An Icosahedral 55-Atom Iron Hydride Cluster Protected by Tri--butylphosphines.

Nanoclusters are nanometer-sized molecular compounds characterized by significant metal-metal bonding and low average oxidation states, and they exhibit unique properties distinct from those of small metal complexes or nanoparticles. Unlike noble metals stable in metallic forms, the synthesis of nanometer-sized iron clusters has been precluded by the relatively weak iron-iron bonds and the high reactivity of low oxidation state iron, despite the extensive history of molecular iron compounds. Here, we report the synthesis and characterization of a cationic 55-atom iron cluster with a 1.

Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex.

Communication sound processing in mouse AC is lateralized. Both left and right AC are highly specialised and differ in auditory stimulus representation, functional connectivity and field topography. Previous studies have highlighted intracortical functional circuits that explain hemispheric stimulus preference.

Increased serum NfL and GFAP levels indicate different subtypes of neurologic immune-related adverse events during treatment with immune checkpoint inhibitors.

Neurologic immune-related adverse events (nirAEs) represent rare, yet severe side effects associated with immune checkpoint inhibitor (ICI) therapy. Given the absence of established diagnostic biomarkers for nirAEs, we aimed to evaluate the diagnostic utility of serum Neurofilament Light Chain (NfL) and Glial Fibrillary Acidic Protein (GFAP). Fifty-three patients were included at three comprehensive cancer centers, of these 20 patients with manifest nirAEs and 11 patients with irHypophysitis.

Go big or spin fast? Biomechanical deterministic models for snowboard freestyle tricks performed on a trampoline.

In snowboard freestyle, rotation is the key indicator of trick difficulty, encouraging riders to perform tricks with more rotation. In many cases, snowboarders learn and practice tricks using training tools such as trampolins and/or landingbags before they transfer this tricks on-snow. It has not yet been scientifically investigated which movement parameters are primarily responsible for the acquisistion of increasingly difficult cork tricks.

RNase P cleavage of pseudoknot substrates reveals differences in active site architecture that depend on residue N-1 in the 5' leader.

We show that a small biotin-binding RNA aptamer that folds into a pseudoknot structure acts as a substrate for bacterial RNase P RNA (RPR) with and without the RNase P C5 protein. Cleavage in the single-stranded region in loop 1 was shown to depend on the presence of a RCCA-motif at the 3' end of the substrate. The nucleobase and the 2'hydroxyl at the position immediately 5' of the cleavage site contribute to both cleavage efficiency and site selection, where C at this position induces significant cleavage at an alternative site, one base upstream of the main cleavage site.

Antimicrobial Polymer via ROMP of a Bioderived Tricyclic Oxanorbornene Lactam Derivative.

The rapid emergence of multidrug-resistant (MDR) bacteria represents a critical global health threat, underscoring the urgent need for alternative antimicrobial strategies beyond conventional antibiotics. In this study, we report the synthesis of novel biobased antimicrobial polymers bearing quaternary ammonium salts, derived from sustainable feedstocks, maleic anhydride, dimethylaminobenzaldehyde, and furfurylamine. The functional tricyclic oxanorbornene lactam monomer is polymerized via ring opening metathesis polymerization, yielding well-defined polymers with controlled molar masses and low dispersity.

Evaluation of Real-Time Cardiovascular Flow MRI Using Compressed Sensing in a Phantom and in Patients With Valvular Disease or Arrhythmia.

Background: Real-time (RT) phase contrast (PC) flow MRI can potentially be used to measure blood flow in arrhythmic patients. Undersampled RT PC has been combined with online compressed sensing (CS) reconstruction (CS RT) enabling clinical use. However, CS RT flow has not been validated in a clinical setting.

Exploring Environmental Microfungal Diversity Through Serial Single Cell Screening.

Known for its remarkable diversity and ecological importance, the fungal kingdom remains largely unexplored. In fact, the number of unknown and undescribed fungi is predicted to exceed the number of known fungal species by far. Despite efforts to uncover these dark fungal taxa, we still face inherent sampling biases and methodological limitations.

Treating episodic migraine with precision: the evolving landscape of targeted therapies driven by insights in disease biology.

Introduction: Migraine is a disabling neurological disorder with a complex neurobiology. It appears as a cyclic disorder of sensory processing, affecting multiple systems beyond nociception. Overlapping mechanisms, including dysfunctional processing of sensory input from brain structures are involved in the generation of attacks.

Carborane-decorated siloles with highly efficient solid-state emissions - what drives the photophysical properties?

New hybrids were synthesised by linking carboranes and siloles, both of which are known as aggregation-induced emission active units. Although most of the newly synthesised systems do not display notable quantum yield either in solution or in the aggregated state, they emit strongly in the solid-state, and a quantum yield of up to 100% can be achieved. The tailorable quantum yield can be attributed to the packing of the molecules in the crystal lattice ruled by the carborane and phenyl moieties according to the SC-XRD data.

Departing from standard practices: Strategic application of value engineering in the anatomy laboratory to enhance formaldehyde extraction using high-impact, low-cost, and low-maintenance solutions.

This study describes the process of developing a high-impact, low-cost, and low-maintenance air ventilation system for anatomy facilities. It employed the strategic application of Value Engineering (VE), assuring that the air ventilation system meets contemporary threshold limit values (TLVs) for formaldehyde in the working zone of dissection tables. A creative-innovative construction methodology was used, combining the Theory of Inventive Problem Solving (TRIZ/TIPS) and VE for an anatomy laboratory air ventilation concept.

Photoinduced formation of a platina-α-lactone - a carbon dioxide complex of platinum. Insights from femtosecond mid-infrared spectroscopy.

The binding of carbon dioxide to a transition metal is a complex phenomenon that involves a major redistribution of electron density between the metal center and the triatomic ligand. The chemical reduction of the ligand reveals itself unambiguously by an angular distortion of the CO-molecule as a result of the occupation of an anti-bonding π-orbital and a shift of its antisymmetric stretching vibration, ν, to lower wavenumbers. Here, we generate a carbon dioxide complex of the heavier group-10 metal, platinum, by ultrafast electronic excitation and cleavage of CO from the photolabile oxalate precursor, oxaliplatin, and monitored the ensuing primary dynamics with ultrafast mid-infrared spectroscopy.

Living in Biological Darkness II: Impact of Winter Habitual Daytime Light on Night-Time Sleep.

Timing and architecture of sleep are co-driven by circadian rhythms modulated by their major Zeitgeber light and darkness. In a natural environment, one is exposed to 3.000 lx (cloudy winter sky) to 100.

Leveraging N- substituents to tune the donor/acceptor properties of mesoionic imines (MIIs).

In this work, we show two synthetic routes to substitute the N position of mesoionic imines (MIIs). By Buchwald-Hartwig amination, 5-amino-1,2,3-triazoles can be arylated at the said position, showing the versatility of amino-triazoles as building blocks for MIIs. The reaction of MIIs with electrophiles (MeI, fluoro-arenes) highlights the nucleophilic nature of MIIs as even at room temperature aromatic C-F bonds can be activated with MIIs.

Two complementing selection systems based on cca-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases.

tRNA nucleotidyltransferase represents a ubiquitous and essential activity that adds the indispensable CCA triplet to the 3'-end of tRNAs. To fulfill this function, the enzyme contains a set of highly conserved motifs whose coordinated interplay is crucial for the sequence-specific CCA polymerization. In the human enzyme, alterations within these regions have been shown to lead to the manifestation of disease.

Photogenerated charge carrier dynamics on Pt-loaded SrTiO nanoparticles studied transient-absorption spectroscopy.

Loading cocatalysts on semiconductor-based photocatalysts to create active reaction sites is a preferable method to enhance photocatalytic activity and a widely adopted strategy to achieve effective photocatalytic applications. Although theoretical calculations suggest that the broad density of states of noble metal cocatalysts, such as Pt, act as a recombination center, this has never been experimentally demonstrated. Herein, we employed pico-nano and nano-micro second transient absorption spectroscopy to investigate the often overlooked photogenerated holes, instead of the widely studied electrons on Pt- and Ni-loaded SrTiO to evaluate the effects of cocatalysts as a recombination center.

Identification of novel triazolylquinoxaline-based metal complexes supported by experimental and virtual screenings.

The formation of novel complexes from so far non-investigated ligands and different metal centers is important for the development of new functional materials such as (photo)catalysts or biologically active compounds. Still, promising strategies to quickly and systematically investigate the complexation behavior of selected ligands are rare. We developed an NMR-based screening approach to monitor changes within reaction mixtures containing metals and ligands on a small scale a simple but reliable protocol.

Analysis of the Biomechanical Effects of Vertebral Body Tethering with Apical Fusion.

Study Design: Biomechanical study by using a multi-body simulation approach.

Objective: Objectification of spinal biomechanics after Vertebral Body Tethering with and without Apical Fusion.

Summary Of Background Data: Vertebral body tethering, a motion preserving surgical technique for correction of adolescent idiopathic scoliosis, is increasingly being used for thoracolumbar curves.

Semantic search helper: A tool based on the use of embeddings in multi-item questionnaires as a harmonization opportunity for merging large datasets - A feasibility study.

Background: Recent advances in natural language processing (NLP), particularly in language processing methods, have opened new avenues in semantic data analysis. A promising application of NLP is data harmonization in questionnaire-based cohort studies, where it can be used as an additional method, specifically when only different instruments are available for one construct as well as for the evaluation of potentially new construct-constellations. The present article therefore explores embedding models' potential to detect opportunities for semantic harmonization.

Establishment of an Agrobacterium-mediated transformation system for the genetic engineering of Linum grandiflorum Desf.

Genetic transformation is a powerful tool in plant biotechnology. However, its application is limited to species that are well-studied and easy to transform. There is a critical need to establish transformation protocols for non-model species.

Validity and Accuracy of the Derived Left Ventricular End-Diastolic Pressure in Impella 5.5.

Background: Consensus regarding on-support evaluation and weaning concepts from Impella 5.5 support is scarce. The derived left ventricular end-diastolic pressure (dLVEDP), estimated by device algorithms, is a rarely reported tool for monitoring the weaning process.

Informed circular fields: a global reactive obstacle avoidance framework for robotic manipulators.

In this paper, we present a global reactive motion planning framework designed for robotic manipulators navigating in complex dynamic environments. Utilizing local minima-free circular fields, our methodology generates reactive control commands while also leveraging global environmental information from arbitrary configuration space motion planners to identify promising trajectories around obstacles. Furthermore, we extend the virtual agents framework introduced in Becker et al.