2 results match your criteria: "Geriatrics Research Institute Hospital[Affiliation]"
Intern Med
January 2021
Dementia Center, Geriatrics Research Institute Hospital, Japan.
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder clinically characterized by slowly progressing spastic paraparesis. We herein report a 50-year-old Japanese woman who presented with slowly progressing spastic paraplegia and a history of Paget's disease of bone (PDB). Genetic testing revealed a mutation of the Valosin-containing protein (VCP) gene (p.
View Article and Find Full Text PDFJ Alzheimers Dis
October 2020
Department of Neurology, Geriatrics Research Institute Hospital, Maebashi, Aomori, Japan.
Amyloid-β (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD). Because AD pathologies begin two decades before the onset of dementia, prevention of Aβ amyloidosis has been proposed as a mean to block the pathological cascade. Here, we generate a transgenic plant-based vaccine, a soybean storage protein containing Aβ4-10, named Aβ+, for oral Aβ immunization.
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