1 results match your criteria: "General Hospital of PLA Fifth Medical Center[Affiliation]"
[Exploration of the Role of Tumor Suppressor Genes Foxo1 and PTEN in the Tumorigenesis of Mouse Natural Killer-Cell Lymphoma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2019
Clinical College of 307 Hospital, PLA, Anhui Medical University; Hefei 230032, Anhui Province, China,Department of Lymphoma, General Hospital of PLA Fifth Medical Center, Beijing 100071,
Objective: To explore whether tumor suppressor gene Foxo1 and PTEN play a critical role in the tumorigenesis of mouse natural killer-cell lymphoma.
Methods: NKp46-iCre mice were crossed with mice carrying floxed Foxo1 alleles (Foxo1) as well as floxed PTEN alleles (PTEN) to generate mice in which Foxo1 and PTEN in NK cells were knock-out, referred as Foxo1PTEN. The growth and development of the mice and tumor formation were observed.