Drug Development.

Numerous drugs (including disease-modifying therapies, cognitive enhancers and neuropsychiatric treatments) are being developed for Alzheimer's and related dementias (ADRD). Emerging neuroimaging modalities, and genetic and other biomarkers potentially enhance diagnostic and prognostic accuracy. These advances need to be assessed in real-world studies (RWS).

Dementia Care Research and Psychosocial Factors.

Background: Using artificial intelligence approaches enable automated assessment and analysis of speech biomarkers for Alzheimer's disease, for example using chatbot technology. However, current chatbots often are unsuitable for people with cognitive impairment. Here, we implemented a user-centred-design approach to evaluate and improve usability of a chatbot system for automated speech assessments for people with preclinical, prodromal and early dementia.

Dementia Care Research and Psychosocial Factors.

Background: Given that the majority of people with dementia live in their homes in the community and are primarily cared for by informal caregivers, there is a growing interest in developing interventions suitable for this setting. Further, it is important to establish how music selections can differentially affect PwD. In this pilot trial, we thus compare two caregiver-delivered music listening MBIs with care-as-usual.

Dementia Care Research and Psychosocial Factors.

Background: Due to further development of diagnostic methods of early-stage diagnosis of Alzheimer's disease (AD) and new disease-modifying treatment options that require early diagnosis, a new focus on predictive and preventive medicine arises. With progress in AD dementia risk estimation, guidelines for counseling, considering individual aspects of those affected, are becoming more important. As part of the trinational project PreTAD (The Predictive Turn in Alzheimer's Disease: Ethical, Clinical, Linguistic and Legal Aspects) anticipated effects of AD dementia risk estimation for first-degree relatives of people with AD dementia are evaluated.

Dementia Care Research and Psychosocial Factors.

Background: The aim of the present study was twofold: First, to examine the validity of previously reported sociodemographic (age, sex) and clinical predictors (cognitive status, functional status, comorbidities) for the life expectancy in people with dementia in a community sample. Second, to investigate the role of social support beyond individual predictors.

Method: The study utilizes data from 500 individuals living in the community who were diagnosed with dementia.

Dementia Care Research and Psychosocial Factors.

Background: Physical exercise presents a viable low-cost, low-risk, individual, and widely available non-pharmacological treatment candidate in cognitive decline such as in Alzheimer's disease (AD). There are even indications that it can reduce the risk of developing dementia in the first place (Livingston et al., The Lancet, 2020).

Dementia Care Research and Psychosocial Factors.

Background: Projected Alzheimer's disease (AD) prevalence is expected to fourfold by 2050. With the escalating numbers of individuals affected by neurodegenerative diseases, including Parkinson's disease (PD) and AD, associated challenges encompass increased burdens on individuals and families, societal and political implications and economic impacts. Integrating patient and caregiver perspectives is essential to creating comprehensive, patient-centered care models that promote well-being and resilience in the face of degenerative neurological diseases such as AD.

Dementia Care Research and Psychosocial Factors.

Background: Participatory research or patient and public involvement refer to the process of actively involving people with lived experience into the research process to improve its relevance, quality, and impact. In the PART project we aim to establish a sustainable structure to include underrepresented patient groups with neurodegenerative diseases into a patient advisory board for research. As one of our milestones, we conducted a systematic literature review with the aim of examining the impact of participatory research on people involved, such as those with cognitive impairment, caregivers, and researchers.

Dementia Care Research and Psychosocial Factors.

Background: Proxy ratings primarily provided by informal caregivers are usually administered if patients living with dementia (PlwD) are cognitively unable to rate health independently. The literature is limited by the use of typically agreement statistics, reporting that proxies generally underestimate PlwD health. Additional analyses of self- and proxy-rated discrepancies in individual responses that focus on HRQoL dimensions are lacking.

Dementia Care Research and Psychosocial Factors.

Background: Driven by (bio-)medical and technical developments, advanced non-invasive methods for estimating the risk of Alzheimer's dementia (ADD) are increasingly emerging. In the future, such methods could eventually become available for individuals in asymptomatic and preclinical stages of Alzheimer's disease (e.g.

Dementia Care Research and Psychosocial Factors.

Background: Previous trials reported that collaborative Dementia Care Management (cDCM) could be effective for patients and caregivers and cost-effective for healthcare systems in the short term. However, long-term evidence is lacking. Therefore, the study's objective was to determine the long-term efficacy and cost-effectiveness of cDCM compared with usual care.

Dementia Care Research and Psychosocial Factors.

Background: Approximately 1.8 million individuals in Germany live with dementia, imposing a substantial burden on family caregivers who provide most care and often experience health issues, social isolation, and diminished quality of life. Recognizing and addressing the diverse needs of these caregivers is vital for their well-being and the stability of care arrangements.

Dementia Care Research and Psychosocial Factors.

Background: Environmental factors account for a considerable percentage of dementia cases. Studies in animal models have shown that environmental enrichment (EE; i.e.

Dementia Care Research and Psychosocial Factors.

Background: Promising elements of assistive technologies are available to help people with cognitive impairment in their daily lives. However, there has been limited research on how smartwatches can directly interact with persons who have cognitive impairments. We looked at the factors that affect the effectiveness of interventions provided via a smartwatch.

Dementia Care Research and Psychosocial Factors.

Background: The number of people with dementia increases worldwide. Previous studies have shown that social integration and high-quality social relationships are beneficial for reducing dementia risk and improving symptoms. Our project aimed at identifying characteristics of the social environment of people with dementia (PWD) and their relevance for PWDs' wellbeing, and at determining facilitators and barriers of the PWD's social integration.

Dementia Care Research and Psychosocial Factors.

Background: Recognizing Alzheimer's disease (AD) early is essential for enhancing patient outcomes. Therefore this research focused on exploring indicators of AD by investigating the role of declining financial capacity (FC) in predicting objetive cognitive impairment (OCI).

Method: We analyzed participants without OCI in Mini-mental state examination (MMSE, Table 1) or Clinical Dementia Rating-Sum of Boxes (CDR-SB, Table 2) scores from the ADNI database.

Dementia Care Research and Psychosocial Factors.

Background: Several studies have shown that financial capacity constitutes a vital component of instrumental activities of daily living. However, there is insufficient research investigating the relationship between financial impairment, brain volume changes and cognitive decline in Alzheimer's disease (AD). Here, we examine the association between brain volume changes and financial capacity in cognitively unimpaired (CU) and mild cognitively impaired (MCI) individuals.

Dementia Care Research and Psychosocial Factors.

Background: Although primary progressive aphasia (PPA) is considered a rarer form of dementia, individuals living with PPA are increasingly identified by healthcare professionals. Research investigating speech-language assessment and intervention in PPA has been conducted primarily in monolingual speakers and little is known about clinical decision-making of speech-language pathologists (SLPs) working with bilinguals with PPA.

Methods: A comprehensive survey containing questions regarding clinician confidence, prioritization, and ratings of basic competency for Volkmer, Cartwright, Ruggero et al.

Activation and Reactivity of the Deubiquitinylase OTU Cezanne-2 from MD Simulations and QM/MM Calculations.

Cezanne-2 (Cez2) is a deubiquitinylating (DUB) enzyme involved in the regulation of ubiquitin-driven cellular signaling and selectively targets Lys11-linked polyubiquitin chains. As a representative member of the ovarian tumor (OTU) subfamily DUBs, it performs cysteine proteolytic isopeptide bond cleavage; however, its exact catalytic mechanism is not yet resolved. In this work, we used different computational approaches to get molecular insights into the Cezanne-2 catalytic mechanism.

Dementia Care Research and Psychosocial Factors.

Background: Amyloid and tau pathologies are the hallmarks of Alzheimer's disease (AD). Previous research indicated notable connections between financial capacity and AD biomarkers. Here, we aimed to understand whether financial capacity is affected by the cerebral accumulation of tau and amyloid.

The Elusive Ternary Intermediates of Chiral Phosphoric Acids in Ion Pair Catalysis─Structures, Conformations, and Aggregation.

In ion-pair catalysis, the last intermediate structures prior to the stereoselective transition states are of special importance for predictive models due to the high isomerization barrier between - and -substrate double bonds connecting ground and transition state energies. However, in prior experimental investigations of chiral phosphoric acids (CPA) solely the early intermediates could be investigated while the key intermediate remained elusive. In this study, the first experimental structural and conformational insights into ternary complexes with CPAs are presented using a special combination of low temperature and relaxation optimized N HSQC-NOESY NMR spectroscopy to enhance sensitivity.

Dementia Care Practice.

Background: Value-based healthcare (VBHC) is a novel concept derived from economic research which is recently implemented in various medical departments and facilities. Additionally to an improvement of patient care, it postulates a reduction of expenses by providing patients with what they really need. Value in this context is defined as outcomes achieved for patients relative to the required costs.

Technology and Dementia Preconference.

Background: Familial Alzheimer's disease research necessitates innovative methodologies to disentangle the intricate relationships between genetic factors and neuroimaging measures. Traditional frequentist approaches, often hampered by small sample sizes in this population and challenges in incorporating prior knowledge transparently, may limit the robustness of findings.

Methods: We analyzed neuroimaging data of preclinical PSNE1 single mutation carriers, utilizing the software JASP to test effects of carrier status on measures of basal forebrain functional connectivity using both frequentist and Bayesian approach.

Technology and Dementia Preconference.

Background: Timely diagnosis of mild cognitive impairment (MCI) in Alzheimer's disease (AD) is crucial for early interventions, but its implementation is often challenging due to the complexity and time burden of required cognitive assessments. Remote unsupervised self-testing of cognition can potentially addres this health care challenge. We conducted the to date largest evaluation of feasibility and experienced added value of unsupervised digital remote assessment in primary and specialized health care in Germany.

Technology and Dementia Preconference.

Background: Alzheimer's Disease (AD) is associated with sleep disturbances. Moreover, individuals with sleep disturbances have been reported to have a higher risk for developing AD. The measurement of sleep behavior therefore opens the opportunity for a potential digital biomarker of AD.