Efficacy of exercise training in SCT patients--who benefits most?

Patients undergoing allo-HCT often experience a substantial loss in physical performance. We have recently published the general effectiveness of an exercise intervention in 105 allo-HCT patients on physical performance and psychosocial well-being. However, predictor variables for differentiated treatment response remained unclear.

Initial insulin therapy in children and adolescents with type 1 diabetes mellitus.

Objective: The aim of the study was to define parameters that influence the initial insulin dosage in young subjects with type 1 diabetes regarding the amount of daily insulin, the ratios of basal and prandial insulin, and the insulin/carbohydrate ratios.

Study Design: We used a computer-based registry (with prospectively collected data) in Germany and Austria, a software for the management and data documentation of diabetic patients (DPV), to analyze the initial insulin therapy in 2247 children with newly diagnosed type 1 diabetes to identify factors that influence diabetes therapy within the first 10 d.

Results: For both genders, glucosylated hemoglobin A1c (HbA1c), blood pH at diabetes onset, and pubertal status are the major factors determining the initial insulin dosage calculated as the amount of daily insulin per kilogram body weight (kg), the basal and prandial insulin dose per kilogram, and day and the insulin/carbohydrate ratios for meals.

Combining short stent implantation and drug-eluting stenting for routine use yields a low restenosis rate.

Background: The feasibility of using a single short bare metal stent (BMS) (less than 9 mm) in a high proportion of coronary artery lesions was shown in a previous study, which reported a low rate of restenosis. The present study aimed to investigate immediate and long-term results of a procedure that uses a single short BMS for all lesions that can be successfully treated with this method, and an implantation of a drug-eluting stent (DES) for all other lesions.

Methods: In a series of 200 consecutive patients, 236 coronary artery lesions were treated with either a short BMS (168 of 236 [71.

Combining short stent implantation and drug-eluting stenting for routine use yields a low restenosis rate.

Background: Stent length serves as a predictor of restenosis in use of bare metal stents (BMS). This has been demonstrated in a feasibility study that used a single short BMS implant (<9 mm) in a high proportion of lesions; the study observed a low rate of restenosis.

Methods: We performed a pilot prospective study to investigate in a series of consecutive patients the immediate and long-term effects of implantation of either 1) a single short BMS for all lesions with low probability of restenosis or 2) a drug-eluting stent (DES) for all other lesions.

Angiographic outcome in multivessel disease (GABI II study) using new coronary device interventions and comparison with GABI I trial results.

Percutaneous coronary interventions using stents were investigated in patients with multivessel disease. Acute and long-term results were compared with those of the German Angioplasty Bypass Surgery Investigation trial in a prospective multicenter study. The study included 134 patients in whom 277 lesions were treated.