EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents.

Introduction: The identification of type 1 diabetes at an early presymptomatic stage has clinical benefits. These include a reduced risk of diabetic ketoacidosis (DKA) at the clinical manifestation of the disease and a significant reduction in clinical symptoms. The European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) represents a pioneering effort to advance early detection of type 1 diabetes through public health screening.

Sex-dependent modulation of T and NK cells and gut microbiome by low sodium diet in patients with primary aldosteronism.

Background: High dietary sodium intake is a major cardiovascular risk factor and adversely affects blood pressure control. Patients with primary aldosteronism (PA) are at increased cardiovascular risk, even after medical treatment, and high dietary sodium intake is common in these patients. Here, we analyze the impact of a moderate dietary sodium restriction on microbiome composition and immunophenotype in patients with PA.

Impact of climate change, biodiversity loss, and pollution on the incidence and manifestation of depressive and anxiety disorders.

Purpose Of Review: Climate change, biodiversity loss, and pollution present a major threat to health. Although emphasis has been put on physical health impacts, evidence on the mental health consequences is now also accumulating quickly. Given the rapid developments in the field, this article provides an expert opinion on the emerging research.

Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization.

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNALP) is essential for the immortalization of naive B lymphocytes (NBLs). However, the mechanisms remain elusive. To understand EBNALP's role in B-cell transformation, we compare NBLs infected with wild-type EBV and an EBNALP-null mutant EBV using multi-omics techniques.

Targeting pleuro-alveolar junctions reverses lung fibrosis in mice.

Lung fibrosis development utilizes alveolar macrophages, with mechanisms that are incompletely understood. Here, we fate map connective tissue during mouse lung fibrosis and observe disassembly and transfer of connective tissue macromolecules from pleuro-alveolar junctions (PAJs) into deep lung tissue, to activate fibroblasts and fibrosis. Disassembly and transfer of PAJ macromolecules into deep lung tissue occurs by alveolar macrophages, activating cysteine-type proteolysis on pleural mesothelium.

The giant genome of lily provides insights into the hybridization of cultivated lilies.

Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts. Here, we present reference genomes for Lilium sargentiae (lily, 35.

The snow must go on: how German cross-country skiers maintained training and performance in the face of COVID-19 lockdowns.

Background: The Covid-19 pandemic in 2020 led to disruption of sporting events, with athletes obliged to comply with national lockdown restrictions.

Purpose: To investigate the effect of the Covid-19 pandemic restrictions on national-team XC skiers' annual and weekly training distribution from training diaries, results from submaximal and maximal physiological roller ski tests, and competition results from the International Ski and Snowboard Federation (FIS) world cup.

Methods: Annual and weekly training type (specific, non-specific, strength, other) and intensity distribution (TID) data were collected for 12 German XC-skiers (Tier 4/5; BM: 67 ± 7 kg; age 26 ± 3 years; 6♀: V̇O 61.

Translation and validation of the Nature Relatedness Scale to German.

Over the recent past, tools have been developed to asses people's connection to and attitudes towards nature due to increasing interest in this topic in society and research. We translated one such questionnaire, the Nature Relatedness Scale, consisting of three subscales (NR-Self, NR-Perspective, NR-Experience) to German. We collected 251 data sets and performed a confirmatory factor analysis, followed by an exploratory factor analysis.

Diversity and functional traits based indigenous rhizosphere associated phosphate solubilizing bacteria for sustainable production of rice.

Introduction: Rice, particularly Basmati rice, holds significant global importance as a staple food. The indiscriminate use of phosphate-based fertilizers during rice production has led to high residual levels of these chemicals in soil, impacting soil health and fertility. This study aimed to address this challenge by investigating the potential of phosphate solubilizing bacteria (PSB) in improving soil fertility and boosting the growth of Basmati rice.

Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction.

Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.

Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.

The compact line-focus X-ray tube for microbeam radiation therapy - Focal spot characterisation and collimator design.

Purpose: Microbeam radiation therapy (MRT) has shown superior healthy tissue sparing at equal tumour control probabilities compared to conventional radiation therapy in many preclinical studies. The limitation to preclinical research arises from a lack of suitable radiation sources for clinical application of MRT due to high demands on beam quality. To overcome these limitations, we developed and built the first prototype of a line-focus X-ray tube (LFXT).

A TAF11 variant contributes to non-syndromic cleft lip only through modulating neural crest cell migration.

The NC_000006.12: g.34887814C>G variant in TAF11 was identified as a potential functional variant in a Chinese pedigree including two non-syndromic cleft lip only (NSCLO) cases.

The association between different timeframes of air pollution exposure and COVID-19 incidence, morbidity and mortality in German counties in 2020.

Background: Ambient air pollution is a known risk factor for several chronic health conditions, including pulmonary dysfunction. In recent years, studies have shown a positive association between exposure to air pollutants and the incidence, morbidity, and mortality of a COVID-19 infection, however the time period for which air pollution exposure is most relevant for the COVID-19 outcome is still not defined. The aim of this study was to analyze the difference in association when varying the time period of air pollution exposure considered on COVID-19 infection within the same cohort during the first wave of the pandemic in 2020.

An overview of climate changes and its effects on health - from mechanisms to One Health.

Human activities, primarily the burning of fossil fuels, widespread deforestation, soil erosion or machine-intensive farming methods, manufacturing, food processing, mining, and construction iron, cement, steel, and chemicals industry, have been the main drivers of the observed increase in Earth's average surface temperature and climate change. Rising global temperatures, extreme weather events, ecosystems disruption, agricultural impacts, water scarcity, problems in access to good quality water, food and housing, and profound environmental disruptions such as biodiversity loss and extreme pollution are expected to steeply increase the prevalence and severity of acute and chronic diseases. Its long-term effects cannot be adequately predicted or mitigated without a comprehensive understanding of the adaptive ecosystems.

Earth's most needed uncultivated aquatic prokaryotes.

Aquatic ecosystems house a significant fraction of Earth's biosphere, yet most prokaryotes inhabiting these environments remain uncultivated. While recently developed genome-resolved metagenomics and single-cell genomics techniques have underscored the immense genetic breadth and metabolic potential residing in uncultivated Bacteria and Archaea, cultivation of these microorganisms is required to study their physiology via genetic systems, confirm predicted biochemical pathways, exploit biotechnological potential, and accurately appraise nutrient turnover. Over the past two decades, the limitations of culture-independent investigations highlighted the importance of cultivation in bridging this vast knowledge gap.

Exposure Profiles for the Long-Term Use of Disinfectants and Cleaning Products and Asthma.

Background: Using disinfectants and cleaning products (DCPs) at home and work is known to influence both the onset and course of asthma, but most epidemiological studies did not consider the multiplicity and correlations of exposures to DCPs. We aimed to identify exposure profiles for the long-term weekly use of DCPs by latent class analysis (LCA) and assess their associations with asthma.

Methods: LCA was conducted on data from 1143 young adults initially recruited in the German centers of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and followed up three times.

Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study.

Background: Little is known about the association between air pollution and self-perceived health (including both health-related quality of life [HRQoL] and self-rated health [SRH]). The aim of this study was therefore to explore whether long-term air pollution exposure is associated with worse self-perceived health, as measured by different tools.

Methods: We used a land-use regression model to determine the annual average levels of particulate matter with a diameter <10 μm (PM), coarse particles (PM), fine particles (PM), fine particle absorbances (PM), particle number concentration (PNC), ozone (O), nitrogen dioxide (NO), and nitrogen oxide (NO) for geocoded residential addresses (2014-2015).

Ecologically sustainable benchmarking of AI models for histopathology.

Deep learning (DL) holds great promise to improve medical diagnostics, including pathology. Current DL research mainly focuses on performance. DL implementation potentially leads to environmental consequences but approaches for assessment of both performance and carbon footprint are missing.

Novel flame retardants (NFRs) in e-waste: Environmental burdens, health implications, and recommendations for safety assessment and sustainable management.

Novel flame retardants (NFRs) have emerged as chemicals of environmental health concern due to their widespread use as an alternative to polybrominated diphenyl ethers (PBDE) in electrical and electronic devices. Humans and ecosystems are under threat because of e-waste recycling procedures that may emit NFRs and other anthropogenic chemicals into the e-waste workplace and the surrounding environment. The individual toxicity of NFRs including novel brominated flame retardants (NBFRs), their combined effects and the underlying mechanisms of toxicity have remained poorly understood.

Harnessing multimodal approaches for depression detection using large language models and facial expressions.

Detecting depression is a critical component of mental health diagnosis, and accurate assessment is essential for effective treatment. This study introduces a novel, fully automated approach to predicting depression severity using the E-DAIC dataset. We employ Large Language Models (LLMs) to extract depression-related indicators from interview transcripts, utilizing the Patient Health Questionnaire-8 (PHQ-8) score to train the prediction model.

Paternal impact on the developmental programming of sexual dimorphism.

Sexual dimorphism involves distinct anatomical, physiological, behavioral, and developmental differences between males and females of the same species, influenced by factors prior to conception and during early development. These sex-specific traits contribute to varied phenotypes and individual disease risks within and across generations and understanding them is essential in mammalian studies. Hormones, sex chromosomes, and imprinted genes drive this dimorphism, with over half of quantitative traits in wildtype mice showing sex-based variation.