Low doses of single or combined agrichemicals induces α-synuclein aggregation in nigrostriatal system of mice through inhibition of proteasomal and autophagic pathways.

Alpha synuclein (SNCA) genes and environmental factors are important risk factors of Parkinson's disease (PD). The agrichemicals paraquat, maneb and chlorpyrifos selectively target dopaminergic neurons, leading to parkinsonism, through ill-defined mechanisms. We analyzed the ability of low dose paraquat, maneb and chlorpyrifos, separately or combined together, to induce synucleinopathy in wild type mice.

14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/Akt/NF-кB signal transduction pathway.

14-3-3ζ protein, a member of 14-3-3 family, plays important roles in multiple cellular processes. Our previous study showed that 14-3-3ζ could bind to regulate the expression of hypoxia-inducible factor-1α (HIF-1α), which is induced by hypoxia and a crucial factor for induction of tumor metastasis. Moreover, we also have confirmed the response of 14-3-3ζ to hypoxia in our unpublished data as well.

Erythropoietin regulates Treg cells in asthma through TGFβ receptor signaling.

Asthma is a chronic inflammatory disorder of the airways, the development of which is suppressed by regulatory T cells (Treg). Erythropoietin (EPO) is originally defined as a hematopoietic growth factor. Recently, the anti-inflammatory effects of EPO in asthma have been acknowledged.