5 results match your criteria: "General Hospital of Xizang Military Region[Affiliation]"
Butyrate Metabolism-Related Gene Signature in Tumor Immune Microenvironment in Lung Adenocarcinoma: A Comprehensive Bioinformatics Study.
Immun Inflamm Dis
December 2024
Department of Respiratory Disease, Xinqiao Hospital, Army Medical University, Chongqing, China.
Article Synopsis
- The research investigates the role of butyrate metabolism-related genes (BMRGs) in the immune microenvironment of lung adenocarcinoma (LUAD), revealing their suppressive effects on tumor formation.
- By analyzing The Cancer Genome Atlas dataset, 38 differentially expressed BMRGs were identified, leading to the development of a prognostic signature that indicates high-risk scores are linked to poor survival outcomes in LUAD patients.
- A key gene, PTGDS, was found to have significant associations with T cells and specific immune pathways, suggesting that targeting butyrate metabolism and T cell interactions could offer new cancer treatment strategies.
Assessing oral and toothbrush microbial profiles among high-altitude individuals with and without periodontal disease: a case-control study.
BMC Oral Health
August 2024
Northwest MINZU University, Lanzhou, Gansu, 730030, China.
Background: Periodontitis is the sixth-most common disease worldwide. The oral microbiome composition and its association with Periodontal disease (PD) have been largely explored; however, limited studies have explored the microbial profiles of both oral and toothbrushes in patients with PD. Thus, this study aimed to ascertain the oral and toothbrushes microbial composition in high-altitude populations, hypothesizing that their correlation with periodontal health would differ from those at lower altitudes, potentially indicating links between environmental factors, microbial colonization patterns, and periodontal health in distinct geographic contexts.
View Article and Find Full Text PDF[Knock-down of long noncoding RNA H19 (lncRNA H19) promotes human colorectal cell autophagy and inhibits cell apoptosis induced by lipopolysaccharide].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
June 2024
Department of Nuclear Medicine, General Hospital of Xizang Military Region, Lasa 850000, China. *Corresponding author, E-mail:
Objective To investigate the expression levels of lncRNA H19 in ulcerative colitis (UC) patients and its role in UC. Methods Colonic mucosa and serum samples were collected from 25 UC patients and 25 healthy individuals at the General Hospital of Xizang Military Region. The expression levels of lncRNA H19 were detected, and the receiver operating characteristic (ROC) curve analysis was performed using serum samples.
View Article and Find Full Text PDFA New Mouse Model for Usher Syndrome Crossing Kunming Mice with CBA/J Mice.
Gene
September 2024
Center of Clinical Aerospace Medicine, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China; Department of Aviation Medicine, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. Electronic address:
Article Synopsis
- Researchers discovered a strain of Kunming mice (KM) displaying symptoms similar to Usher Syndrome, including abnormal electroretinogram (ERG) readings and high auditory brainstem response (ABR) thresholds, by crossbreeding KM with CBA/CaJ mice.
- This study involved analyzing the offspring from crossbreeding KM with CBA/J mice using various methods like ERG readings, ABR tests, and genetic analyses to assess their phenotypes and genotypes.
- Results indicated that F1 hybrid mice had no ERG waveforms but normal ABR results, while F2 hybrids (J1 and J2) showed different hearing loss traits, with J1 mice presenting a retinitis pigmentosa phenotype and significant gene
MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia.
Stem Cell Reports
August 2016
Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address:
Degenerative cartilage endplate (CEP) shows decreased chondrification and increased ossification. Cartilage endplate stem cells (CESCs), with the capacity for chondro-osteogenic differentiation, are responsible for CEP restoration. CEP is avascular and hypoxic, while the physiological hypoxia is disrupted in the degenerated CEP.
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