2 results match your criteria: "German Institute of Human Nutrition Potsdam-Rebruecke[Affiliation]"

The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.

Diabetologia

October 2015

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rebruecke, Arthur-Scheunert-Allee 114-116, D-14558, Nuthetal, Germany.

Aims/hypothesis: Zfp69 was previously identified by positional cloning as a candidate gene for obesity-associated diabetes. C57BL/6J and New Zealand obese (NZO) mice carry a loss-of-function mutation due to the integration of a retrotransposon. On the NZO background, the Zfp69 locus caused severe hyperglycaemia and loss of beta cells.

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Background: Sub-Saharan Africa is facing a double burden of malnutrition: vitamin A deficiency (VAD) prevails, whereas the nutrition-related chronic conditions type 2 diabetes (T2D) and hypertension are emerging. Serum retinol—a VAD marker—increases in kidney disease and decreases in inflammation, which can partly be attributed to alterations in the vitamin A-transport proteins retinol-binding protein 4 (RBP4) and prealbumin. Kidney dysfunction and inflammation commonly accompany T2D and hypertension.

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