901 results match your criteria: "George Washington University Hospital.[Affiliation]"

Background: Endovascular aneurysm repair (EVAR) has become the predominant treatment for Abdominal aortic aneurysm (AAA). Racial disparity has been observed in EVAR but Asian Americans have been largely excluded from previous studies. This study aimed to comprehensively evaluate 30-day outcomes of Asian Americans undergoing EVAR for intact infrarenal AAA using a multi-institutional national database.

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Introduction: Granular cell tumors (GCT) are predominantly benign neoplasms composed by cells with abundant eosinophilic granular cytoplasm. Although the majority of GCTs exhibit a benign clinical course, a minority display cytological atypia and may exhibit aggressive, cancer-like behavior. Definitive evidence of malignancy in GCTs is reliably established only through the presence of metastasis.

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Background: Chronic or hard-to-heal wounds fail to proceed through an orderly and timely healing process, resulting in a lack of anatomic and functional integrity. Infection is a common driver of nonhealing processes; therefore, infection prevention and management are essential components to healing chronic wounds. Inexpensive specialized cleansers, such as pure hypochlorous acid (pHA), can be used to cleanse vulnerable wounds to reduce microbial burden, thereby reducing the risk of infection and significantly decreasing the likelihood of the patient developing a costly wound complication.

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Penetrating traumatic aortic injury (PTAI) is increasing in prevalence given the rise in firearm violence in the United States and is associated with significant morbidity and mortality. These injuries often result in hemorrhagic shock, with patients presenting in extremis or pulseless, traditionally requiring open approaches for repair. A rare but potentially devastating complication of firearm-related PTAI is bullet embolization.

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Background: Glucose levels obtained on the day of surgery may be predictive of complications following total knee arthroplasty (TKA). Established glucose thresholds for TKA are either nonspecific or have low predictive power. Therefore, the purpose of this study was to create data-driven hemoglobin A1c (HbA1c) and same-day glucose thresholds associated with varying risks of 90-day major and surgical site infection (SSI) complications following TKA.

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Pediatric Diffuse Lung Disease in Infants: Imaging Findings and Histopathologic Correlation.

Radiographics

November 2024

From the Department of Radiology (K.I.R.S., S.M.C., L.O.T.G., A.M.W., M.M.P., H.J.O., D.M.B., L.R.Y., J.B.R.) and Division of Anatomic Pathology (J.P.), Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (L.O.T.G., A.M.W., H.J.O., D.M.B., L.R.Y., J.P., J.B.R.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.M.P.); American College of Radiology Institute of Radiologic Pathology, Silver Spring, Md (D.M.B., J.P.L.); and George Washington University Hospital, Washington, DC (J.P.L.).

Childhood interstitial lung disease (chILD) encompasses a diverse group of genetic, infectious, and inflammatory conditions affecting infants and children. The recognition and understanding of these entities have highlighted the necessity for more accurate classification. This group of rare heterogeneous diseases comprises more than 200 different conditions and has a combined estimated prevalence of less than one patient per 100 000 children.

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Objective: Chronic limb-threatening ischemia (CLTI) due to isolated tibial occlusive disease is treated by either popliteal-distal bypass (PDB) or tibial angioplasty (TA), although there is limited data directly comparing efficacy and outcomes between these two treatment modalities. This study compares 30-day mortality and major adverse limb events following infrapopliteal bypass and TA in patients with CLTI.

Methods: Patients who underwent PDB for CLTI were extracted from American College of Surgeons National Surgical Quality Improvement Program targeted lower extremity open database, whereas patient with CLTI who underwent isolated TA were identified in the targeted lower extremity endovascular database.

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Background: Carotid endarterectomy (CEA) is an effective treatment for carotid stenosis. Previous studies yielded conflicting findings regarding postoperative outcomes after CEA when comparing those under general and locoregional anesthesia. However, these findings may be influenced by an inherent selection bias, as general anesthesia is frequently selected for more complex CEA.

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Laparoscopic lavage and drainage (LLD) emerged as an alternative to Hartmann's procedure (HP) for patients with diverticulitis and uncontained perforation. Although initially popular as a less invasive approach, its use in modern practice is in question. This summary will review the available literature to show techniques, outcomes, and indications.

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Article Synopsis
  • An epinephrine nasal spray (ENS) is being developed as an alternative to the standard intramuscular (IM) epinephrine for treating anaphylaxis.
  • A study compared the pharmacokinetic (how the drug is processed in the body) and pharmacodynamic (effects on the body) profiles of a 13.2 mg ENS with a 0.3 mg IM autoinjector among healthy adults.
  • Results showed that ENS produced higher and more sustained plasma epinephrine concentrations compared to the IM autoinjector, with similar impacts on heart rate and blood pressure across both treatments.
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Background: Surgery is the definitive treatment for colonic volvulus despite initial decompression therapy. In general surgery, African Americans were found to have higher risks of mortality and morbidities. However, racial disparity in colectomy outcomes for volvulus among African Americans had not been explored.

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  • The study investigates the relationship between dependent functional status (DFS) and 30-day outcomes in patients with ruptured and nonruptured abdominal aortic aneurysm (AAA) undergoing endovascular aneurysm repair (EVAR), highlighting the need for differentiated analysis due to previous study limitations.
  • Utilizing data from the American College of Surgeons database between 2012-2022, the researchers compared outcomes by stratifying patients based on their functional status, with a focus on matching those with DFS and independent functional status (IFS) in nonruptured cases.
  • Results showed that nonruptured patients with DFS had similar 30-day mortality rates as those with IFS, but a higher risk of requiring blood transfusions and longer hospital stays
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Article Synopsis
  • Open groin vascular surgeries are crucial for treating peripheral arterial diseases, but they come with risks, necessitating a reliable risk assessment tool for evaluating patient outcomes post-surgery.
  • This study created the GW groin score, a 30-day point-scoring risk calculator based on a large sample of over 129,000 surgery patients to gauge the likelihood of mortality and major complications after surgery.
  • The GW groin score showed strong predictive ability and was validated both internally and externally, indicating its effectiveness as a risk assessment tool for patients undergoing different types of open groin vascular procedures.
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  • The study introduces a new rib-sparing technique for thoracic corpectomy, which minimizes post-operative complications associated with rib removal during spinal surgery.
  • Researchers conducted a chart review of 36 corpectomies performed on 32 patients from 2015 to 2023, noting key metrics like estimated blood loss and operative time.
  • Results showed the technique was effective, with an average post-operative stay of 6.5 days, highlighting the advantages of using an ultrasonic bone scalpel for this procedure.
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Article Synopsis
  • - Periprosthetic joint infections (PJI) after total knee arthroplasty (TKA) lead to significant health issues and costs, and existing methods to minimize these infections show promise but need national-level validation.
  • - A nationwide study analyzed data from over 860,000 patients and found a decline in septic revision rates from 0.75% in 2010 to 0.69% in 2019, with notable reductions in high-risk groups.
  • - Results suggest that current prevention strategies for PJIs are effective on a national scale, emphasizing the need for ongoing research to explore additional measures to further decrease these complications.
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Background: Due to the multiorgan effects of liver disease, surgical patients with liver disease have an increased risk of perioperative complications. With revision total hip and knee arthroplasty surgeries increasing, it is important to determine the effects of liver disease in this patient population. The purpose of this study was to evaluate the impact of underlying liver disease on postoperative outcomes following revision total joint arthroplasty (TJA).

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  • Elevated mammographic density (MD) is a significant risk factor for breast cancer, and this study investigates how factors like childbirth, age at first birth, and breastfeeding relate to MD in a large group of women across different countries.
  • The research analyzed data from 11,755 women aged 35-85 years, focusing on how factors such as the number of births and the timing of the first birth influence measurements of MD.
  • The findings suggest that having more children decreases MD, while older age at first birth is linked to higher MD, particularly in post-menopausal women, highlighting the complex relationships between reproductive factors and breast density.
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Antibiotic Prophylaxis for Genitourinary Procedures in Patients with Artificial Joint Replacement and Artificial Heart Valves.

Urol Clin North Am

November 2024

Department of Urology, George Washington University Hospital, 2150 Pennsylvania Avenue Northwest Suite 3-417, Washington, DC 20037, USA.

Prosthetic joint infection (PJI) and prosthetic valve endocarditis (PVE) are uncommon but serious complications. According to current best practice statements, prior to a genitourinary procedure, patients with prosthetic joints should receive antibiotic prophylaxis if they are within 2 years of arthroplasty, if they are high risk for infection due to their individual comorbidities, or if the procedure poses a high risk for bacteremia. Patients with prosthetic valves should not receive antibiotic prophylaxis for the sole purpose of prevention of endocarditis.

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Surgical site infections (SSIs) represent a major source of postoperative complications adversely impacting morbidity and mortality indices in surgical care. The discovery of antibiotics in the mid-20th century, and their ensuing use for preoperative antimicrobial bowel preparation and prophylaxis, drastically reduced the occurrence of SSIs providing a major tool to surgeons of various specialties, including urology. Because, the appropriate use of these antimicrobials is critical for their continued safety and efficacy, an understanding of the recommendations guiding their application is essential for all surgeons.

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Background: Single-segment great saphenous vein (ssGSV) is the gold standard conduit for femoral-tibial bypasses in patients with critical limb-threatening ischemia (CLTI). In the absence of a good single-segment saphenous vein, alternative options are prosthetic grafts or spliced-vein (SpV) conduits. Although SpV conduits may provide better long-term patency/limb salvage, prosthetic grafts are more often the chosen conduit due to shorter operative and presumably better immediate postoperative outcomes; nevertheless, there are little data supporting this practice.

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Endocrine Disruptors in Pregnancy: Effects on Mothers and Fetuses-A Review.

J Clin Med

September 2024

Women's Specialty Care of Florida, Pediatrix Medical Group, Fort Lauderdale, FL 33316, USA.

Article Synopsis
  • Endocrine disruptors are common in the environment and found in many consumer products, potentially affecting the endocrine and reproductive systems, particularly during pregnancy.
  • The review highlights specific substances like bisphenols, phthalates, organophosphates, and perfluoroalkyl substances, and their negative impacts on pregnancy and fetal development based on literature findings.
  • Despite numerous studies indicating health risks, it's difficult to establish clear conclusions or guidelines regarding endocrine disruptors, emphasizing the need for more research to ensure the safety of pregnant individuals and society as a whole.
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Background: Malnutrition is particularly pertinent in patients undergoing vascular surgery, who frequently present with a high burden of comorbidities and advanced age that can impede nutrient absorption. While previous studies have established that vascular surgery patients with malnutrition had poorer outcomes, the impact of nutritional status in patients undergoing endovascular aneurysm repair (EVAR) has not yet been investigated. Therefore, this study aimed to assess the effect of malnutrition on 30-day outcomes following non-ruptured EVAR.

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Tranexamic Acid Is Not Associated With a Change in Infection Risk in Trauma Patients.

J Surg Res

November 2024

Department of Surgery, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Surgery, The George Washington University Hospital, Washington, District of Columbia. Electronic address:

Introduction: Tranexamic acid (TXA) has been used as an adjunct in traumatic hemorrhage management. Outside of trauma, TXA has been used to limit blood loss across multiple surgical fields. TXA has also been found to have an immune-modulating effect, reducing postoperative infection rates.

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Background: Annually, nearly 3 million individuals in the US are hospitalized after experiencing a traumatic injury (e.g., serious automobile crash, gunshot wound, stab injury).

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