1 results match your criteria: "German Center for Diabetes Research (DZD). Electronic address: anne.eugster@crt-dresden.de.[Affiliation]"
Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells.
J Immunol Methods
December 2013
DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Germany; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD). Electronic address:
T cells have diversity in TCR, epitope recognition, and cytokine production, and can be used for immune monitoring. Furthermore, clonal expansion of TCR families in disease may provide opportunities for TCR-directed therapies. We developed methodology for sequencing expressed genes of TCR alpha and beta chains from single cells and applied this to vaccine (tetanus-toxoid)-responsive CD4(+) T cells.
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