1,133 results match your criteria: "George Emil Palade University of Medicine[Affiliation]"

Enhanced long short-term memory architectures for chaotic systems modeling: An extensive study on the Lorenz system.

Chaos

December 2024

Department of Electrical Engineering and Information Technology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Târgu Mureş 540139, Romania.

Despite recent advancements in machine learning algorithms, well-established models like the Long Short-Term Memory (LSTM) are still widely used for modeling tasks. This paper introduces an enhanced LSTM variant and explores its capabilities in multiple input single output chaotic system modeling, offering a large-scale analysis that focuses on LSTM gate-level architecture, the effects of noise, non-stationary and dynamic behavior modeling, system parameter drifts, and short- and long-term forecasting. The experimental evaluation is performed on datasets generated using MATLAB, where the Lorenz and Rössler system equations are implemented and simulated in various scenarios.

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Implications of Preoperative C-Reactive Protein Levels in Heart Transplant Patients-A Single-Center Retrospective Study.

J Clin Med

December 2024

Department of Cell and Molecular Biology, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania.

: Heart transplant is the final therapeutic option for end-stage heart failure patients. It has been used with increasing success as a surgical procedure, greatly influenced by advances in diagnostic and prognostic tools. The aim of this paper was to study potential implications of C-reactive protein (CRP) in patients who underwent heart transplants.

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Interest in the transition of care for cystic fibrosis (CF) patients has grown significantly over time, driven by advancements in treatment that have extended life expectancy. As more CF patients survive into adulthood, the need for structured transition strategies has become a priority for healthcare systems worldwide. Transition programs for CF differ globally, reflecting varying resources and healthcare systems.

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: The objective of this study is to explore potential correlations between prostate volume, LUTS, and IIEF, with a particular emphasis on the relationship between prostate dimensions-width, height, and length-and both LUTS and IIEF and to assess patients based on risk factors such as hypertension, diabetes, cardiovascular disease, smoking, alcohol consumption, and PSA levels. : A retrospective multicenter study was conducted between January 2007 and December 2023, focusing on male patients over the age of 40. The study evaluated hypertension, diabetes, cardiovascular diseases, smoking, alcohol consumption, and lower urinary tract symptoms (LUTS) through the completion of the IPSS and QoL questionnaires, sexual function using the IIEF-15, and PSA levels.

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Clinicopathological Parameters and Immunohistochemical Profiles in Correlation with MRI Characteristics in Glioblastomas.

Int J Mol Sci

December 2024

Department of Anatomy and Embryology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mures, 38 Gheorghe Marinescu Str., 540142 Târgu Mures, Romania.

Glioblastoma is considered the most aggressive tumor of the central nervous system. The tumor microenvironment includes several components, such as endothelial cells, immune cells, and extracellular matrix components like matrix metalloproteinase-9 (MMP-9), which facilitates the proliferation of endothelial cells with pro-angiogenic roles. The MRI characteristics of glioblastomas can contribute to determining the prognosis.

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Unlocking the Potential of Pyrrole: Recent Advances in New Pyrrole-Containing Compounds with Antibacterial Potential.

Int J Mol Sci

November 2024

Scientific Center for Drug Research, Pharmaceutical and Toxicological Chemistry Department, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165 Bd. Stefan Cel Mare si Sfant, MD-2004 Chisinau, Moldova.

Nitrogen heterocycles are valuable structural elements in the molecules of antibacterial drugs approved and used to treat bacterial infections. Pyrrole is a five-atom heterocycle found in many natural compounds with biological activity, including antibacterial activity. Numerous compounds are being develop based on the pyrrole heterocycle as new potential antibacterial drugs.

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Endometriosis is a benign disease but with malignant behavior, sharing numerous features with cancers. Endometriosis is the development of endometrial tissue outside the uterus, with the presence of both glands and stroma. Approximately 10% of women of reproductive age suffer from endometriosis; it involves high social costs and affects the patient's quality of life.

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This study aimed to synthesize palladium nanoparticles (PdNPs) using bioactive compounds from aqueous extracts of species (, , and ) with potential biomedical applications. To optimize PdNPs biosynthesis, various parameters were explored, including the concentration of PdCl, the extract-to-PdCl ratio, and the pH of the solution. The nanoparticles were characterized using ultraviolet/visible spectroscopy (UV/Vis), Fourier-transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS).

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Impact of smoking exposure on disease progression in high risk and very high-risk nonmuscle invasive bladder cancer patients undergoing BCG therapy.

Urol Oncol

December 2024

Unit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo and Carlo, Via A. Di Rudini 8, Milan 20142, Italy. Electronic address:

Introduction: The nonmuscle invasive bladder cancer treated with BCG instillations in patients who smoke could potentially lead to poorer oncological results in the light of the new EAU risk groups classification for NMIBC that did not include BCG treated patients or smoking status.

Patient And Methods: Outcomes from 1313 patients with nonmuscle invasive bladder cancer treated with TURBT, re-TURBT and BCG instillations at 13 academic hospital centers, since 2002, has been included in this retrospective study. The study variables, including cumulative smoking exposure have been analyzed.

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Brain-derived neurotrophic factor as a promising neuromarker which could predict psychomotor developmental impairment in children with unrepaired congenital heart defects.

Int J Dev Neurosci

December 2024

Clinic of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of Targu Mureș, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mureș, 540142, Romania.

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The advancements of technological devices and software are putting mixed reality in the frontline of teaching medical personnel. The Microsoft HoloLens 2 offers a unique 3D visualization of a hologram in a physical, real environment and allows the urologists to interact with it. This review provides a state-of-the-art analysis of the applications of the HoloLens in a medical and healthcare context of teaching through simulation designed for medical students, nurses, residents especially in urology.

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Article Synopsis
  • About 70% of bladder cancer cases are non-muscle invasive (NMIBC) and inflammation, influenced by factors like smoking, affects treatment outcomes with BCG therapy.
  • A study analyzed data from 1,313 NMIBC patients to examine how smoking and systemic inflammation impact the effectiveness of BCG using a machine-learning algorithm.
  • The results indicated that both smoking status and specific inflammatory markers can significantly predict the risk of disease progression, highlighting the need for tailored treatment strategies and further research to confirm the findings.
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Steroidal 5α-reductase type 2 (S5αR2) is a key enzyme involved in the conversion of testosterone (TST) to dihydrotestosterone (DHT), a crucial process in the development of benign prostatic hyperplasia (BPH). Phytosterols (PSs), natural plant-derived compounds, have been proposed as potential inhibitors of S5αR2, but studies on their efficacy are limited. This study evaluates the inhibitory effects of three PSs (β-sitosterol, stigmasterol, and campesterol) on S5αR2 activity using a combined in vitro and in silico approach.

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In Silico Study of the Potential Inhibitory Effects on DNA Gyrase of Some Hypothetical Fluoroquinolone-Tetracycline Hybrids.

Pharmaceuticals (Basel)

November 2024

Pharmaceutical and Therapeutic Chemistry Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

Background/objectives: Despite the discovery of antibiotics, bacterial infections persist globally, exacerbated by rising antimicrobial resistance that results in millions of cases, increased healthcare costs, and more extended hospital stays. The urgent need for new antibacterial drugs continues as resistance evolves. Fluoroquinolones and tetracyclines are versatile antibiotics that are effective against various bacterial infections.

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Innovative Epicardial Bigels Containing Amiodarone Hydrochloride: Pharmacotechnical and Analytical Characterization.

Pharmaceuticals (Basel)

November 2024

Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

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Tuberculosis is the primary cause of death due to infection in the world. Identification of in sputum is a diagnostic test, which can be used in screening programs-especially in countries with a high incidence of tuberculosis-to identify and treat those persons with the highest risk of disseminating the infection. We previously developed an algorithm which is able to automatically detect mycobacteria on tissue; in particular, our algorithm identified acid-fast bacilli on tissue with 100% specificity, 95.

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: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are complex diseases that require precise diagnosis and management. The ESC risk score has been used in both conditions. We assessed the relationship between the EmPHasis-10 questionnaire (patient subjective evaluation) and objective assessment using endorsed tools (simplified four-strata risk assessment and right ventricular imaging by transthoracic echocardiography).

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The purpose of this study was to assess the microbial composition and density of subgingival plaque samples for periodontal pathogens while correlating the values with glycemic control levels via glycated hemoglobin (HbA1c), a type of hemoglobin that has chemically linked glucose, in type I diabetes individuals who will undergo complex oral rehabilitation through orthodontic treatment and implant surgery. A cohort of 42 adults with type I diabetes were included in this study. The subjects sustained a comprehensive periodontal clinical examination as well as microbiological assessments of their subgingival plaque samples through quantitative real-time PCR.

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The Impact of Heart Failure Chronic Treatment Prior to Cardiac Transplantation on Early Outcomes.

Medicina (Kaunas)

November 2024

Department of Cell and Molecular Biology, George Emil Palade University of Medicine Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

Article Synopsis
  • - Cardiac transplantation improves survival for patients with severe heart failure, but managing postoperative complications is difficult for doctors! - A study analyzed 50 patients who had heart transplants, focusing on how their pre-surgery heart failure treatments impacted complications after the surgery! - Results showed that Carvedilol was linked to lower 2-month mortality and helped prevent acute kidney injury, while Ramipril and Spironolactone were associated with shorter hospital stays and fewer complications!
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Overweight and obesity are well-known conditions that negatively impact the health and lifestyle of an individual. Bariatric surgery is one of the most efficient weight loss techniques. Besides the main effect on the bodyweight, improvement in the levels of inflammatory biomarkers, such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNFalfa), and others, has been observed.

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Extracellular vesicles (EVs) secreted by astrocytes (ADEVs) mediate numerous biological processes, providing insights into damage, repair, and protection following ischemic stroke (IS). This pilot study aimed to broaden the current knowledge on the astrocyte response to ischemia by dynamically assessing the aquaporin-4 (AQP4) and glial cell line-derived neurotrophic factor (GDNF) as cargo proteins of these vesicles in eighteen acute IS patients and nine controls. EV proteins were detected by Western blotting and followed 24 h (D1), 7 days (D7), and one month (M1) after symptoms onset.

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The Predictive Role of Inflammatory Biomarkers and Their Correlation with the Biochemical Profile in Patients with Vasculopathy Undergoing Surgery.

Int J Mol Sci

November 2024

Department of Chemistry and Medical Biochemistry, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureş, 540139 Targu Mures, Romania.

Article Synopsis
  • * The study evaluated 62 patients (both diabetic and non-diabetic) undergoing lower limb surgeries, measuring various inflammatory and biochemical markers before and after the procedures.
  • * Key findings showed correlations between specific markers (like IL-6 and TNF-α) and complications, indicating that monitoring these factors can help identify patients at higher risk and improve their management.
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  • A study on COVID-19 patients revealed that changes in lymphocyte subsets correlate with disease severity and outcomes, indicating that immune response variations could impact recovery.
  • Analyzed data from 53 patients categorized as mild, moderate, or severe showed significant decreases in certain T-lymphocyte populations (CD3+CD4+ and CD3+CD8+) in severe cases.
  • The findings suggest that measuring CD3+ lymphocyte levels can help predict fatal outcomes in COVID-19 patients, with higher accuracy when considering additional factors like age and inflammation markers.
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Posterior retroperitoneal laparoscopic adrenalectomy (PRLA) has emerged as a revolutionary, minimally invasive technique for adrenal gland surgery, offering significant advantages over traditional open approaches. This narrative review aims to provide a comprehensive update on PRLA, focusing on its anatomical foundations, surgical technique, and clinical implications. We conducted an extensive review of the current literature and surgical practices to elucidate the key aspects of PRLA.

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