Expression of HSP70 gene in rat brain after exposures to repeated +Gz.

Objective: To study the changes of mRNA expression of heat shock protein 70 (HSP70) in the rat brain exposed to repeated +Gz.

Method: The mRNA expression levels of HSP70 in rat brain were measured by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR).

Result: The HSP70 mRNA expression levels in rat brains taken 30 min and 6 h after repeated +Gz exposures were significantly higher than those in control group, while the difference between the levels of control group and those of experimental rat brains taken 24 h after +Gz exposure was not significant.

[Changes of mRNA expression of IL-1beta and TNF-alpha in rat brains after repeated exposures to +Gz].

Objective. To study changes of mRNA expression of IL-1beta and TNF-alpha in rat brains after repeated exposures to +Gz. Method.

[A control study of personality characteristics and variation of plasma peptide in pilots with neurosis].

Objective. To study the relationship between personality type and variation of plasma peptides in pilots with neurosis. Method.

[Cardiac arrhythmias in pilots under positive (+Gz) acceleration].

Objective: To study the relationship between cardiac arrhythmias and autonomic nervous regulation in pilots under +Gz acceleration.

Method: Dynamic ECG during +Gz exposures in 36 orthostatic intolerance pilots and 62 healthy pilots were analysed and compared.

Result: The orthostatic intolerance pilots had obviously lower +Gz tolerance and more cardiac arrhythmias.

[Analysis of time domain and frequency domain heart rate variability in fighter pilot before and after upright tilt].

Effects of upright tilt on mechanism of autonomic nervous regulation of cardiovascular system and characteristics of heart rate variability (HRV) were observed in sixty healthy male pilots. Relation between time domain and frequency domain indexes of short-time HRV (5 min) were analysed before and after upright tilt. The results showed that there are significant difference in short time HRV parameters before and after upright tilt.

[Assessment of responsiveness of spontaneous baroreceptor-heart rate reflex under gravitational stress].

Beat by beat arterial blood pressure was measured using Finapres 2300 monitor. Sequences of 3 or more beats with systolic pressure and next beat interval changed in the same direction were identified as baroreflex sequences from 6-min data segments. A linear regression was applied to each sequence and the slope (correlation coefficient > or = 0.

[Noninvasive evaluation of cardiovascular autonomic regulation and its application in physiological studies under weightlessness].

Recent progress in the noninvasive evaluation methods of cardiovascular autonomic regulation, including autonomic function tests, baroreflex function assessment, and heart rate, blood pressure variability analysis were discussed, and the results of applying these methods in physiological studies on head-down bed rest, head-up tilt, lower body negative pressure and aerobic training were reported. It suggests that noninvasive evaluation methods of cardiovascular autonomic regulation are effective means in weightlessness physiology study.

[Relation of GFR and endothelin in the plasma in pilots and ground crew].

Objective: To observe the specitic property of Glomeoular Filtration Rate (GFR) and its relation to endothelin of plasma in pilots.

Method: GFR was assessed with single photon emisson computed tomography (SPECT), tracer for 99mTc-DTPA, enthlion of plasma were measured by radio immunossay in forty-six pilots, thirty ground crew and renal disease patients.

Result: Endothelin were not correlation with GFR in pilots.

[Preliminary study on determination methods of respiratory muscle functions].

Attention has been paid to the research of respiratory muscle functions recently. In this paper some lung function indices concerning respiratory muscle functions, such as maximal inspiratory and expiratory pressure at mouth, inspiratory and expiratory tolerance time, transdiaphragmatic pressure and maximal transdiaphragmatic pressure and diaphragmatic electromyogram etc, were determined in 24 healthy young men and the normal values were obtained. They were important in the study of respiratory muscle functions in hard physical labours, especially in divers, pilots and sportsmen etc.

[Analysis of heart rate variability in Chinese healthy pilot].

Normal range of 24 h heart rate variability (HRV) and its application in healthy pilots of different age and sex were investigated. 24 h HRV data in 118 healthy male and female pilots and ground crew were measured. Comparing with male pilots, SDNN, HRVi, RMSSD, HF and ATP values in females are obviously higher (P < 0.

IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production.

Skin biopsies from healthy human skin and non-lesional skin from patients with psoriasis were cultured for 24 h and stimulated with interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma) in a skin organ culture model and the induction of the psoriasiform regenerative epidermal phenotype was analysed using immunostaining. In the presence of IL-1 beta, the psoriasiform regenerative epidermal phenotype was clearly induced. This involved strong up-regulation of the expression of keratin 16, keratin 17, and keratinocyte transglutaminase (TGk) in the suprabasal layers, strong up-regulation and a shift of the expression of keratin 5 and integrin beta 1 from the basal to suprabasal keratinocytes, and induction of the expression of ICAM-1 and HLA-DR on basal keratinocytes.

[The damped torsion swing test in guinea pigs].

The damped torsion swing test (DTST) was carried out for assessing the vestibular function in guinea pigs. Twenty guinea pigs which had normal pinna reflexes and normal tympanic membranes were used. In the formula, L represented the number of the left nystagmus, and R the right nystagmus during DTST.

A review of otolaryngologic aircrew disqualification in the Chinese Air Force, 1961-90.

Otolaryngologic disease was the third most common medical cause of permanent grounding, accounting for 145 (12.2%) of 1,186 aircrew members permanently grounded for various medical reasons in the General Hospital of the Chinese Air Force, 1961-90. We reviewed the medical files of these 145 grounded aircrew members.

Clinical application of tympanometry in aviators.

Tympanometry is a new procedure in determining the status of the middle ear and can be helpful in assessing the function of the eustachian tube. Of 274 male aviators examined, 174 were normal, 40 cases had acute aerotitis media, and 60 cases had chronic aerotitis media. Impedance audiometry and pure tone audiometry were carried out by means of an electroacoustic impedance bridge and audiometer, respectively.