1,541,027 results match your criteria: "Germany; German Federal Institute for Risk Assessment BfR[Affiliation]"
EClinicalMedicine
August 2024
Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Background: Despite the immense impact of Long COVID on public health and those affected, its aetiology remains poorly understood. Findings suggest that psychological factors such as depression contribute to symptom persistence alongside pathophysiological mechanisms, but knowledge of their relative importance is limited. This study aimed to synthesise the current evidence on psychological factors potentially associated with Long COVID and condition-relevant outcomes like quality of life.
View Article and Find Full Text PDFEClinicalMedicine
August 2024
Section Health Equity Studies & Migration, Department of Primary Care and Health Services Research, Heidelberg University Hospital, Im Neuenheimer Feld 130.3, Heidelberg 69120, Germany.
Background: Evidence amounted early that migrants, who are often side-lined in pandemic response or preparedness plans, are disproportionately affected by the COVID-19 pandemic and its consequences. However, synthesised evidence that quantifies the magnitude of inequalities in infection risk, disease outcomes, consequences of pandemic measures or that explains the underlying mechanisms is lacking.
Methods: We conducted a systematic review searching 25 databases and grey literature (12/2019 to 09/2023) and considered empirical articles covering migrants, refugees, asylum-seekers, and internally displaced persons reporting COVID-19 cases, hospitalisation, ICU admission, mortality, COVID-19 vaccination rates or health consequences of pandemic measures.
Front Psychol
December 2024
Department of Industrial/Organizational and Social Psychology, Institute of Psychology, Technical University Braunschweig, Braunschweig, Germany.
Companies have to undergo many change processes to succeed in the transforming economy. However, many change processes fail because employees are insufficiently accompanied through the process in a targeted manner. This study of N = 427 employees from a steel industry company undergoing a transformation process examines whether the organizational readiness for change (ORC) of highly affected employees can be classified into profiles, how these profiles can be predicted by various antecedents, and whether outcome variables such as job satisfaction can be explained by profile membership.
View Article and Find Full Text PDFFront Immunol
December 2024
Periodontics Department, Dental College of Georgia, Augusta University, Augusta, GA, United States.
Front Immunol
January 2025
Department of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital Bonn, Bonn, Germany.
Objectives: This study aimed to evaluate the diagnostic utility of [Ga]Ga-DOTA-Siglec-9 positron emission tomography-computed tomography (PET/CT) in assessing disease activity in a patient experiencing a relapse of giant cell arteritis (GCA).
Case Presentation: A 90-year-old male patient with GCA, diagnosed in 2018, was enrolled. Demographic data, disease history, and laboratory parameters, including soluble VAP-1 (sVAP-1) levels, were recorded.
Front Immunol
January 2025
Translational Radiobiology Lab, Department of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany.
Background: Esophageal cancer has a poor prognosis despite treatment advancements. Although the benefit of neoadjuvant chemoradiotherapy (CRT) followed by adjuvant immunotherapy is evident, the effects of CRT on PD-L1 expression in esophageal cancer are not well understood. This study examines the impact of neoadjuvant CRT on PD-L1 surface expression in esophageal cancer both and considering its implications for immunotherapy.
View Article and Find Full Text PDFLancet Reg Health Am
December 2024
Institute of the History of Medicine, University Justus Liebig Giessen, Leihestener Weg 52, Giessen 35392, Germany.
Stigma and discrimination-based narratives have been associated with adverse health outcomes. Migrants and refugees face multiple barriers to accessing healthcare, influenced by stigma and discrimination-based narratives against them. We conducted a scoping review of scientific and grey literature (n = 61) to discuss available evidence in Latin America and the Caribbean (LAC) concerning communication and narrative speeches related to international migration and its implications for population health, particularly when associated with stigma and discrimination against migrants and refugees.
View Article and Find Full Text PDFLancet Reg Health Am
December 2024
Latin American Centre of Excellence for Climate Change and Health, Universidad Peruana Cayetano Heredia, San Martín de Porres, 15102, Peru.
This article delves into the complex relationship between climate change, migration patterns, and health outcomes in Latin America and the Caribbean (LAC). While the severe impact of climate change on health in LAC is widely acknowledged, the article sheds light on the often-overlooked multiple effects on migration and the well-being of migrants. These impacts encompass poverty, food and water insecurity, and adverse physical and mental health outcomes.
View Article and Find Full Text PDFFront Sports Act Living
December 2024
Faculty of Business Management & Social Sciences, Hochschule Osnabrück, University of Applied Sciences, Osnabrück, Germany.
Introduction: While the impact of anthropogenic climate change on sports and the subsequent need for adaptation to evolving climatic conditions are acknowledged, there remains a notable paucity of scientific inquiry within the realm of sports and sports event studies specifically addressing climate change and its ramifications for event planning and management. Existing studies predominantly stem from health, medical, weather and climate science and mostly focus on mega-events and elite athlete contexts. Moreover, they often only focus on one specific impact (e.
View Article and Find Full Text PDFAll-solid-state Li-ion batteries (ASSBs) represent a promising leap forward in battery technology, rapidly advancing in development. Among the various solid electrolytes, argyrodite thiophosphates Li6PS5X (X = Cl, Br, I) stand out due to their high ionic conductivity, structural flexibility, and compatibility with a range of electrode materials, making them ideal candidates for efficient and scalable battery applications. However, despite significant performance advancements, the sustainability and recycling of ASSBs remain underexplored, posing a critical challenge for achieving efficient circular processes.
View Article and Find Full Text PDFLab Chip
January 2025
Nanobioelectronics Laboratory (NBEL), Department of Biomedical Engineering, Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, 8410501 Beer Sheva, Israel.
Dissolved oxygen is crucial for metabolism, growth, and other complex physiological and pathological processes; however, standard physiological models (such as organ-on-chip systems) often use ambient oxygen levels, which do not reflect the lower levels that are typically found . Additionally, the local generation of reactive oxygen species (ROS; a key factor in physiological systems) is often overlooked in biology-mimicking models. Here, we present a microfluidic system that integrates electrochemical dissolved oxygen sensors with lab-on-a-chip technology to monitor the physiological oxygen concentrations and generate hydrogen peroxide (HO; a specific ROS).
View Article and Find Full Text PDFBr J Psychiatry
January 2025
Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, Australia.
Background: Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties.
Aims: To investigate if subcutaneous racemic ketamine, delivered twice weekly for 4 weeks, reduces anxiety in people with TRD.
Interv Neuroradiol
January 2025
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Background: Pretreatment CT perfusion (CTP) marker relative cerebral blood volume (rCBV) < 42% lesion volume has recently shown to predict poor collateral status and poor 90-day functional outcome. However, there is a paucity of studies assessing its association with hemorrhagic transformation (HT). Here, we aim to assess the relationship between rCBV < 42% lesion volume with HT.
View Article and Find Full Text PDFJ Dent Educ
January 2025
Department of Prosthodontics, Martin Luther University Halle-Wittenberg, Halle, Germany.
Health Econ Policy Law
January 2025
Economics & Law Department, Frankfurt School of Finance & Management, Frankfurt, Germany.
This study aimed to compare reimbursement prices for new, innovative non-orphan drugs in Germany based on price negotiation and cost-effectiveness analysis, using the efficiency frontier (EF) approach and cost-utility analysis (CUA). For the EF, the next effective intervention and no intervention were used as comparators. Three pairwise comparisons were conducted: negotiation vs EF, CUA vs EF and negotiation vs CUA.
View Article and Find Full Text PDFAliment Pharmacol Ther
January 2025
Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Cardiol Young
January 2025
Department of Pediatric Cardiology, Intensive Care Medicine and Congenital Heart Disease, Justus Liebig University, Giessen, Germany.
Background: A subgroup of CHDs can only be treated palliatively through a Fontan circulation. In case of a failing Fontan situation, serum proteins are lost unspecifically and can also lead to a loss of vaccine antibodies. In a failing Fontan situation, heart transplantation may be the only feasible option.
View Article and Find Full Text PDFJ Org Chem
January 2025
Universität Rostock, Institut für Chemie, A.-Einstein-Str. 3a, 18059 Rostock, Germany.
Novel π-expanded and N-doped fluoranthenes were synthesized and thoroughly investigated. These eight unsubstituted compounds are obtained in a multistep synthesis with CH activation as the last key reaction step. The structures vary in their position of π-expansion on the fluoranthene scaffold and the location of the pyridinic nitrogen atom.
View Article and Find Full Text PDFCereb Cortex
January 2025
Institute of Neuroscience and Medicine (INM-3), Research Center Juelich, Forschungszentrum Jülich, Wilhelm-Johnen-Strasse, 52425 Jülich, Germany.
More than a decade ago, the introduction of intubation and mechanical ventilation for performing blood oxygen level-dependent functional MRI studies in the rodent brain allowed an improved control over the physiological conditions during scanning sessions. An accurate understanding of respiratory parameters permits to respect the 3Rs in animal research, improves significantly the fMRI outcome, and promises improved translational studies. Developments also prompted a better comprehension on anesthetics and their impact on rodent brain physiology and function, bringing new insights on the buildup of carbon dioxide, interhemispheric connectivity, or arousal, which understanding are paramount for maturing better fMRI protocols in awake rodents.
View Article and Find Full Text PDFAdv Mater
January 2025
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, P. R. China.
Effective modifications for the buried interface between self-assembled monolayers (SAMs) and perovskites are vital for the development of efficient, stable inverted perovskite solar cells (PSCs) and their tandem photovoltaics. Herein, an ionic-liquid-SAM hybrid strategy is developed to synergistically optimize the uniformity of SAMs and the crystallization of perovskites above. Specifically, an ionic liquid of 1-butyl-3-methyl-1H-imidazol-3-iumbis((trifluoromethyl)sulfonyl)amide (BMIMTFSI) is incorporated into the SAM solution, enabling reduced surface roughness, improved wettability, and a more evenly distributed surface potential of the SAM film.
View Article and Find Full Text PDFNew Phytol
January 2025
Department of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829, Cologne, Germany.
Karyotype changes are a formidable evolutionary force by directly impacting cross-incompatibility, gene dosage, genetic linkage, chromosome segregation, and meiotic recombination landscape. These changes often arise spontaneously and are commonly detected within plant lineages, even between closely related accessions. One element that can influence drastic karyotype changes after only one (or few) plant generations is the alteration of the centromere position, number, distribution, or even its strength.
View Article and Find Full Text PDFWorld J Biol Psychiatry
January 2025
P1vital, Wallingford, UK.
Objectives: While neuropsychological effects of conventional antidepressants are well-documented, more research is needed for rapid-acting antidepressants. This study examines the effects of esketamine on emotion processing and cognitive functioning, both acutely and sub-chronically.
Methods: Eighteen treatment-resistant depression (TRD) patients received repeated intravenous esketamine infusions.
J Anesth Analg Crit Care
January 2025
electroCore, Rockaway, NJ, USA.
Acta Neuropathol Commun
January 2025
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Recent genomic studies have allowed the subdivision of intracranial ependymomas into molecularly distinct groups with highly specific clinical features and outcomes. The majority of supratentorial ependymomas (ST-EPN) harbor ZFTA-RELA fusions which were designated, in general, as an intermediate risk tumor variant. However, molecular prognosticators within ST-EPN ZFTA-RELA have not been determined yet.
View Article and Find Full Text PDFDiabetes Obes Metab
January 2025
Eli Lilly and Company, Indianapolis, Indiana, USA.
Aims: To explore the relationship between weight loss and insulin sensitivity in response to tirzepatide or semaglutide.
Materials And Methods: We conducted a post hoc exploratory analysis of a 28-week, double-blind, randomized trial in people with type 2 diabetes treated with metformin, randomized to tirzepatide 15 mg, semaglutide 1 mg or placebo. We evaluated the relationship between change in body weight and change in insulin sensitivity determined from hyperinsulinemic euglycemic clamp (M value), or from mixed-meal tolerance testing (Matsuda index).