Parameters of estrous cycles in albino rats normally and after injection of xenogenic cerebrospinal fluid.

We studied biological effects of xenogenic cerebrospinal fluid. Injection of the liquor to albino female rats during different periods of postnatal ontogeny induced changes in the dynamics of estrous cycles. Changes in the picture of vaginal smears, duration of estrous cycles, and proportion between their phases were found.

[Intensification of the interaction of IgG with C1q in the presence of melittin as a possible reason for anaphylaxis under the effect of bee venom].

The hydrophilic head of melittin (peptide from bee venom) has the amino acid sequence which is very close to the amino acid sequence of C1q-binding site of the IgG molecule. It was shown, that melittin caused the multiple growth of the interaction of C1q with IgG monoclonal antibody. We assume, that the appearance of melittin in blood causes the spontaneous antigen-independent aggregation of IgG and C1q with the following triggering of the classical pathway of the complement cascade and origin of C3a and C5a components.