1 results match your criteria: "German Center for Neurologic Diseases[Affiliation]"
Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD.
Front Neurosci
April 2019
Department of Neurology, University Hospital Bonn, German Center for Neurologic Diseases, Bonn, Germany.
Article Synopsis
- Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer's, and its causes are still largely unknown, particularly the role of epigenetics in its development.
- Current research is utilizing patient-specific stem cell-derived neurons to create human disease models that facilitate the study of epigenetic changes, such as DNA methylation and microRNA patterns in PD.
- While these human neuronal models show promise for understanding epigenetic alterations, further research is needed to establish their suitability and assess their limitations compared to native human neurons.