Establishing the Research Priorities of ADHD Professionals: An International Delphi Study.

Objectives: To determine ADHD research priorities from the perspective of ADHD professionals internationally.

Method: A two-stage modified Delphi design was used. In Stage 1 (qualitative), participants listed research questions relating to ADHD that they perceived to be most important ( = 132).

Association between BMI and cause-specific long-term mortality in acute myocardial infarction patients.

Aims: To investigate the association between body mass index (BMI) at acute myocardial infarction (AMI) and all-cause as well as cause-specific long-term mortality.

Methods: The analysis was based on 10,651 hospitalized AMI patients (age 25-84 years) recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. The median follow-up time was 6.

Intraoperative patient-specific volumetric reconstruction and 3D visualization for laparoscopic liver surgery.

Despite the benefits of minimally invasive surgery, interventions such as laparoscopic liver surgery present unique challenges, like the significant anatomical differences between preoperative images and intraoperative scenes due to pneumoperitoneum, patient pose, and organ manipulation by surgical instruments. To address these challenges, a method for intraoperative three-dimensional reconstruction of the surgical scene, including vessels and tumors, without altering the surgical workflow, is proposed. The technique combines neural radiance field reconstructions from tracked laparoscopic videos with ultrasound three-dimensional compounding.

The impact of COVID-19 on accelerating of immunosenescence and brain aging.

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global health, affecting not only the immediate morbidity and mortality rates but also long-term health outcomes across various populations. Although the acute effects of COVID-19 on the respiratory system have initially been the primary focus, it is increasingly evident that the virus can have significant impacts on multiple physiological systems, including the nervous and immune systems. The pandemic has highlighted the complex interplay between viral infection, immune aging, and brain health, that can potentially accelerate neuroimmune aging and contribute to the persistence of long COVID conditions.

The relationship between perfectionism and marital outcomes: a systematic review and meta-analysis.

Introduction: Perfectionism, as a transdiagnostic variable, can influence both the intrapersonal and interpersonal domains, one of the most significant of them is thought to be marital relationship. Given that perfectionism within a couple can negatively affect their intimate relationship and potentially lead to destructive outcomes, reviewing studies conducted in this area seems to be essential to gain a clearer understanding. Therefore, the present systematic review aims to examine the association between perfectionism and marital outcomes in married individuals.

Strangers in a strange land: how diversity professionals navigate their marginal leadership identity.

The purpose of the present study was to understand how executives responsible for Diversity and Inclusion construct their identities while occupying positions of "Marginal Leadership," and how they deal with threats to such identities. We conducted qualitative and inductive research with Brazilian executives in 66 organizations, focusing on their experiences as leaders. In our resulting model, we theorized that leaders in positions of Marginal Leadership demonstrate little role clarity, resources, and confidence for the exercise of their activities, suffering threats to their identities, which are not observed in executives occupying positions in more traditional functions such as Finance, Production, and Marketing.

Effects of computer-generated patterns with different temporal and spatial frequencies on choroidal thickness, retinal dopamine and candidate genes in chickens wearing lenses.

Purpose: Changes in choroidal thickness (ChT) are proposed to predict myopia development but evidence is mixed. We investigated time courses of choroidal responses, following different types of dynamic artificial stimulation in chicks with and without spectacle lenses, as well as changes in retinal dopamine metabolism and expression of candidate genes.

Methods: Chicks were kept in an arena surrounded by computer monitors presenting dynamic checkerboard fields of small, medium and large size.

Exploring a new chapter in traditional Chinese medicine: The potential of in liver cancer treatment.

In the ongoing quest for new treatments in medicine, traditional Chinese medicine offers unique insights and potential. Recently, studies on the ability of to inhibit M2-type tumour-associated macrophage polarisation by modulating the Wnt/β-catenin signalling pathway to suppress liver cancer have undoubtedly revealed new benefits and hope for this field of research. The purpose of this article is to comment on this study and explore its strengths and weaknesses, thereby providing ideas for the future treatment of liver cancer.

Advancements and challenges in the treatment of esophageal cancer: A comprehensive review.

Esophageal cancer (EC) is an aggressive malignancy with a poor prognosis, ranking seventh in incidence and sixth cancer-related deaths globally. EC is classified in two main types, the esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), with ESCC being more common in Eastern Europe, South Asia, and Africa, while EAC is prevalent in Western Europe and North America. Molecular analysis identifies three subgroups of ESCC, each with distinct genetic mutations and treatment responses.

Unveiling the Threat to Vulture Diversity: A Comprehensive Ethno-Ornithological Study Uncovers Regional Trade Effects in Côte d'Ivoire.

In recent decades, African vulture populations have experienced a distressing decline, with certain species plummeting by over 90%. This decline can largely be attributed to various human-induced pressures. In West Africa, the trade of vultures for magico-traditional medicine stands out as a significant threat.

Novel type 2 diabetes prediction score based on traditional risk factors and circulating metabolites: model derivation and validation in two large cohort studies.

Background: We aimed to evaluate the incremental predictive value of metabolomic biomarkers for assessing the 10-year risk of type 2 diabetes when added to the clinical Cambridge Diabetes Risk Score (CDRS).

Methods: We utilized 86,232 UK Biobank (UKB) participants (recruited between 13 March 2006 and 1 October 2010) for model derivation and internal validation. Additionally, we included 4383 participants from the German ESTHER cohort (recruited between 1 July 2000 and 30 June 2002 for external validation).

Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017.

Background: Ovarian cancer (OC) is a heterogeneous malignancy with multiple histological subtypes, showing global variability in incidence. Temporal changes in diagnostic criteria and risk factors might influence the incidence and distribution of OC and its subtypes.

Methods: This study analyzed incidence patterns (2013-2017) and trends (1988-1992 to 2013-2017) of OC and its subtypes across 65 and 40 countries, respectively.

Erratum: Real-life efficacy of immunotherapy for Sézary syndrome: a multicenter observational cohort study.

[This corrects the article DOI: 10.1016/j.eclinm.

AI education for clinicians.

Rapid advancements in medical AI necessitate targeted educational initiatives for clinicians to ensure AI tools are safe and used effectively to improve patient outcomes. To support decision-making among stakeholders in medical education, we propose three tiers of medical AI expertise and outline the challenges for medical education at different educational stages. Additionally, we offer recommendations and examples, encouraging stakeholders to adapt and shape curricula for their specific healthcare setting using this framework.

Minimally Invasive Mitral Valve Repair with Intercostal Cryoablation: A Case Report.

 Minimally invasive lateral thoracotomies may cause severe postoperative pain and discomfort. We describe an intraoperative intercostal cryo-neuronal pain block as one possibility for postoperative pain relief.  A 63-year-old male patient underwent minimally invasive mitral valve repair.

A Firing Cannon: Bilateral Lower Limb Ischemia as a Manifestation of Cardiac Myxoma.

 Cardiac myxomas are the most common primary cardiac neoplasms.  We present a case of a middle-aged lady with cardiac myxoma in her left atrium awaiting semi-elective surgery. During the preoperative period, the patient presented emergently with acute bilateral lower limb ischemia.

The fruit fly as a screening model for antiseizure medications.

Objective: Resistance to antiseizure medications (ASMs) is a major challenge in the treatment of patients with epilepsy. Despite numerous newly marketed ASMs, the proportion of drug-resistant people with epilepsy has not significantly decreased over the years. Therefore, novel and innovative seizure models for preclinical drug screening are highly desirable.

Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.

Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health.

PRIO - a prospective integrative oncology registry: trial protocol.

Background: Integrative Oncology (IO) - the use of lifestyle modifications, mind-body practices and natural products in oncology - is increasingly asked for by patients. The evidence base of IO is growing and IO measures are included in national guidelines. Still, many questions about IO remain unanswered or still show a poor evidence base.

Improved survival of patients with newly diagnosed oligometastatic prostate cancer through intensified multimodal treatment.

Background And Objectives: The standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT), novel antihormonal therapies (NHT) and/or chemotherapy. Patients with newly diagnosed oligometastatic prostate cancer (omPCa) represent a distinct subgroup of mHSPC, for which the optimal treatment, particularly the role of radical prostatectomy (RP) and metastasis-directed therapy (MDT), is currently under debate.

Materials And Methods: In this single center, retrospective analysis, 43 patients with newly diagnosed omPCa were included.

Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease.

Accumulating evidence demonstrates that alpha-synuclein (α-syn) pathology associated with Parkinson's disease (PD) is not limited to the brain, as it also appears in a select number of peripheral tissues including the liver. In this study, we identified a number of PD-associated α-syn post-translational modifications in the livers of (Thy-1)-h[A30P] mice, a mouse model of familial PD expressing human α-syn harboring the A30P mutation driven by a neuron-specific promoter. , we also demonstrate that human hepatocytes induce post-translational modifications following α-syn fibrillar (PFF) treatment.

SLP2 and MIC13 synergistically coordinate MICOS assembly and crista junction formation.

The MICOS complex, essential for cristae organization, comprises MIC10 and MIC60 subcomplexes, with MIC13 as a crucial subunit. mutations cause severe mitochondrial hepato-encephalopathy, cristae defects, and MIC10-subcomplex loss. We demonstrate that depletion of the mitochondrial protease YME1L in KO stabilizes MIC10-subcomplex, restoring MIC60-MIC10 interaction and crista junction (CJ) defects, indicating MIC13 is crucial for MIC10-subcomplex stabilization rather than MIC60-MIC10 bridging.

Sophisticated perspective-takers are distinctive: Neural idiosyncrasy of functional connectivity in the mentalizing network.

Naive perspective-takers often perceive the social world in a simplistic and uniform way, whereas sophisticated ones recognize the diversity and complexity of others' minds. This commonly accepted distinction points to a possibility of greater inter-individual variability in mentalizing for sophisticated than naive perspective-takers, a difference previously overlooked in research. In the current study, participants were asked to watch a mentalizing-related movie and their neural responses, interpretations of the characters' mental states, and eye-gaze trajectories were recorded.

"ICODE Hip US Calculator": a mobile phone aid for screening with Graf's sonographic technique.

Aim: Aiming to offer a diagnostic tool to aid examiners with correct hip typing and decision-making about patient management, members of the Board of the International Interdisciplinary Consensus Committee on DDH Evaluation (ICODE - https://www.icode.expert), introduced the cross-platform mobile application (Android and iOS) called "ICODE Hip US Calculator".

Feasibility, Safety, and Clinical Performance of Self-apposing Stents for Left Main Stenosis.

Drug-eluting stents (DES) are the gold standard for percutaneous coronary interventions (PCI); however, technical and anatomical challenges need to be addressed to ensure optimal apposition and prevent late adverse events. Complex vessel anatomies, including ectatic or aneurysmatic vessels, or significant differences in diameter in left main stenosis of the coronary artery, are clinical indications in which current PCI techniques attempt to shape conventional DES to follow vessel anatomy, thus modifying the original stent scaffold and its properties. However, due to their design, balloon-expandable cobalt-chromium and cobalt-nickel DES have limitations regarding their expansion capacity, which can result in undersizing and malapposition.