Comparative effectiveness of delirium recognition with and without a clinical decision assessment system on outcomes of hospitalized older adults: Cluster randomized controlled trial.

Background: Early recognition of delirium is essential for effective management, but it often goes unrecognized, resulting in adverse outcomes. Clinical decision support systems can enhance adherence to guidelines and improve patient outcomes. We developed a mobile-based clinical decision assessment tool (3D-DST) based on the 3-minute diagnostic interview for confusion assessment method-defined delirium (3D-CAM).

Hck promotes IL-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the JAK-STAT3 signaling pathway.

We investigated role of haematopoietic cell kinase (Hck) in osteoarthritis (OA) and to explore the underlying mechanisms driving its effects. An OA animal model was established and after OA induction, rats received intra-articular injections of lentivirus twice a week for four weeks. Rats were divided into four groups: control (healthy rats without OA), OA model (rats with induced OA), OA + Len-si-NC (OA rats treated with a non-targeting control lentivirus), and OA + Len-si-Hck (OA rats treated with lentivirus targeting Hck).

Pattern of Uveitis in Northern Vietnam.

Purpose: To characterize the spectrum of uveitis in patients visiting three tertiary hospitals in Hanoi, Vietnam.

Methods: This study collected prospective and multicenter data from patients diagnosed with uveitis at three tertiary hospitals in Hanoi City, Vietnam, between January 2022 and January 2024. Data on age, sex, clinical and laboratory findings, and etiology were collected.

Mental health literacy and the public perception of persons with depression and schizophrenia in Vietnam.

Background: Vietnam's mental health care system is undergoing significant changes since the government has initiated large-scale programs to reform and develop the mental health care infrastructure. Cultural belief systems on mental illnesses influence help-seeking behavior and compliance. This study investigates the belief systems about people with schizophrenia and depression among people living in the Hanoi area.

[The level of thyroid stimulating hormones in different gender and age and the association with the risk of coronary heart disease in cohort population].

To analyze the thyroid stimulating hormone (TSH) levels in different genders and ages, and the association between TSH level and the risk of coronary heart disease. The baseline survey was conducted using a multi-stage cluster random sampling method from September to December 2015, in Jurong City, Jiangsu Province. A total of 10 703 participants were included in the analysis.

The impact of photodynamic therapy on cellular immune function in patients with cervical HPV infection.

Introduction: Cervical Human Papillomavirus (HPV) infection, a common sexually transmitted infection, can lead to cervical cancer. This study investigates the impact of Photodynamic Therapy (PDT) on cellular immune function in cervical HPV-infected patients.

Methods: From October 2022 to February 2023, 60 patients with cervical HPV infection were randomly assigned to a control group (conventional treatment) or a PDT group (PDT treatment), each with 30 patients.

Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage.

Background: The role of proximal tubular autophagy in repairing kidney injury following ischemia remains unclear.

Methods: In this study, we utilized mice with conditional deletion of the Atg5 gene in proximal tubules and monitored the long-term dynamic regulation of autophagy following ischemic acute kidney injury (AKI).

Results: The results showed that Atg5-deficient proximal tubule epithelial cells exhibited damaged mitochondria, concentric membranes, and lysosomal accumulation 24 h after ischemia/reperfusion.

USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway.

Objective: This study aimed to investigate the effect of Ubiquitin-Specific Peptidase 22 (USP22) on the inflammatory response mediated by BV-2 mouse microglia and explore the role of the PU box binding protein 1 (PU.1)/NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome in the USP22-induced polarization of BV-2 cells.

Methods: The BV-2 mouse microglia line was cultured in vitro, and plasmid and siRNA transfection was performed to overexpress or knockdown USP22.

Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study.

Background: Chronic obstructive pulmonary disease(COPD) hospitalization heightens risks for patients, including mortality, reduced quality of life, and financial strain. Walking pace (WP) and hand grip strength (HGS) are key indicators, their direct connection to COPD hospitalization is uncertain.

Objective: To investigate the relationship between genetic determinants of walking pace, hand grip strength, and the risk of COPD hospitalization as well as lung function.

Phase angle as a predictor of mortality in elderly patients with multimorbidity: a matched case-control study.

Background: We aimed to investigate the value of phase angle (PhA) as a prognostic marker for mortality in elderly patients with multimorbidity using a matched case-control study.

Methods: This study was conducted with patients 70 years of age or older with multimorbidity at Beijing Geriatric Hospital. The body composition parameters including PhA were determined using bioelectrical impedance analysis.

Identification of lipid metabolism-related biomarkers and prognostic analysis in geriatric patients with sepsis.

Introduction: This study aimed to find the lipid metabolism-associated biomarkers in geriatric patients with sepsis.

Methodology: The gene expression profiles of specimens from geriatric patients with sepsis were retrieved from the Gene Expression Omnibus database. Differentially expressed genes were obtained via "limma" R package, and modules and genes highly associated with geriatric patients with sepsis were screened via "WGCNA" R package.

Medical exposure to micro(nano)plastics: An exposure pathway with potentially significant harm to human health that should not be overlooked.

Micro(nano)plastics (MNPs) are an emerging type of contaminants that are widely present in the environments that people live in. MNPs can enter the human body in a variety of pathways, but the three main ones are through dietary intake, air inhalation, and skin contact. However, it has been discovered that medical plastics used in medical activities also pose potential risks to MNPs exposure as exposure pathways are continuously refined and clarified.

Effectiveness of multifaceted interventions including motivational interviewing and home-based rehabilitation program for improving mental and physical health in stroke patients: A randomized controlled trial.

Background: In Vietnam, early screening and intervention for post-stroke mental health are limited, with rising demand for home-based rehabilitation due to the scarcity of inpatient programs.

Objectives: We aimed to evaluate the effectiveness of multifaceted interventions, including Motivational Interviewing and home-based rehabilitation, in improving the mental and physical health of stroke patients.

Design: A randomized controlled trial at the Vietnam National Geriatric Hospital assessed a multi-intervention approach for stroke survivors from 2021 to 2022.

Association of metabolic score for insulin resistance with progression or regression of prediabetes: evidence from a multicenter Chinese medical examination cohort study.

Objective: Few studies have evaluated the changes in blood glucose status in individuals with prediabetes, and this study aimed to analyze the association between metabolic score for insulin resistance (MetS-IR) and the progression or regression of prediabetes.

Methods: This retrospective cohort study used research data from medical examination institutions under the Rich Healthcare Group in 32 regions across 11 cities in China. Progression of prediabetes to diabetes and regression to normal fasting glucose (NFG) were defined based on glycemic changes during follow-up.

Predictive Factors for Swallowing Function Decline in Older Adults With Alzheimer's Disease: A 1-Year Longitudinal Study.

Background: By 2060, the global burden of dementia, particularly Alzheimer's disease (AD), is expected to increase significantly, necessitating effective palliative care strategies. Dysphagia, a common condition among people with dementia, leads to malnutrition, aspiration pneumonia, and a reduced quality of life.

Objective: This study aimed to identify oral health management factors that could predict a decline in swallowing function in older adults with AD.

Ultrasound combined with DSA-guided pulsed radiofrequency for perineal herpes zoster pain management: clinical outcomes and complications.

Background: Herpes zoster (HZ) in the perineal area is a rare disease. There are limited treatment options for this disease. This study aimed to assess the efficacy of ultrasound combined with digital subtraction angiography (DSA)-guided pulsed radiofrequency (PRF) for perineal herpes zoster-related pain.

The gut microbiome, chronic kidney disease, and sarcopenia.

Sarcopenia is a prevalent condition in patients with chronic kidney disease (CKD), intricately linked to adverse prognoses, heightened cardiovascular risks, and increased mortality rates. Extensive studies have found a close and complex association between gut microbiota, kidney and muscle. On one front, patients with CKD manifest disturbances in gut microbiota and alterations in serum metabolites.

Evaluating safety and efficacy of plastic versus metal stenting in malignant hilar biliary obstruction: a systematic review and meta-analysis of randomized controlled trials.

Background: Stenting malignant hilar biliary obstruction (MHBO) is challenging due to its complex structure, and it is less effective than blockages in the distal bile duct area. Plastic stents (PSs) and metal stents (MSs) are commonly used for stenting MHBO. This study aims to compare the outcomes of PSs and MSs in MHBO patients.

The diagnostic performance of dual-energy CT imaging in cervical lymph node metastasis of papillary thyroid cancer: a meta-analysis.

Purpose: This meta-analysis aimed to evaluate the diagnostic efficacy of dual-energy computed tomography (DECT) in detecting cervical lymph node metastasis among papillary thyroid cancer (PTC) patients.

Methods: A comprehensive search across PubMed, Embase, and Web of Science databases was conducted to identify pertinent publications up to May 2024. This search focused on studies examining the diagnostic accuracy of DECT in detecting cervical lymph node metastases in PTC patients.