Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease.

Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer's disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coeruleus-noradrenaline system overactivity and impaired emotion regulation could underlie agitation propensity, but to our knowledge this has not previously been investigated. A better understanding of the neurobiological underpinnings of agitation would help the development of targeted prevention and treatment strategies.

Development of a pandemic-related core set of quality indicators for quality and patient safety in University Hospitals in Germany.

Background: The COVID-19 pandemic entailed a global health crisis, significantly affecting medical service delivery in Germany as well as elsewhere. While intensive care capacities were overloaded by COVID cases, not only elective cases but also non-COVID cases requiring urgent treatment unexpectedly decreased, potentially leading to a deterioration in health outcomes. However, these developments were only uncovered retrospectively.

Effectiveness of hepatitis A immunization after pediatric liver transplantation: A retrospective observational analysis.

This retrospective study aimed to investigate the response to hepatitis A virus (HAV) immunization following liver transplantation. We analyzed 234 vaccination records of 284 children who underwent liver transplantation between January 2003 and July 2021, including annual serologic results. Of the 120 HAV-naïve patients, approximately 71% and 83% showed seroconversion after receiving 1 and 2 vaccine doses, respectively.

Influences of fat-protein-ratio and udder health parameters on the milk urea content of dairy cows.

The milk urea content is influenced by a large variety of factors, including the quantity and quality of protein fed, its balance with energy, diurnal fluctuations, management, season, analysis method, and also individual cow factors which include the health status of the cow. Aim of this study was to investigate the effects of metabolic disorders (ketosis, ruminal acidosis; indicated by the fat-protein-content of the milk) as well as high somatic cell counts and udder diseases on the milk urea content of dairy cows from different regions and farms across Germany. For this purpose, 5 independent data sets which contain information derived from monthly milk recordings (data sets A (6,140,342 test-data in 2015), data set D (439,767 test-data in 2020-2023), data set E (399,279 test-data in 2019-2020)) in combination with the differential somatic cell count (DSCC) in data set D and E, or individual recordings of daily feed and energy intake and milk analysis (data set B (58,235 test-data in 2014-2017) and data set C (352,346 test-data in 2018-2021)), were analyzed.

Artificial intelligence-based rapid brain volumetry substantially improves differential diagnosis in dementia.

Introduction: This study evaluates the clinical value of a deep learning-based artificial intelligence (AI) system that performs rapid brain volumetry with automatic lobe segmentation and age- and sex-adjusted percentile comparisons.

Methods: Fifty-five patients-17 with Alzheimer's disease (AD), 18 with frontotemporal dementia (FTD), and 20 healthy controls-underwent cranial magnetic resonance imaging scans. Two board-certified neuroradiologists (BCNR), two board-certified radiologists (BCR), and three radiology residents (RR) assessed the scans twice: first without AI support and then with AI assistance.

Molecules That Have Rarely Been Studied in Lymphatic Endothelial Cells.

A number of standard molecules are used for the molecular and histological characterization of lymphatic endothelial cells (LECs), including lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), Podoplanin (D2-40), VEGFR3, Prospero homeobox protein 1 (PROX1), and CD31. The number of molecules whose mutations cause lymphatic malformations or primary congenital lymphedema is considerable, but the majority of these diseases have not yet been characterized at the molecular level. Therefore, there is still considerable scope for molecular and functional studies of the lymphatic vasculature.

Effective Survey Methods for the Elusive Data Deficient Black Flying Squirrel () in Sabah, Malaysia Facilitate First Vocalisation Record.

Flying squirrels are nocturnal, gliding relatives of tree and ground squirrels (order Sciuridae). Despite 49 species existing, literature on Asiatic flying squirrels is scarce, thus they are overlooked in conservation action plans. Recently, three species of giant flying squirrel (, and ) were observed during a nocturnal mammal survey at the Rainforest Discovery Centre (RDC), an Eco centre at the edge of the Kabili-Sepilok forest reserve in Sepilok, Sabah (Malaysia, Borneo).

Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.

The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer's Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding.

Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study.

Background: Perivascular space (PVS) enlargement in ageing and Alzheimer's disease (AD) and the drivers of such a structural change in humans require longitudinal investigation. Elucidating the effects of demographic factors, hypertension, cerebrovascular dysfunction, and AD pathology on PVS dynamics could inform the role of PVS in brain health function as well as the complex pathophysiology of AD.

Methods: We studied PVS in centrum semiovale (CSO) and basal ganglia (BG) computationally over three to four annual visits in 503 participants (255 females; mean = 70.

Resilience of genetic diversity in forest trees over the Quaternary.

The effect of past environmental changes on the demography and genetic diversity of natural populations remains a contentious issue and has rarely been investigated across multiple, phylogenetically distant species. Here, we perform comparative population genomic analyses and demographic inferences for seven widely distributed and ecologically contrasting European forest tree species based on concerted sampling of 164 populations across their natural ranges. For all seven species, the effective population size, N, increased or remained stable over many glacial cycles and up to 15 million years in the most extreme cases.

Taxonomic and functional characterization of biofilms from a photovoltaic panel reveals high genetic and metabolic complexity of the communities.

Aims: Biofilms are complex microbial cell aggregates that attach to different surfaces in nature, industrial environments, or hospital settings. In photovoltaic panels (PVs), biofilms are related to significant energy conversion losses. In this study, our aim was to characterize the communities of microorganisms and the genes involved in biofilm formation.

The Functional Significance of Cardiac Looping: Comparative Embryology, Anatomy, and Physiology of the Looped Design of Vertebrate Hearts.

The flow path of vertebrate hearts has a looped configuration characterized by curved (sigmoid) and twisted (chiral) components. The looped heart design is phylogenetically conserved among vertebrates and is thought to represent a significant determinant of cardiac pumping function. It evolves during the embryonic period of development by a process called "cardiac looping".

L-Carnitine sustainably affects bioenergetic profile of bovine blastocysts and transcriptome profile of elongation-stage embryos.

In Brief: In the present study the sustainable effect of L-carnitine during the culture period on the post-transfer development was investigated. Taken together, we uncovered direct effects of L-carnitine on the bioenergetic profile of day 7 blastocysts along with sustainable effects on mtDNA copy numbers and transcriptome profile of bovine day 14 embryos.

Abstract: L-Carnitine (LC) is known to play key roles in lipid metabolism and antioxidative activity, implicating enhanced cryotolerance of bovine blastocysts.

Planar Core and Macrocyclic Shell Stabilized Atomically Precise Copper Nanocluster Catalyst for Efficient Hydroboration of C-C Multiple Bond.

Atomically precise metal nanoclusters (NCs) have become an important class of catalysts due to their catalytic activity, high surface area, and tailored active sites. However, the design and development of bond-forming reaction catalysts based on copper NCs are still in their early stages. Herein, we report the synthesis of an atomically precise copper nanocluster with a planar core and unique shell, [Cu(TBBT)(TPP)(CHN)H] () (TBBT: 4--butylbenzenethiol; TPP: triphenylphosphine), in high yield via a one-pot reduction method.

The impact of goal saliency and verbal information on selective imitation in 16- to 18-month-olds.

This study aimed to assess which action component (movement or goal) infants prioritize in their imitation behavior when they get information about its relevance from two important sources: perceptual goal saliency and experimenter's verbal information. 16- to 18-month-olds (N = 72) observed how the experimenter moved a toy mouse with a hopping or sliding movement onto one of two empty spaces (low goal saliency) or 2D circles (medium saliency), or inside one of two 3D houses (high saliency). Before the demonstration, the experimenter verbally announced the movement style or the goal.

Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age-Results from the Multicentre Observational DELCODE Study.

Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer's disease (AD) pathology and cognitive performance.

How to reduce the carbon footprint of the agricultural sector? Factors influencing farmers' decision to participate in carbon sequestration programs.

Mitigating climate change by sequestering carbon in agricultural soils through humus formation is a crucial component of sustainable agriculture. Humus programs that are designed to incentivize farmers to build more humus are still recent innovations, so current knowledge about farmers' motivation to participate is limited. This study examines the adoption of non-governmental humus programs to promote carbon sequestration by analyzing farmers' willingness to participate in humus programs and influential factors.

Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.

Background: Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear.

Objective: This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks.

Ovulatory cycle shifts in human motivational prioritisation of sex and food.

Previous research on the endogenous effects of ovarian hormones on motivational states in women has focused on sexual motivation. The Motivational Priority Shifts Hypothesis has a broader scope. It predicts a shift from somatic to reproductive motivation when fertile.

Better in sync: Temporal dynamics explain multisensory word-action-object learning in early development.

We investigated the temporal impact of multisensory settings on children's learning of word-object and action-object associations at 1- and 2-years of age. Specifically, we examined whether the temporal alignment of words and actions influenced the acquisition of novel word-action-object associations. We used a preferential looking and violation of expectation task in which infants and young children were first presented with two distinct word-object and action-object pairings either in a synchronous (overlapping in time) or sequential manner (one after the other).