12 results match your criteria: "George Washington UniversityWashington[Affiliation]"

Article Synopsis
  • * Nrf2 inhibitors are emerging as important targets for cancer research, and natural plant-based remedies containing phytochemicals, especially phenolic compounds, show promise in cancer prevention.
  • * The review highlights the potential of phenolic compounds and other bioactive agents as anticancer therapies through their ability to inhibit Nrf2, with a focus on their clinical applications.
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Osteitis pubis is a noninfectious inflammatory condition affecting the pubic symphysis. First described in a series of patients undergoing urologic procedures, it is an uncommon cause of lower abdominal and suprapubic pain. However, this condition can cause significant morbidity in patients affected, often requiring lengthy recovery periods.

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Uncorrelated Neural Firing in Mouse Visual Cortex during Spontaneous Retinal Waves.

Front Cell Neurosci

September 2017

Department of Pharmacology and Physiology, Institute for Neuroscience, The George Washington UniversityWashington, DC, United States.

Synchronous firing among the elements of forming circuits is critical for stabilization of synapses. Understanding the nature of these local network interactions during development can inform models of circuit formation. Within cortex, spontaneous activity changes throughout development.

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Humans engage in Interpersonal Synchrony (IPS) as they synchronize their own actions with that of a social partner over time. When humans engage in imitation/IPS behaviors, multiple regions in the frontal, temporal, and parietal cortices are activated including the putative Mirror Neuron Systems (Iacoboni, 2005; Buxbaum et al., 2014).

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Wound healing involves an orchestrated response that engages multiple processes, such as hemostasis, cellular migration, extracellular matrix synthesis, and in particular, inflammation. Using a murine model of cutaneous wound repair, the transcriptome was mapped from 12 h to 8 days post-injury, and in response to a multicomponent, multi-target natural product, Tr14. Using single-molecule RNA sequencing (RNA-seq), there were clear temporal changes in known transcripts related to wound healing pathways, and additional novel transcripts of both coding and non-coding genes.

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Background: Adolescent sexual risk taking and its consequences remain a global public health concern. Empirical evidence on the impact that social media has on sexual health behaviors among youth is sparse.

Objective: The study aimed to examine the relationship between social media and the change in sexual risk over time and whether parental monitoring moderates this relationship.

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Eccentric Exercise Program Design: A Periodization Model for Rehabilitation Applications.

Front Physiol

February 2017

Muscle Morphology, Mechanics and Performance Laboratory, Clinical Research Center-Human Performance Research Unit, Veterans Affairs Medical Center Washington, DC, USA.

The applied use of eccentric muscle actions for physical rehabilitation may utilize the framework of periodization. This approach may facilitate the safe introduction of eccentric exercise and appropriate management of the workload progression. The purpose of this data-driven Hypothesis and Theory paper is to present a periodization model for isokinetic eccentric strengthening of older adults in an outpatient rehabilitation setting.

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A growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at the International Conference on Frailty and Sarcopenia Research in Philadelphia, Pennsylvania. The purpose of this symposium was to provide a venue for basic science and clinical researchers and expert clinicians to discuss muscle quality in the context of skeletal muscle function deficit and other aging-related muscle dysfunctions.

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Background: The National HIV/AIDS Strategy calls for active surveillance programs for human immunodeficiency virus (HIV) to more accurately measure access to and retention in care across the HIV care continuum for persons living with HIV within their jurisdictions and to identify persons who may need public health services. However, traditional public health surveillance methods face substantial technological and privacy-related barriers to data sharing.

Objective: This study developed a novel data-sharing approach to improve the timeliness and quality of HIV surveillance data in three jurisdictions where persons may often travel across the borders of the District of Columbia, Maryland, and Virginia.

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Imagery As a Core Process in the Creativity of Successful and Awarded Artists and Scientists and Its Neurobiological Correlates.

Front Psychol

March 2016

Washington International Center for CreativityWashington, DC, USA; Department of Psychiatry and Behavioral Health, George Washington UniversityWashington, DC, USA; Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente MuñizMexico City, Mexico.

This perspective paper presents an integration of neuroimaging and phenomenological data obtained in a sample that included highly creative, internationally awarded scientists and/or artists. The cerebral blood flow was evaluated during the performance of standardized creativity tasks from the Torrance Tests of Creative Thinking Verbal Form. The phenomenological data comprised both, their experiences and processes related to their creative careers and their experiences during the performance of the creative thinking tasks during the acquisition of the brain imaging data.

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Psoriasis is a chronic inflammatory skin condition with significant physical and psychosocial comorbidity. A workshop of leading experts in dermatology and psychology with the purpose of better understanding the current role of psychological comorbidities in psoriasis was held by the International Psoriasis Council in November 2013. The role of stress reactivity with a focus on the hypothalamic-pituitary-adrenal axis was emphasized.

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