5 results match your criteria: "German Center for Lung Research (DZL)Heidelberg[Affiliation]"
Air travel in patients suffering from pulmonary hypertension-A prospective, multicentre study.
Pulm Circ
July 2024
Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany.
The PEGASUS study is the first multicentric and prospective assessment of the safety of air travel flying in pulmonary hypertension (PH) (NCT03051763). Data of air travel from 60 patients with PH was available. No severe adverse events occurred.
View Article and Find Full Text PDFValidation of the ALK-Brain Prognostic Index for patients with ALK-rearranged lung cancer and brain metastases.
ESMO Open
December 2023
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Thoracic Oncology Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden.
Background: Brain metastases (BMs) are a key challenge in the management of anaplastic lymphoma kinase-rearranged non-small-cell lung cancer (ALK+ NSCLC), but prognostic scores are complicated or rely on data before the era of tyrosine kinase inhibitors (TKIs). This study aimed to validate the novel ALK-Brain Prognostic Index (ALK-BPI), which was originally proposed based on 44 TKI-treated ALK+ NSCLC patients from Karolinska University Hospital, using an external clinical cohort.
Patients And Methods: TKI-treated ALK+ NSCLC patients with BM from Heidelberg (n = 82, cohort 1) were retrospectively analyzed alone and together with the original Karolinska cohort (n = 126, cohort 2).
Article Synopsis
- Iron deficiency is prevalent among patients with idiopathic and heritable pulmonary arterial hypertension (I/HPAH), with 84% needing iron supplementation.
- This study investigated the regulation of the iron hormone hepcidin in I/HPAH patients, focusing on those with and without pathogenic variants in the relevant gene, in comparison to healthy controls.
- Results showed hepcidin levels were similar across groups and indicated that iron regulation in I/HPAH patients is normal, with iron deficiency occurring independently of any genetic variants.
Clustering of Subgingival Microbiota Reveals Microbial Disease Ecotypes Associated with Clinical Stages of Periodontitis in a Cross-Sectional Study.
Front Microbiol
March 2017
Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital HeidelbergHeidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL)Heidelberg, Germany.
Periodontitis is characterized by chronic inflammation associated with alteration of the oral microbiota. In contrast to previous microbiome studies focusing on comparison between extreme phenotypes, our study analyzed a random sample of 85 people. The aim of this study was to link microbial differences to disease's prevalence and severity.
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