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Prefrontal lactate predicts exercise-induced cognitive dysfunction in Gulf War Illness.
Am J Transl Res
April 2013
Division of Rheumatology, Immunology and Allergy; Department of Medicine, Georgetown University Medical Center Room 3004F 3rd Floor PHC Building, 3800 Reservoir Road, NW, Washington, DC 20007, USA.
Background: 25% to 30% of Veterans deployed to the 1990 to 1991 Persian Gulf War exhibit an idiopathic syndrome of chronic fatigue, exertional exhaustion, pain, hyperalgesia, cognitive and affective dysfunction known as Gulf War Illness (GWI).
Methods: Gulf War veterans (n=15) and sedentary veteran and civilian controls (n=11) completed a 2-back working memory test in an fMRI before and after two bicycle exercise stress test. We performed single voxel (1)H MRS to evaluate brain metabolic differences in the left anterior cingulate cortex and the changes associated with exercise.