17,060 results match your criteria: "Genetics of LDL Cholesterol"
Cardiovasc Diabetol
October 2024
Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA.
Medicina (Kaunas)
September 2024
Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.
Nutrients
October 2024
Department of Internal Medicine, Amsterdam University Medical Center, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.
Nutrients
October 2024
Department of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.
Genes (Basel)
October 2024
Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Background And Objectives: Phase I and phase II drug-metabolizing enzymes are crucial for the metabolism and elimination of various endogenous and exogenous compounds, such as small-molecule hormones, drugs, and xenobiotic carcinogens. While in vitro and animal studies have suggested a link between genetic mutations in these enzymes and an increased risk of cancer, human in vivo studies have provided limited supportive evidence.
Methods: Genome-wide association studies (GWASs) are a powerful tool for identifying genes associated with specific diseases by comparing two large groups of individuals.
Int J Mol Sci
October 2024
Guangxi Key Laboratory for Applied Fundamental Research of Zhuang Medicine-Key Laboratory Project under Guangxi Health Commission, Guangxi University of Chinese Medicine, Nanning 530001, China.
Polycystic ovary yndrome (PCOS) is a common metabolic disorder in women, which is usually associated with insulin resistance (IR) and chronic inflammation. Loureirin B (LrB) can effectively improve insulin resistance and alleviate chronic inflammation, and in order to investigate the therapeutic effect of LrB on polycystic ovary syndrome with insulin resistance (PCOS-IR), we conducted animal experiments. A PCOS-IR rat model was established by feeding a high-fat diet combined with letrozole (1 mg/kg·d for 21 days).
View Article and Find Full Text PDFInt J Mol Sci
October 2024
Centre for Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Eur J Prev Cardiol
October 2024
Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, Arizona, USA.
Aims: Lipoprotein(a) [Lp(a)] levels are known to be mainly genetically determined. However, only scarce data are available on the intra-individual variability of Lp(a) levels across time.
Methods: We included adult patients (≥18 years old) who had baseline and follow-up Lp(a) measurements (between 1997 and 2024) with a minimum of one year apart.
Int J Cardiol
January 2025
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland; Department of Cardiology and Adult Congenital Heart Diseases, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. Electronic address:
Background: Despite advancements in early diagnosis and effective medications in last decade, most heterozygous familial hypercholesterolemia (heFH) patients still fail to achieve their low-density lipoprotein cholesterol (LDL-C) goals and remain at residual cardiovascular disease risk. We present recent data from the regional FH registry in Poland, highlighting the challenges and real-life clinical management of FH patients.
Methods: The registry is held at the Regional Centre for Rare Diseases, founded in 2016, at the 2nd largest, supraregional hospital in Poland, where >80 different rare diseases in patients from all over Poland are diagnosed and treated, including phenotypically or genetically diagnosed FH patients.
Biomed Pharmacother
November 2024
Teaching Hospital of Shenyang Pharmaceutical University, General Hospital of Northern Theater Command, Shenyang 110016, PR China. Electronic address:
Sterol regulatory element binding proteins (SREBPs) are a series of cholesterol-related transcription factors. Their role in regulating brain cholesterol biosynthesis, amyloid accumulation, and tau tangles formation has been intensively studied in protein-protein interaction analysis based on genes in clinical databases. SREBPs play an important role in maintaining cholesterol homeostasis in the brain.
View Article and Find Full Text PDFFront Immunol
October 2024
Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, China.
Introduction: Pike perch () is a predatory freshwater fish, which is highly popular amongst consumers, owing to its white flesh with a delicate structure and mild flavor. Compared to wild pike perch, the diet of farmed ones has shifted from natural food to artificial feeds. These changes would affect the gut flora of the pike perch.
View Article and Find Full Text PDFMol Biol Rep
October 2024
College of Dental Medicine, Lincoln Memorial University, LMU tower, 1705 St. Mary Street, Knoxville, TN, 37917, USA.
Clin Case Rep
October 2024
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India.
Key Clinical Message: Early recognition and management of familial hypercholesterolemia (FH) are crucial, especially in patients with extensive xanthomas and premature coronary artery disease. Prompt diagnosis and aggressive lipid-lowering therapy can significantly reduce morbidity and mortality rates. Careful clinical assessment in resource-limited settings is essential for optimal outcomes.
View Article and Find Full Text PDFZhonghua Xin Xue Guan Bing Za Zhi
October 2024
Second Medical Center of Chinese People's Liberation Army General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853, China.
J Matern Fetal Neonatal Med
December 2024
Laboratory of Genetic Disease and Perinatal Medicine and Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Lancet Diabetes Endocrinol
December 2024
Amryt Pharmaceuticals, Dublin, Ireland.
Tzu Chi Med J
September 2024
Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan.
A decrease in the levels of low-density lipoprotein receptors (LDLRs) leads to the accumulation of LDL cholesterol (LDL-C) in the bloodstream, resulting in hypercholesterolemia and atherosclerotic cardiovascular diseases. Increasing the expression level or inducing the activity of LDLR in hepatocytes can effectively control hypercholesterolemia. Proprotein convertase subtilisin/kexin type 9 (PCSK9) protein, primarily produced in the liver, promotes the degradation of LDLR.
View Article and Find Full Text PDFCardiovasc Diabetol
October 2024
Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Aims: The association and co-isolation of low-density lipoproteins (LDL) and extracellular vesicles (EVs) have been shown in blood plasma. Here we explore this relationship to better understand the role of EVs in atherogenesis.
Methods And Results: Wild type (WT), PCSK9, and LDLR C57BL/6 mice were used in this study.
Sci Rep
October 2024
Department of Pulmonology, Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, China.
Diabetes
January 2025
Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
The prevalence of type 2 diabetes (T2D) varies among populations of different races/ethnicities. The influence of genetically proxied LDL cholesterol lowering through proprotein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) on T2D in non-European populations is not well established. A drug target Mendelian randomization approach was used to assess the effects of PCSK9 and HMGCR inhibition on T2D risk and glycemic traits in five populations: East Asian (EAS), South Asian (SAS), Hispanic (HISP), African (AFR), and Europe (EUR).
View Article and Find Full Text PDFAlzheimers Res Ther
October 2024
Institute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London, WC1E 6HX, UK.
Nutrients
October 2024
División de Estudios Sociales, Universidad Iberoamericana Ciudad de México, Mexico City 01219, Mexico.
J Clin Med
September 2024
Sorbonne-Université, Assistance Publique-Hôpitaux de Paris (APHP), INSERM Unité de Recherche sur les Maladies Cardiovasculaires et Métaboliques (UMRS) 1166, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
J Clin Pharmacol
October 2024
Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China.
BMC Med
October 2024
Children and Reproductive Health, Institute of Women, Jinan, Shandong, 250012, China.