Mikhail 'Misha' Blagosklonny's enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin.

The untimely passing of Dr. Mikhail "Misha" Blagosklonny has left a lasting void in geroscience and oncology. This review examines his profound contributions, focusing on his pioneering the Hyperfunction Theory and his advocacy for rapamycin, an mTOR inhibitor, as a therapeutic agent for lifespan extension.

Complete genome sequence of a winter season facilitates discovery of a novel subclade of cold-adapted species in the clade.

In temperate marine climate zones, seasonal changes in water temperature contribute to distinct populations of warm- and cold-water vibrios. We report here the complete genome sequence (BUSCO score=94.8) of the novel strain sp.

Student Attitudes Contribute to the Effectiveness of a Genomics CURE.

The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work and science, interest in science, and grit. We found, in general, that the attitudes students bring with them into the classroom contribute to two outcome measures, namely, learning as assessed by a pre- and postquiz and perceived self-reported benefits.

Climatology and trends of morning and evening surface-based temperature inversions in southwestern Pennsylvania with air quality implications.

Concerns over regional climate change include its impact on air quality. A major contributor to unhealthy air quality is surface-based temperature inversions. Poor air quality is a serious public health concern that is often addressed by public health agencies.

Draft Genome Sequence of Psychrotolerant sp. Strain VB17, Isolated from Marine Intertidal Sediment near Virginia Beach, Virginia.

We present the draft genome sequence of sp. strain VB17, which was isolated from Virginia Beach, Virginia, intertidal sediment. The 5.

Draft Genome Sequence of sp. Strain PC23-8, Isolated from a Freshwater Stream Impacted by Acid Mine Drainage.

We present the draft genome sequence of sp. strain PC23-8, a bacterium isolated from freshwater stream sediment downstream from acid mine drainage. The 6.

Investigating the effects of conductivity on zone overlap with EMMA: computer simulation and experiment.

In this paper, we demonstrate, using both experiment and simulation, how sample zone conductivity can affect plug-plug mixing in small molecule applications of electrophoretically mediated microanalysis (EMMA). The effectiveness of in-line mixing, which is driven by potential, can vary widely with experimental conditions. Using two small molecule systems, the effects of local conductivity differences between analyte plugs, reagent plugs and the BGE on EMMA analyses are examined.

A birdcage model for the Chinese Meridian System: part I. A channel as a transmission line.

The concept of Qi and the concept of channel are so closely related that they must be defined and comprehended simultaneously in a coordinated fashion. Once the nature of Qi is established in terms of physics, we may be able to explain the functional role that the channels play, as well as explain other Chinese medical terminology with a language of modem science. Based on the low electrical impedance characteristics of acupoints, we propose that the meridian channel is equivalent to an electromagnetic transmission line and the Qi is the electromagnetic (EM) standing wave riding on the line, with acupoints as its nodes.

Individual and coupled effects of echinoderm extracts and surface hydrophobicity on spore settlement and germination in the brown alga Hincksia irregularis.

Marine substrata possess cues that influence the behavior of fouling organisms. Initial adhesion of fouling algal zoospores to surfaces is also theorized to depend primarily upon interactions between substrata and spore cell bodies and flagellar membranes. In an effort to identify cues and surface characteristics that influence spore settlement and early development, the effects of bioactive echinoderm extracts, surface charge, and surface hydrophobicity were examined individually and in tandem on zoospore settlement and germination in Hincksia irregularis.

Empirical models of transverse relaxation for spherical magnetic perturbers.

Ferromagnetic or superparamagnetic particles as MRI contrast agent present many advantages for bringing about soft tissue contrast as compared to single-ion complexes. The classic microscopic outersphere theory that works successfully for small molecules in understanding the transverse relaxation rate 1/T(2) is not valid for these larger and stronger magnetic spheres. We categorize the relaxation behavior of the tissue-sphere system for ferromagnetic spherical perturbers in five diffusion regimes.

Mri measurements of T1, T2 and D for gels undergoing volume phase transition.

Gels consist of crosslinked polymer network swollen in solvent. The network of flexible long-chain molecules traps the liquid medium they are immersed in. Some gels undergo abrupt volume change, a phase transition process, by swelling-shrinking in response to external stimuli changes in solvent composition, temperature, pH, electric field, etc.

Masked intentions: the masquerade of killing thoughts used to justify dehydrating and starving people in a "persistent vegetative state" and people with other profound neurological impairments.

Denying food and water to profoundly impaired people who may not be conscious, or may only be "minimally" conscious, raises challenging ethical issues. While there is growing support for withdrawing/withholding food and water (assisted nutrition and hydration, or "AHN") from people described as being in a "persistent vegetative state" ("PVS") and people with other profound neurological impairments, such as advanced dementia, the issue remains controversial, and for many, unresolved. In this article, the author argues that if a profoundly impaired person is not imminently dying from a disease process, denying food and water causes him or her to die of dehydration and starvation.