160 results match your criteria: "General University Hospital Attikon[Affiliation]"

Prevalence of SARS-COV-2 infection and outcomes in Greek sarcoidosis patients.

Sarcoidosis Vasc Diffuse Lung Dis

December 2024

Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Background And Aim: There is limited data on the prevalence of SARS-COV-2 in sarcoidosis patients and the underlying parameters linked to severity. We aimed to conduct a national multicenter study to explore the prevalence of SARS-COV-2 in sarcoidosis patients and investigate its impact on hospitalization and infection rates, describe the characteristics of the infected population and assess the role of these characteristics in determining the likelihood of infection or hospitalization.

Methods: We recruited all the adult sarcoidosis patients with who were examined across eight Greek Health Interstitial Lung Disease Referral Centers from the beginning of the pandemic until August 1, 2022.

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Background: Interstitial lung disease (ILD) is rarer in children (chILD) than adults, but with increasing diagnostic awareness, more cases are being discovered. chILD prognosis is often poor, but increasing numbers are now surviving into adulthood.

Aim: To characterize chILD-survivors and identify their impact on adult-ILD centers.

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Beneficial Impact of Vaccination Against SARS-CoV-2 on the Mental Health of IPF Patients.

Adv Respir Med

November 2024

2nd Pulmonary Medicine Department, General University Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Article Synopsis
  • Depression and anxiety are common issues for patients with idiopathic pulmonary fibrosis (IPF), negatively impacting their quality of life, especially during the COVID-19 pandemic.
  • A study aimed to evaluate how COVID-19 vaccination affects these mental health issues in IPF patients, using the Hospital Anxiety and Depression Scale (HADS) to measure changes before and after vaccination.
  • Results showed a significant improvement in both anxiety and depression scores one month after vaccination, indicating that the vaccine may have beneficial effects on mental health for IPF patients, regardless of factors like age or previous mental health history.
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Epidemiological Trends of Mucormycosis in Europe, Comparison with Other Continents.

Mycopathologia

November 2024

Fourth Department of Internal Medicine, General University Hospital "Attikon", National and Kapodistrian University of Athens, 12462, Athens, Greece.

Article Synopsis
  • * The incidence in developed countries is relatively low (0.06 to 0.3 cases per 100,000), but in India, it spikes to about 14 cases per 100,000, making it significantly more prevalent there than in Europe, where rates range from 0.04 to 0.12.
  • * Diabetes mellitus is the most common risk factor globally for mucormycosis, with varying patterns; in Europe, hematological cancers are more prevalent, while the disease often appears in patients
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During the coronavirus disease-19 (COVID-19) pandemic, there was an unprecedented requirement for hospital bed availability. The present study aimed to examine the characteristics and outcomes of patients hospitalized in a COVID-19 unit that operated as a novel middle-step unit in Greece. The present study aimed to determine whether the middle-step unit supported the central general hospitals; thus, highlighting the potential of these models in future pandemics.

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A 60-year-old male patient with a previously unremarkable medical history presented with unilateral eyelid ptosis and binocular diplopia in the past year. Clinical and laboratory workup confirmed the diagnosis of ocular myasthenia gravis. In addition, further workup with orbital MRI performed due to exophthalmos and unilateral ophthalmoplegia demonstrated findings compatible with thyroid eye disease, which were further verified by antibody testing.

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Article Synopsis
  • Autoimmune GFAP astrocytopathy is a neurological disorder characterized by antibodies attacking GFAP, leading to symptoms like headaches, visual issues, and psychiatric disturbances, often manifesting as meningoencephalitis.
  • The condition may be triggered by neoplasms or viral infections, and about 20-30% of patients experience relapses after initial treatment, which responds favorably to steroids.
  • The review includes two case studies, explores the role of anti-GFAP antibodies, and discusses clinical features, imaging findings, and treatment strategies for this emerging disorder.
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"Bubbly lung", a honeycombing variant with more favorable outcome.

Respir Investig

November 2024

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st St. SW Rochester, MN 55905, Rochester, MN, USA.

Background: Although radiologic honeycombing is generally associated with progressive fibrosis and a dismal prognosis, some patients display an unexpectedly indolent clinical course. We aimed to assess for variants of honeycombing associated with a more favorable prognosis.

Methods: A computer-assisted search was conducted to identify patients encountered at Mayo Clinic from 1998 to 2022 who had undergone chest CT that manifested exuberant honeycombing.

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Article Synopsis
  • Pulmonary alveolar proteinosis (PAP) is a rare lung syndrome characterized by the accumulation of proteinaceous material, leading to symptoms like progressive dyspnea and hypoxemia, with various diagnostic methods such as CT scans, bronchoalveolar lavage, and genetic testing suggested for evaluation.
  • A European Respiratory Society Task Force, comprised of diverse experts, developed evidence-based guidelines for diagnosing and managing PAP using a systematic review of literature and the GRADE approach for assessing the strength of recommendations.
  • The Task Force provided specific management recommendations, including whole lung lavage, GM-CSF therapy, and potential treatments like rituximab, alongside diagnostic approaches involving GM-CSF antibody
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Article Synopsis
  • Scientists wanted to see how different storage solutions affect blood platelets that are treated to kill germs.
  • They tested platelets stored in plasma and Platelet Additive Solutions (PAS) from the same donors and checked their health on days 1, 3, and 5.
  • Results showed that PAS kept the platelets healthier than plasma, but both types had less ability to stop bleeding over time.
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Purpose: Tetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients.

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Interdepartmental miscommunication regarding radiology: Addressing chronic challenges and exploring solutions.

World J Radiol

May 2024

Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Centre of Excellence, Croix-Rousse Hospital, Lyon University Hospital, Lyon 69004, France.

Effective communication and collaboration among healthcare professionals are crucial for delivering high-quality patient care. Interdepartmental miscommunication poses a significant challenge to healthcare systems, potentially undermining the quality of healthcare services provided. In the same manner, communication barriers between referring physicians and radiologists can specifically affect radiology services and patient outcomes.

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One of the World Health Organization's targets for the 2030 viral hepatitis elimination strategy is to reduce new hepatitis C (HCV) infections. In Athens, Greece, people who inject drugs (PWID) have a high HCV prevalence, with increasing trends since the 2000s. This analysis aims to assess primary HCV incidence among PWID during 2012-2020.

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Introduction: Silent pauses are regarded as integral components of the temporal organization of speech. However, it has also been hypothesized that they serve as markers for internal cognitive processes, including word access, monitoring, planning, and memory functions. Although existing evidence across various pathological populations underscores the importance of investigating silent pauses' characteristics, particularly in terms of frequency and duration, there is a scarcity of data within the domain of post-stroke aphasia.

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Background: Several rare surfactant-related gene (SRG) variants associated with interstitial lung disease are suspected to be associated with lung cancer, but data are missing. We aimed to study the epidemiology and phenotype of lung cancer in an international cohort of SRG variant carriers.

Methods: We conducted a cross-sectional study of all adults with SRG variants in the OrphaLung network and compared lung cancer risk with telomere-related gene (TRG) variant carriers.

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Article Synopsis
  • High mortality rates among people who inject drugs (PWID) in Greece, primarily due to overdose and HIV, have been documented in a study covering 2018-2022.
  • The study found a crude mortality rate of 3.52 deaths per 100 person-years, with notable increases in Athens, and highlighted that younger, daily injectors not in treatment had higher risks of death.
  • Results indicate an urgent need for preventive measures, especially in Thessaloniki, and suggest that the COVID-19 pandemic may have exacerbated these trends in Athens.
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Similarities and differences of interstitial lung disease associated with pathogenic variants in SFTPC and ABCA3 in adults.

Respirology

April 2024

Department of Respiratory Medicine, National Reference Centre for Rare Pulmonary Diseases, Hospices civils de Lyon, Université Lyon 1, UMR754, INRAE, ERN-LUNG, Lyon, France.

Background And Objective: Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults.

Methods: We conducted a multicentre retrospective study of all consecutive adult patients diagnosed with ILD associated with variants in SFTPC or ABCA3 in the French rare pulmonary diseases network, OrphaLung. Variants and chest computed tomography (CT) features were centrally reviewed.

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Investigating Aphasia Recovery: Demographic and Clinical Factors.

Brain Sci

December 2023

Neuropsychology & Language Disorders Unit, 1st Neurology Department, Eginition Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.

Post-stroke language recovery remains one of the main unresolved topics in the field of aphasia. In recent years, there have been efforts to identify specific factors that could potentially lead to improved language recovery. However, the exact relationship between the recovery of particular language functions and possible predictors, such as demographic or lesion variables, is yet to be fully understood.

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Unlabelled: Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe hyperinflammatory condition that may occur following SARS-CoV-2 infection. This retrospective, descriptive study of children hospitalized with multisystem inflammatory syndrome in children (MIS-C) in 12 tertiary care centers from 3/11/2020 to 12/31/2021. Demographics, clinical and laboratory characteristics, treatment and outcomes are described.

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Effectiveness and Safety of Biosimilars in Pediatric Non-infectious Uveitis: Real-Life Data from the International AIDA Network Uveitis Registry.

Ophthalmol Ther

March 2024

Department of Medicine, Surgery and Neurosciences, Ophthalmology Unit, ERN RITA Center, Policlinico "Le Scotte", University of Siena, Viale Bracci 16, 53100, Siena, Italy.

Article Synopsis
  • Many biological drug patents have expired, leading to the development of biosimilar agents (BIOs), but their use in children raises concerns, prompting a study on their efficacy and safety for treating pediatric non-infectious uveitis (NIU).
  • Data collected from pediatric patients treated with TNF inhibitors BIOs showed a significant decrease in flare-ups and ocular complications, as well as a reduction in the need for glucocorticoids during treatment.
  • The study included 47 patients, demonstrating strong treatment retention rates and maintaining visual acuity throughout the therapy, while only recording a few minor adverse events.
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