3 results match your criteria: "Genomic Institute of Singapore[Affiliation]"
Single-Cell RNA-Seq Reveals LRRC75A-Expressing Cell Population Involved in VEGF Secretion of Multipotent Mesenchymal Stromal/Stem Cells Under Ischemia.
Stem Cells Transl Med
June 2023
Division of Cell-Based Therapeutic Products, National Institute of Health Sciences, Kanagawa, Japan.
Article Synopsis
- Human multipotent mesenchymal stromal/stem cells (MSCs) have potential for treating various diseases, but their effectiveness is limited by variations in quality and heterogeneity among cell populations.
- This study identified functional subpopulations of bone marrow-derived MSCs (BM-MSCs) that influence their ability to produce vascular endothelial growth factor (VEGF), which is important for angiogenic therapy.
- The research highlighted LRRC75A as a key marker for these effective subpopulations, showing that it regulates VEGF secretion under ischemic conditions, suggesting it could help improve the selection of MSCs for therapeutic purposes.
A System Based-Approach to Examine Host Response during Infection with Influenza A Virus Subtype H7N9 in Human and Avian Cells.
Cells
February 2020
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Although the influenza A virus H7N9 subtype circulates within several avian species, it can also infect humans with a severe disease outcome. To better understand the biology of the H7N9 virus we examined the host response to infection in avian and human cells. In this study we used the A/Anhui/1/2013 strain, which was isolated during the first wave of the H7N9 epidemic.
View Article and Find Full Text PDFTranslating gastric cancer genomics into targeted therapies.
Crit Rev Oncol Hematol
April 2016
Cancer Science Institute of Singapore, National University of Singapore, Singapore; Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore; Cancer Therapeutics and Stratified Oncology, Genomic Institute of Singapore, Singapore. Electronic address:
Gastric cancer is a common disease with limited treatment options and a poor prognosis. Many gastric cancers harbour potentially actionable targets, including over-expression and mutations in tyrosine kinase pathways. Agents have been developed against these targets with varying success- in particular, the use of trastuzumab in HER2-overexpressing gastric cancers has resulted in overall survival benefits.
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