590 results match your criteria: "General Hospital of Shenyang Military Area Command; Shenyang-China. 13309884078@189.cn.[Affiliation]"

Bilirubin, the primary breakdown product of hemoproteins, particularly hemoglobin, plays a key role in the diagnosis, prognosis, and monitoring of liver diseases. In acute liver diseases, such as acute liver failure, drug-induced liver injury, and viral hepatitis, bilirubin serves as a biomarker reflecting the extent of hepatocyte loss and liver damage. Chronic liver diseases, including alcohol-related liver disease, chronic hepatitis C virus infection, metabolic dysfunction-associated fatty liver disease, and autoimmune liver diseases, are marked by persistent liver injury and inflammation.

View Article and Find Full Text PDF

Background: Intensive care unit (ICU) beds played a crucial role in reducing mortality rates of patients with severe COVID-19. The surge in the number of patients led to a shortage of ICU beds, which may have exacerbated inequity of healthcare utilization. However, most attention has been focused on the horizontal equity in healthcare utilization, where individuals with the same needs receive the same services.

View Article and Find Full Text PDF
Article Synopsis
  • Hypertension and type 2 diabetes contribute to an increased risk of premature death and related diseases, particularly affecting the same population.
  • An expert consensus using the GRADE approach was formed to create strategies aimed at reducing cardiovascular and kidney-related deaths while minimizing treatment burdens for adults with type 2 diabetes.
  • A multidisciplinary team developed 12 evidence-based recommendations focusing on screening, monitoring, lifestyle changes, and medication for individuals with type 2 diabetes, specifically addressing those who also have hypertension.
View Article and Find Full Text PDF
Article Synopsis
  • * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
  • * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
View Article and Find Full Text PDF

Construction and validation of a risk prediction model for soldiers with frostbite in northeast China: a cross-sectional study.

BMC Public Health

September 2024

Department of Nursing, General Hospital of Northern Theater Command, Wenhua Road 83rd Shenhe Region, Shenyang, Liaoning, 110016, People's Republic of China.

Article Synopsis
  • Study Purpose
  • : The research aimed to create and validate a risk prediction model for frostbite among soldiers training in extreme conditions in Northeast China, focusing on identifying risk factors for frostbite occurrence.
  • Methodology
  • : In winter 2021-2022, 698 soldiers were surveyed through a questionnaire; data were split into training and testing sets, and a Logistic regression analysis was used to establish the model for predicting frostbite risk based on various factors like temperature and wind speed.
  • Results
  • : Out of the training group, 19.83% suffered frostbite, primarily first-degree, with key risk factors identified. The model displayed strong predictive performance (AUC values of 0.816
View Article and Find Full Text PDF

The myth of the stigma of fatty liver: What does the evidence show?

Ann Hepatol

October 2024

Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico; Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico. Electronic address:

Recent efforts to reclassify non-alcoholic fatty liver disease (NAFLD) as metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) are intended to divert attention to the metabolic basis of the disease rather than to alcohol consumption. This reclassification recognizes the role of obesity, sedentary lifestyles and poor dietary habits in the development of the disease, leading to a better understanding of its etiology. Nevertheless, the transition has posed its own challenges, particularly with regard to communication between patient and healthcare professional.

View Article and Find Full Text PDF

Salts of weakly basic drugs can partially dissociate in formulations, to give basic drugs and counter acids. The aim of the present study was to clarify the effect of physicochemical properties on the basic drug-acid-polymer interactions and salt-polymer miscibility, and to explain the influence mechanism at the molecular level. Six maleate salts with different physicochemical properties were selected and PVA was used as the film forming material.

View Article and Find Full Text PDF

NAFLD-MASLD-MAFLD continuum: A swinging pendulum?

Ann Hepatol

August 2024

Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico; Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico. Electronic address:

View Article and Find Full Text PDF
Article Synopsis
  • Simethicone improves bowel preparation for colonoscopy, but the best timing of its intake prior to the procedure is still unclear.
  • A study involving 784 patients analyzed the effect of the timing of simethicone administration on bowel preparation quality using the Boston Bowel Preparation Scale.
  • Results indicated that a shorter time interval between taking simethicone and the start of colonoscopy is linked to better bowel preparation quality, highlighting the need to consider both timing and run-way time when preparing for the procedure.
View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the effectiveness and safety of different treatments for cancer treatment-induced thrombocytopenia (CTIT) in China, collecting data from over 1,600 patients across 33 hospitals.
  • Key findings indicate that recombinant thrombopoietin (rhTPO) was less effective in platelet recovery compared to recombinant interleukin 11 (rhIL-11), although both treatments provided similar outcomes overall.
  • The survey highlights that while there were no significant safety issues detected, many physicians preferred the thrombopoietin receptor agonist (TPO-RA) over the other treatment options.
View Article and Find Full Text PDF

Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium. It is characterized by acute onset, rapid progress and high risk of death. Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.

View Article and Find Full Text PDF

Stem cell therapy offers a promising avenue for advanced liver disease cases as an alternative to liver transplantation. Clinical studies are underway to explore the potential of stem cells from various sources in treating different liver diseases. However, due to the variability among current studies, further validation is needed to ensure the safety and effectiveness of stem cell therapy.

View Article and Find Full Text PDF

Global Burden of Cardiovascular Diseases and Risks, 1990-2022.

J Am Coll Cardiol

December 2023

Department of Health Metrics Sciences, Institute for Health Metrics and Evaluation, School of Medicine, University of Washington, Seattle, Washington, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address:

View Article and Find Full Text PDF

Rationale And Objectives: Hepatocellular carcinoma (HCC) treatment often requires transarterial chemoembolization (TACE). However, TACE efficacy is controversial in the presence of portal vein thrombosis (PVT). Although transarterial radioembolization (TARE) benefit was previously documented in PVT, neither the objective tumor response (OTR) after TARE with Iodine-131-lipiodol (I-lipiodol) nor the PVT effect on the results of locoregional therapies was accurately measured in prospective clinical trials.

View Article and Find Full Text PDF

GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism.

Free Radic Biol Med

January 2024

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China; Department of Neurology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Faculty of Life Sciences and Medicine, Northwest University, 710021, Xi'an, China. Electronic address:

Sepsis is a major health threat and often results in heart failure. Growth arrest-specific gene 6 (GAS6), a 75-kDa vitamin K-dependent protein, participates in immune regulation and inflammation through binding to AXL (the TAM receptor family). This study was designed to examine the myocardial regulatory role of GAS6 in sepsis.

View Article and Find Full Text PDF

Introduction: Bowel wall thickening is commonly observed in liver cirrhosis, but few studies have explored its impact on the long-term outcomes of patients with cirrhosis.

Methods: Overall, 118 patients with decompensated cirrhosis were retrospectively enrolled, in whom maximum wall thickness of small bowel, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum could be measured in computed tomography (CT) images. X-tile software was employed to determine the best cut-off values of each segment of bowel wall thickness for predicting the risk of further decompensation and death.

View Article and Find Full Text PDF

Development and Validation of a Post-Radiotherapy Prediction Model for Bowel Dysfunction After Rectal Cancer Resection.

Gastroenterology

December 2023

Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background & Aims: The benefit of radiotherapy for rectal cancer is based largely on a balance between a decrease in local recurrence and an increase in bowel dysfunction. Predicting postoperative disability is helpful for recovery plans and early intervention. We aimed to develop and validate a risk model to improve the prediction of major bowel dysfunction after restorative rectal cancer resection with neoadjuvant radiotherapy using perioperative features.

View Article and Find Full Text PDF
Article Synopsis
  • PRSS1 is a gene linked to chronic pancreatitis, and its variants can be difficult to classify due to differences in their effects on the enzyme's function.
  • The study analyzed 100 variants of the PRSS1 gene, categorizing them based on genetic impact and clinical significance using a new classification system.
  • Findings indicate that many PRSS1 variants can be classified as pathogenic, likely pathogenic, or benign, which could help improve how these variants are reported in medical databases.
View Article and Find Full Text PDF

Background: Due to disparities in medical resources in rural and urban areas as well as in different geographic regions in China, the effect of weekend versus weekday admission on the outcomes of acute ischemic stroke (AIS) patients is unknown. Our aim was to investigate whether the outcomes of AIS patients differ according to the day of admission in China.

Methods: The data were extracted from the Chinese Acute Ischemic Stroke Treatment Outcome Registry (CASTOR), a multicenter prospective study database of patients diagnosed with AIS.

View Article and Find Full Text PDF

Background: Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and inflammatory diseases. However, the molecular mechanism behind the differentiation, development and proliferation of SGs is far away to fully understand.

View Article and Find Full Text PDF

Metabolic dysfunction: The silenced connection with fatty liver disease.

Ann Hepatol

May 2024

Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico; Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) represents a global public health burden. Despite the increase in its prevalence, the disease has not received sufficient attention compared to the associated diseases such as diabetes mellitus and obesity. In 2020 it was proposed to rename NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD) in order to recognize the metabolic risk factors and the complex pathophysiological mechanisms associated with its development.

View Article and Find Full Text PDF