Distribution, Phytochemical Insights, and Cytotoxic Potential of the Genus: A Comprehensive Review of , , and .

This review evaluates the cytotoxic potential of the genus, with a focus on , , and . These species, known for their diverse phytochemical compositions, exhibit notable cytotoxic effects that suggest their utility in natural cancer treatments. Compounds such as quercetin, kaempferol, and sesbagrandiforian A and B have been highlighted for their strong antioxidant and antiproliferative effects, further emphasizing their therapeutic potential.

Nanoparticle innovations in targeted cancer therapy: advancements in antibody-drug conjugates.

Antibody-drug conjugates (ADCs) have emerged as a promising strategy in targeted cancer therapy, enabling the precise delivery of cytotoxic agents to tumor sites while minimizing systemic toxicity. However, traditional ADCs face significant limitations, including restricted drug loading capacity, where an optimal drug-to-antibody ratio (DAR) is crucial; low DARs may lead to insufficient potency, while high DARs can cause rapid clearance and increased toxicity. Additionally, ADCs often suffer from instability in circulation due to the potential for premature release of cytotoxic agents, resulting in off-target effects and reduced therapeutic efficacy.

Investigating macro marine litter and beach cleanliness along Southern Vietnam beaches.

Plastic contamination is a major issue for marine ecosystems, with macro-litter posing a growing threat globally. This study assesses macro-marine litter on Vung Tau beaches, Southern Vietnam, providing baseline data for marine litter pollution and identifying critical action plans for plastic control. Survey results showed litter density ranging from 0.

Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics.

Extracellular vesicles (EVs) are emerging as viable tools in cancer treatment due to their ability to carry a wide range of theranostic activities. This review summarizes different forms of EVs such as exosomes, microvesicles, apoptotic bodies, and oncosomes. It also sheds the light onto isolation methodologies, characterization techniques and therapeutic applications of all discussed EVs.

Adoptive NK cell therapy in AML: progress and challenges.

Adoptive cell therapy (ACT) using natural killer (NK) cells has emerged as a promising therapeutic strategy for acute myeloid leukemia (AML), addressing challenges such as chemotherapy resistance and high relapse rates. Over the years, clinical trials and studies have explored various sources of NK cells, including ex vivo expanded NK cell lines, CAR-NK cells, peripheral blood-derived NK cells, and umbilical cord blood-derived NK cells. These therapies have demonstrated varying degrees of therapeutic efficacy, ranging from transient anti-leukemia activity to sustained remission in select patient groups.

Studying the effect of processing parameters on the microstructure, strength, hardness, and corrosion characteristics of friction stir dissimilar welded AA5083 and AA7075 aluminum alloys reinforced with Al-SiC matrix.

The complementary properties of corrosion resistance and ballistic resistance of AA5083 and AA7075, respectively, explain the significance of welding these two alloys in the marine armor industry. This study investigates a novel Al-SiC matrix reinforcement with a different SiC weight ratio in dissimilar friction stir welding of the AA5083/AA7075 joint at different transverse and rotational speeds. The study deduced that the novel matrix can play an important role in improving strength and ductility simultaneously.

Exploring cigarette butts pollution in Vung Tau beaches: A case study in Vietnam.

Cigarette butts (CBs), alongside other plastic items, are widely recognized as a significant source of marine litter in coastal areas worldwide. This research is the first to examine CB pollution, offering valuable insights into its impact across various beaches in Vung Tau, Vietnam. A total of 512 CBs were collected, with an average density of 0.

Comparative metabolomic study of twelve Acacia species by UHPLC-q-tof-ESI-MS coupled with chemometrics in correlation with antibacterial activity.

Genus Acacia comprises around 1500 species. They are widely used to treat inflammation as well as bacterial and fungal infections as they are enriched in phytochemicals, especially phenolics. The aim of this study was to evaluate the antibacterial activity of leaves' methanolic extracts of twelve Acacia species growing in Egypt against Vibrio parahaemolyticus, Salmonella enterica, Listeria monocytogens, Klebsiella pnemoniae, Bacillus aquimaris, Bacillus subtilis, and Escherichia coli.

Investigation of alpha-glucosidase inhibition activity of Artabotrys sumatranus leaf extract using metabolomics, machine learning and molecular docking analysis.

One way to treat diabetes mellitus type II is by using α-glucosidase inhibitor, that will slow down the postprandial glucose intake. Metabolomics analysis of Artabotrys sumatranus leaf extract was used in this research to predict the active compounds as α-glucosidase inhibitors from this extract. Both multivariate statistical analysis and machine learning approaches were used to improve the confidence of the predictions.

Microscale Audits of the Built Environment and the Challenges for Pedestrians in 4 Residential Areas in Oman.

Background: Ensuring a livable and healthy built environment that addresses challenges of climate change and the pandemic of noncommunicable diseases should include creating an environment support of physical activity. This study aims to build local evidence on improving the residential areas by assessing the built environment of 4 residential areas in Oman.

Methods: This study uses the Microscale Audit of Pedestrian Streetscapes-Mini, a 15-item tool with 4 subscales (destinations and land use, aesthetics, pedestrian infrastructure, and crossings/traffic safety), to conduct environmental audits of 4 areas in Barka and Nizwa, Oman.

Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases.

The intersection of electromagnetic radiation and neuronal communication, focusing on the potential role of biophoton emission in brain function and neurodegenerative diseases is an emerging research area. Traditionally, it is believed that neurons encode and communicate information via electrochemical impulses, generating electromagnetic fields detectable by EEG and MEG. Recent discoveries indicate that neurons may also emit biophotons, suggesting an additional communication channel alongside the regular synaptic interactions.

Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast.

Chronological lifespan (CLS) in budding yeast Saccharomyces cerevisiae, which is defined as the time nondividing cells in saturation remain viable, has been utilized as a model to study post-mitotic aging in mammalian cells. CLS is closely related to entry into and maintenance of a quiescent state. Many rearrangements that direct the quiescent state enhance the ability of cells to endure several types of stress.

Diosmin and Coenzyme q10: Synergistic histopathological and functional protection against doxorubicin-induced hepatorenal injury in rats.

Doxorubicin (DOX) is a cytotoxic anthracycline used to treat a variety of cancers. Cardiotoxicity, hepatotoxicity, and nephrotoxicity are adverse effects of DOX, that limit prognosis. The study aims to determine if diosmin (DIOS) and coenzyme Q10 (CoQ10) alone or in combination protect rats against DOX-induced liver and kidney damage.

Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition - a randomized controlled trial.

Fatigue is the most prevalent symptom within the post-COVID condition (PCC). Furthermore, many patients suffer from decreased physical performance capacity and post-exertional malaise. Although exercise has been proposed as an effective therapeutic strategy for PCC, there is limited evidence on individualised and symptom-titrated exercise interventions in patients with fatigue and PEM.

Insights into the human cDNA: A descriptive study using library screening in yeast.

The utilization of human cDNA libraries in yeast genetic screens is an approach that has been used to identify novel gene functions and/or genetic and physical interaction partners through forward genetics using yeast two-hybrid (Y2H) and classical cDNA library screens. Here, we summarize several challenges that have been observed during the implementation of human cDNA library screens in Saccharomyces cerevisiae (budding yeast). Upon the utilization of DNA repair deficient-yeast strains to identify novel genes that rescue the toxic effect of DNA-damage inducing drugs, we have observed a wide range of transcripts that could rescue the strains.

Systematic Investigations of the Solid Solution Zr(VAl) Adopting the Laves Phase Structures.

Laves phases are an interesting field of research when it comes to structural chemistry and physical properties. Investigations of the ternary system Zr-V-Al showed, in contrast to the system Hf-V-Al, that no superstructures can be observed within the solid solution Zr(VAl) High values of x form aluminum rich phases that adopt the hexagonal MgZn type structure while low values of x lead to vanadium rich phases that adopt the cubic MgCu type. All samples were investigated by powder X-ray diffraction experiments.

Identification of deleterious non-synonymous single nucleotide polymorphisms in the mRNA decay activator ZFP36L2.

More than 4,000 single nucleotide polymorphisms (SNP) variants have been identified in the human gene, however only a few have been studied in the context of protein function. The tandem zinc finger domain of ZFP36L2, an RNA binding protein, is the functional domain that binds to its target mRNAs. This protein/RNA interaction triggers mRNA degradation, controlling gene expression.

Exploring sperm cell motion dynamics: Insights from genetic algorithm-based analysis.

Accurate analysis of sperm cell flagellar dynamics plays a crucial role in understanding sperm motility as flagella parameters determine cell behavior in the spatiotemporal domain. In this study, we introduce a novel approach by harnessing Genetic Algorithms (GA) to analyze sperm flagellar motion characteristics and compare the results with the traditional decomposition method based on Fourier analysis. Our analysis focuses on extracting key parameters of the equation approximating flagellar shape, including beating period time, bending amplitude, mean curvature, and wavelength.

Magnetic control of soft microrobots near step-out frequency: Characterization and analysis.

Magnetically actuated soft microrobots hold promise for biomedical applications that necessitate precise control and adaptability in complex environments. These microrobots can be accurately steered below their step-out frequencies where they exhibit synchronized motion with external magnetic fields. However, the step-out frequencies of soft microrobots have not been investigated yet, as opposed to their rigid counterparts.

Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen.

Drug conjugates of tamoxifen and melatonin linked through the amide side chain of melatonin (,) were reported as promising agents for future treatment of breast cancer, possibly reversing the adverse effects of tamoxifen. Here, we report the synthesis and pharmacological evaluation of a novel series of anticancer drug conjugates linking melatonin with tamoxifen through polymethylene spacers through the ether oxygen of melatonin (-, -, ) and compare them to the previously reported amide-linked analogues and . All hybrid ligands are antagonists of estrogen receptor alpha and agonists of the melatonin MT receptor with variable potencies.

Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer.

Gasotransmitters play crucial roles in regulating many physiological processes, including cell signaling, cellular proliferation, angiogenesis, mitochondrial function, antioxidant production, nervous system functions and immune responses. Hydrogen sulfide (HS) is the most recently identified gasotransmitter, which is characterized by its biphasic behavior. At low concentrations, HS promotes cellular bioenergetics, whereas at high concentrations, it can exert cytotoxic effects.

Direct and indirect modulation of STAT3/CSE/HS axis in triple negative breast cancer by non-coding RNAs: MALAT-1 lncRNA, miR-486-5p and miR-30a-5p.

Recently, our research group reported an upregulated expression profile of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), key enzymes involved in hydrogen sulfide (HS) production, in triple-negative breast cancer (TNBC) patients. However, the regulatory mechanisms underlying such altered expression patterns are not yet fully understood. In this study, we focused on the role of the STAT3/CSE/HS axis and the potential involvement of non-coding RNAs (ncRNAs), including long and short ncRNAs, in modulating this pivotal pathway.