154 results match your criteria: "General Hospital of Chania[Affiliation]"

Background/objective: Primary Focal and Segmental glomerulosclerosis (FSGS) is one of the most common causes of idiopathic nephrotic syndrome. Our aim was to describe a large cohort of patients with primary FSGS, identify risk factors associated with worse renal survival and assess the impact of different immunosuppressive regiments on renal survival.

Methods: This was a historical cohort study of adults who were diagnosed with primary FSGS from March 26, 1982, to September 16, 2020.

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Aim: This study investigates the demographic distribution, antibiotic resistance profiles, and molecular characteristics of infections.

Methods: The study was carried out in 141 patients, 60.4% male, in patients from Chania and Heraklion, Crete.

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Dimensionality and psychometric properties of the Greek version of the Diabetes Impact and Device Satisfaction (DIDS) scale.

Psychiatriki

December 2024

Diabetes Center, 1st Propaedeutic Department of Internal Medicine, Medical School, "AHEPA" University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece.

Article Synopsis
  • Type 1 diabetes (T1D) is a growing chronic condition that requires insulin for management to avoid complications, and diabetes-related technology helps improve patients' daily living.
  • A study evaluated the Greek version of the Diabetes Impact and Device Satisfaction (DIDS) Scale, which measures how satisfied individuals are with their insulin delivery device and how diabetes affects their lives.
  • Results showed that the scale is reliable and valid, identifying three key factors: Device Satisfaction, Diabetes Management Impact, and Device Usability, with positive correlations to diabetes quality of life metrics.
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Bronchogenic cysts, first described in 1859, are rare congenital cystic malformations of the respiratory tract, with an incidence of one per 42,000-68,000 hospital admissions in one hospital series. They comprise 10-15% of mediastinal tumors and between 50% and 60% of mediastinal cystic lesions. Its clinical diagnosis is often challenging due to the absence of distinct imaging features.

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Introduction: The aim of this prospective study was to evaluate the impact of hemodialysis (HD) on myocardial injury, of both right and left ventricle function as well as their association with venous oxygen saturation (ScvO2) alterations.

Material And Methods: We included in the study stable consecutive patients with end-stage renal disease (ESRD) undergoing regular HD. Right and left ventricular speckle-tracking echocardiographies were performed in all patients.

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This study provides a comparative analysis of 243 Methicillin-resistant (MRSA) isolated strains from Greece and Romania, focusing on their epidemiology and antibiotic resistance patterns. Laboratory procedures included phenotypic and automated identification methods, susceptibility testing, DNA isolation, and PCR for detecting antibiotic resistance genes (, ). Our study results show significant regional differences.

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Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females. PCOS is associated with various metabolic and cardiovascular complications, including insulin resistance, dyslipidemia, and an increased risk of type 2 diabetes mellitus and cardiovascular disease. The role of serum prolactin (PRL) in the development of these complications in PCOS is not well understood.

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Background: Anaphylaxis proportions of incidence are increasing globally. However, limited data are available regarding anaphylaxis in the pediatric population of Greece.

Purpose: The aim of the study was to evaluate management of anaphylaxis in Greek pediatric departments.

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Article Synopsis
  • This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
  • Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
  • The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
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Prcis: There is evidence that cataract surgery can reduce intraocular pressure in patients with primary open angle, normal tension, or exfoliative glaucoma. The complete effect of phacoemulsification is masked by topical intraocular pressure-lowering medications.

Purpose: To assess the impact of phacoemulsification and intraocular lens implantation on intraocular pressure (IOP) level in individuals with primary open angle glaucoma (POAG), exfoliative glaucoma (XFG), exfoliation syndrome (XFS), normal tension glaucoma (NTG), ocular hypertension (OH), or healthy controls 12 months after the surgery.

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Article Synopsis
  • - The SUN4P project investigates stroke healthcare quality in Greece by analyzing patient data from nine hospitals for first-ever strokes between 2019-2021.
  • - Out of 892 patients studied, the majority had ischemic strokes, with only a small percentage receiving treatment in specialized acute stroke units; yet, a high percentage received follow-up medications upon discharge.
  • - This study marks the first comprehensive data collection on stroke care quality in Greece, aiming to enhance treatment standards and outcomes for stroke patients nationwide.
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Article Synopsis
  • Dose-dense sequential (dds) chemotherapy has positively impacted long-term survival rates in early breast cancer patients, as shown in the observational trial HE 10/10.
  • The study analyzed the role of tumor infiltrating lymphocytes (TILs) and CD8 lymphocytes in predicting outcomes, finding that higher levels are linked to better survival.
  • With a median follow-up of over 10 years, the study reported disease-free survival (DFS) at 78.4% and overall survival (OS) at 81.7%, highlighting the regimen's efficacy and safety.
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(1) Background: Chronic inflammation and suboptimal immune responses to vaccinations are considered to be aspects of immune dysregulation in patients that are undergoing dialysis. The present study aimed to evaluate immune responses in hemodialysis (HD) and online hemodiafiltration (OL-HDF) patients to a seasonal inactivated quadrivalent influenza vaccine (IQIV). (2) Methods: We enrolled 172 chronic dialysis patients (87 on HD and 85 on OL-HDF) and 18 control subjects without chronic kidney disease in a prospective, cross-sectional cohort study.

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Dimensionality and psychometric properties of the Parent Diabetes Distress Scale-Greek (PDDS-Gr).

Psychiatriki

October 2024

Diabetes Center, 1st Propaedeutic Department of Internal Medicine, Medical School, 'AHEPA' University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Macedonia.

Article Synopsis
  • * The study introduces the Greek translation of the Parent Diabetes Distress Scale (PDDS), which evaluates the emotional burden on parents of T1D children, highlighting key distress factors such as relationships and healthcare management.
  • * Findings indicate that the PDDS-Gr is a valid and reliable measure, with parents of children with poor blood sugar control reporting higher distress levels, confirming its usefulness for assessing diabetes-related stress in families.
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The Cost and the Value of Stroke Care in Greece: Results from the SUN4P Study.

Healthcare (Basel)

September 2023

Center for Health Services Management and Evaluation, Department of Nursing National and Kapodistrian, University of Athens, 115 27 Athens, Greece.

Article Synopsis
  • The study assessed the one-year total cost of strokes in Greece, focusing on patients with first-ever acute strokes admitted to hospitals within 48 hours of symptom onset.
  • It found that the total annual cost of stroke care was EUR 343.1 million in 2021, averaging EUR 10,722 per patient, with an estimated cost-effectiveness of EUR 23,308 per Quality Adjusted Life Year (QALY).
  • Key costs included 53.3% direct healthcare expenses and significant productivity losses, totaling EUR 160.2 million from work absences, premature retirement, and caregiving, emphasizing the need for improved stroke care and effective interventions.
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Cardiovascular disease (CVD) is a process whose pathogenetic mechanisms start very early in life. Recently, the importance of visceral adipose tissue (VAT) has been highlighted in the development of CVD. VAT does not always depend on body mass index (BMI) and has been implicated in unfavorable metabolic activity and cardiovascular adverse events.

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Article Synopsis
  • * In Greece, early restriction measures resulted in a milder Covid-19 surge, allowing for a study comparing stroke admissions before and during the pandemic.
  • * The study found no significant differences in stroke severity or patient characteristics between the two periods, but there was a notable delay in the time from symptom onset to CT scan during the pandemic (p=0.03).
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Introduction: The evaluation of myocardial contractility is essential in cardiology practice. The gold standard for this evaluation is the end-systolic elastance, but it the method involved is complex. Echocardiographic measurement of the ejection fraction (EF) is the most commonly used parameter in clinical practice, but it has significant limitations, especially in patients with afterload mismatch.

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is a pathogenic bacterium that causesinfections. Its virulence is due to surface components, proteins, virulence genes, , , , and , which are low molecular weight superantigens. are usually encoded by mobile genetic elements, and horizontal gene transfer accounts for their widespread presence in .

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The Inflammatory Bowel Disease-Disk Tool for Assessing Disability in Inflammatory Bowel Disease Patients: Validation of the Greek Version.

J Clin Med

April 2023

Department of Gastroenterology and Hepatology, 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University, 54124 Thessaloniki, Greece.

Background: The Inflammatory Bowel Disease-Disk (IBD-Disk) is a physician-administered tool that evaluates the functional status of patients with Inflammatory Bowel Disease (IBD). The aim of our study was to validate the content of the IBD-Disk in a Greek cohort of IBD patients.

Methods: Two questionnaires [the IBD Disk and the IBD-Disability Index (IBD-DI)] were translated into Greek and administered to IBD patients at baseline visit, after 4 weeks and 6 months.

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Aim: Assess the characteristics of break through COVID-19 in Inflammatory Bowel Disease (IBD) patients, despite complete vaccination.

Methods: Patients who reported a COVID-19 at least 3 weeks after complete vaccination were asked to answer an on-line anonymous questionnaire which included patient and disease characteristics, vaccination history, and the evolution of COVID-19.

Results: Among 3240 IBD patients who reported complete vaccination between 1st May 2021 and 30thJune 2022, 402 (12.

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Background: The way postpartum parents' COVID-19-related concerns are associated with the family environment, support resources and depressive symptoms areunder-investigated.

Methods: Two hundred and forty-three new parents (132 mothers, 111 fathers) completed self-report questionnaires within an 8-week period after birth. Parental concerns for COVID-19-related life changes were assessed with the COVID-19 Questionnaire, perceived social support with the Multidimensional Scale of Perceived Social Support, perceived family functioning with the Family Adaptability and Cohesion Evaluation Scales IV Package, dyadic coping behaviors with the Dyadic Coping Inventory and maternal/paternal postnatal depression with the Edinburgh Postnatal Depression Scale.

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Alport syndrome (AS) is the most frequent monogenic inherited glomerulopathy and is also genetically and clinically heterogeneous. It is caused by semi-dominant pathogenic variants in the X-linked (NM_000495.5) gene or recessive variants in the / (NM_000091.

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Dimensionality and psychometric properties of the Greek version of the Τype 1 Diabetes Stigma Assessment Scale (DSAS-1-Gr).

Psychiatriki

December 2023

Diabetes Center, 1st Propaedeutic Department of Internal Medicine, Medical School,'AHEPA' University General Hospital, Aristotle University of Thessaloniki, Thessaloniki,Macedonia.

Type 1 Diabetes Mellitus (T1D) is one of the most common chronic diseases affecting children and adolescents. The daily management of T1D requires continuous insulin therapy, as well as the inevitable adjustment of daily activities according to glycaemic control, both of which may result in experiencing T1D related stigma. A significant proportion of people with T1D have been shown to experience social discrimination and stigma, which can lead to emotional distress and act as a barrier to help-seeking behavior.

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Article Synopsis
  • A study investigated the role of CD8+ tumor-infiltrating lymphocytes (TILs) in early breast cancer patients who received adjuvant chemotherapy, revealing important prognostic implications based on their density in tumors.
  • Out of 928 patients, 627 had CD8+ data, with about 25% showing high levels of CD8 TILs, which were linked to more aggressive tumor characteristics and better survival rates.
  • High intratumoral (iCD8) and total (tCD8) counts were associated with longer disease-free survival (DFS) and overall survival (OS), indicating their potential as beneficial prognostic factors in managing early breast cancer.
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