 2023 Guidance on the risk assessment of plant protection products for birds and mammals emphasises vulnerability as a relevant criterion for focal species (FS) selection rather than prevalence. The EFSA 2023 Guidance suggests to rank FS candidates for each dietary group according to their expected exposure by estimating a species-specific daily dietary dose (DDD). Species experiencing higher exposure would be ranked as potentially more vulnerable and can be identified as FS candidates.

2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitors.

The inhibition of human microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is a promising therapeutic modality for developing next-generation anti-inflammatory medications. In this study, we present novel 2-phenylbenzothiazole derivatives featuring heteroaryl sulfonamide end-capping substructures as inhibitors of human mPGES-1, with IC values in the range of 0.72-3.

Right-wing authoritarianism and perceptions that minoritized groups pose a threat: The moderating roles of individual- and country-level religiosity and marginalization.

Right-wing authoritarianism (RWA) refers to an adherence to conventional values and authorities with the power to penalize groups that are perceived to challenge the cohesion of ingroup norms. Correspondingly, RWA has repeatedly been linked to negative perceptions of minoritized groups, such as refugees or religious minorities. To investigate whether and how sociocultural factors add to and moderate how RWA influences perceptions that minoritized groups pose a threat (i.

Studying Kurdishness in Turkey: A review of existing research.

Knowledge production on marginalized identities is frequently shaped by epistemic violence, which limits both the scope and methodologies of research. One example of this is the case of Kurdish identity in Turkey, where we find that methodological and epistemic problems are evident particularly in social psychological research. To summarize social psychological studies on Kurdishness, Kurdish identity and conflict in Turkey we've conducted a systematic review that includes a total of 63 studies on topics related to Kurdishness.

Trifunctional lipid derivatives: PE's mitochondrial interactome.

Phosphatidylethanolamine (PE) is a ubiquitous lipid species in higher eukaryotes. Here, we synthesized a multifunctionalized PE derivative (1) designed to identify PE-binding proteins in intact cells through photo-crosslinking and subsequent isolation and proteomic analysis of the PE-protein conjugates. We show that the tool is also useful for tracking PE translocation to mitochondria after uncaging.

Molecular Insights into the Adsorption of Deposit Control Additives from Hydrocarbon Fuels.

Engine deposits can reduce performance and increase emissions, particularly for modern direct-injection fuel delivery systems. Surfactants known as deposit control additives (DCAs) adsorb and self-assemble on the surface of deposit precursors to keep them suspended in the fuel. Here, we show how molecular simulations can be used to virtually screen the ability of surfactants to bind to polyaromatic hydrocarbons, comprising a major class of carbonaceous deposits.

The orientational structure of a model patchy particle fluid: Simulations, integral equations, density functional theory, and machine learning.

We investigate the orientational properties of a homogeneous and inhomogeneous tetrahedral four-patch fluid (Bol-Kern-Frenkel model). Using integral equations, either (i) HNC or (ii) a modified HNC scheme with a simulation input, the full orientational dependence of pair and direct correlation functions is determined. Density functionals for the inhomogeneous problem are constructed via two different methods.

Kohn-Sham inversion for open-shell systems.

Methods based on density-functional theory usually treat open-shell atoms and molecules within the spin-unrestricted Kohn-Sham (KS) formalism, which breaks symmetries in real and spin space. Symmetry breaking is possible because the KS Hamiltonian operator does not need to exhibit the full symmetry of the physical Hamiltonian operator, but only the symmetry of the spin density, which is generally lower. Symmetry breaking leads to spin contamination and prevents a proper classification of the KS wave function with respect to the symmetries of the physical electron system.

Prognostic Implications of Sex in Patients With Heart Failure With Mildly Reduced Ejection Fraction: Results From a Large-Scaled Registry.

Background: The study investigates the prognostic impact of sex and sex-related differences in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). More data regarding the characterization of patients and their outcomes in the presence of HFmrEF are needed.

Methods And Results: Consecutive patients hospitalized with HFmrEF (ie, left ventricular ejection fraction 41%-49% and signs or symptoms of HF) were retrospectively included at one institution from 2016 to 2022.

Oligoethylene Phosphoramidate-based Kinase Inhibitor Prodrugs - Solubility, Enzyme Inhibition, and Hydrolysis.

The efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave these after reaching the target is important to make use of the therapeutic effects of the native drug. Moreover, the length of the PEG chains will have an effect on the solubility and binding.