Short Course of Systemic Steroids for Acute Respiratory Diseases During Infancy and Final Adult Height, Weight, and BMI: Preliminary Results from a Prospective Cohort Study.

Systemic corticosteroids are frequently used to manage acute respiratory diseases in infancy, but concerns about the long-term impacts on growth remain. This study aimed to evaluate the impact of short courses of systemic steroids administered exclusively during infancy on final adult height, weight, and BMI, adjusted by sex and cumulative steroid use. : A prospective cohort study was conducted including 257 participants (49.

"Nip and Tuck": Training the Next Generation of Aesthetic Plastic Surgeons.

The demand for aesthetic surgery continues to increase, and it is therefore essential to ensure that the next generation of plastic surgeons are adequately trained. We propose a safe method in aesthetic training in abdominoplasty and facelift, utilizing free deep inferior epigastric perforator (DIEP) flap and parotidectomy for training aesthetic procedures. The trainees' focus differed between the 2 procedures.

The Conservative Management of the Carpometacarpal Joint Fracture-Dislocation: A Case of the Second to the Fifth Ray.

Carpometacarpal (CMC) joint fractures-dislocations are rare due to the complex structure of the carpal bones and strong ligamentous support; while the clinical image is usually "noisy," they present significant management challenges due to the unstable nature of the injury. These injuries are typically caused by high-energy trauma and frequently result in dorsal dislocations. Treatment requires a careful balance between the immobilization and surgical restoration of the anatomical alignment to prevent complications.

Impact of C-FOS/C-JUN Transcriptional Factors Co-Expression in Non-small Cell Lung Carcinoma.

Background/aim: Significant transcription factors - including c-Fos (gene locus: 14q24.3) and c-Jun (gene locus: 1p32-p31) - regulate cell homeostasis preventing abnormal signal transduction to nucleus. Their over-activation seems to be associated with an aggressive phenotype in non-small cell lung carcinomas (NSCLCs).

Similar Hepatitis B virus reactivation risk for patients with inflammatory arthritis or connective tissue diseases: a multicenter retrospective study.

Introduction: Hepatitis B reactivation and administration of prophylactic antiviral treatment are considered in patients with autoimmune inflammatory rheumatic diseases (AIIRD) undergoing immunosuppressive/immunomodulatory treatment. Data are more robust for rheumatoid arthritis patients receiving bDMARDs but are limited for other AIIRD and drug categories.

Methods: Adult patients with AIIRD (inflammatory arthritis [IA] or connective tissue diseases [CTD]) and documented chronic or resolved HBV infection (defined as serum HBsAg positivity or anti-HBcAb positivity in the case of HBsAg non-detection respectively), followed-up in six rheumatology centers in Greece and Italy, were included.

Klippel-Trenaunay syndrome and chiari I malformation. A case report and systematic review of the literature.

Introduction: Klippel-Trenaunay Syndrome (KTS) is a rare congenital condition characterized by vascular malformations, bone abnormalities, and limb overgrowth. The genetic basis of KTS is not fully understood, and the diagnosis relies on clinical features. Its clinical spectrum includes several neurosurgical diagnoses, such as cavernous hemangiomas, arteriovenous fistulas, and Chiari I malformation.

The Use of Perpendicular Reconstruction Plates for the Buttressing of the Quadrilateral Surface Fractures of the Acetabulum: An Easy and Low-Cost Choice.

The quadrilateral surface fractures of the acetabulum are becoming more frequent due to the aging population. The optimal fixation of the quadrilateral surface through an appropriate surgical approach and a reliable and effective technique presents a challenge for orthopedic trauma surgeons. In this study, we present the results of 12 patients treated in our department who underwent internal fixation of the quadrilateral surface with two reconstruction plates in a vertical orientation for adequate fracture buttressing.

The Effect of Preoperative Information and Education on the Clinical Outcome of Total Hip Arthroplasty: A Prospective, Randomized Trial.

Introduction Preoperative patient information and education is an essential aspect of modern surgical care, particularly for patients undergoing total hip arthroplasty (THA). This prospective, randomized trial aimed to assess the effects of structured preoperative education and information on clinical outcomes in patients undergoing THA. Materials and methods A total of 102 patients were randomized into two groups: the intervention group (n = 51) receiving standardized preoperative information and education, and the control group (n = 51) receiving standard preoperative care without a formal educational component.

Fish Oil Consumption: Its Effects on Bone and Blood Parameters of the Ovariectomized Rat Model of Osteopenia.

: The beneficial effects of ω-3 fatty acids on the cardiovascular system have been observed in many epidemiological studies; however, their effects on the skeleton and in particular on postmenopausal bone loss appear to vary. The present study's purpose was to investigate the effects of oral fish oil (rich in ω-3 fatty acids) consumption on bone, plasma, and inflammation parameters in the ovariectomized (Ovx) rat model of osteopenia. : Four Groups of ten rats each were separated into Non-Ovx receiving fish oil (2.

Is fascia lata a viable graft for MPFL reconstruction? An overview of surgical technique and scoping literature review.

Lateral patellar dislocation is irrefutably one of the most common knee injuries, while subsequent medial patellofemoral ligament (MPFL) damage requires proper orthopedic care. Treatment of these injuries is regularly associated with the need for MPFL reconstruction surgery. This operation, often in combination with other procedures, can result very fruitful in restoring knee kinematics.

Respiratory Muscle Strength Correlation with Functional Capacity, Quality of Life, Demographics and Co-morbidities in Stroke and Spinal Cord Injury.

Objectives: To record Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP) in neuro-rehabilitation patients and establish correlation with functional status, quality of life, demographics and co-morbidities.

Methods: Respiratory muscle strength was measured in 50 stroke patients and 50 spinal cord injury (SCI) patients. Both groups were evaluated with the Modified Barthel Index (MBI-Shah version) and the 36-Item Short Form Survey.

Co-Occurrence of Two Rare Diseases: A Child with Phenylketonuria and WNT1 Osteoporosis.

Introduction: Phenylketonuria (PKU), an inborn error of metabolism, when inadequately treated, may lead to nutritional deficits, which could affect bone health. This remains a controversial issue, given that in the majority of PKU cases, bone mineral density is within normal limits. On the other hand, WNT1 mutations are detrimental for bone, as they lead to primary osteoporosis.

MPFL Reconstruction in Skeletally Immature Patients: Comparison Between Anatomic and Non-Anatomic Femoral Fixation-Systematic Review.

Background: MPFL reconstruction in children with open physis may be challenging, as a major concern during the surgery is to preserve the distal femoral physis. The purpose of this study was to compare the complication rate and the patient-reported outcomes in skeletally immature patients who underwent MPFL reconstruction using an anatomic (A) or non- anatomic (NA) surgical technique.

Methods: For this systematic review, the authors adhered to the PRISMA guidelines.

Increased specificity of the "GFAP/UCH-L1" mTBI rule-out test by age dependent cut-offs.

Objectives: Mild traumatic brain injury (mTBI) remains challenging to diagnose effectively in the emergency department. Abbott has developed the "GFAP/UCH-L1" mTBI test, to guide the clinical decision to perform a computed tomography (CT) head scan by ruling out the presence of mTBI. We evaluated the diagnostic accuracy of the "GFAP/UCH-L1" mTBI test in a Greek cohort and established age-dependent cut-offs.

The Impact of Rotational Malalignment Following Intramedullary Nailing for Intertrochanteric Fractures on Patients' Functional Outcomes: A Prospective Study.

: Rotational malalignment after intramedullary nailing of intertrochanteric fractures is a relatively common complication that may have a crucial impact on both functional outcome and a fracture's healing properties, ultimately affecting the patient's postoperative morbidity and mortality. : 74 patients treated with intramedullary nailing due to an intertrochanteric fracture underwent a postoperative computed tomography (CT) scan of the hips and knees. The femoral anteversion difference (D angle) between the operated and healthy hip was calculated using the technique described by Jeanmart et al.

Recommendations for European laboratories based on the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.

The 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for chronic kidney disease (CKD) evaluation and management bring important updates, particularly for European laboratories. These guidelines emphasize the need for harmonization in CKD testing, promoting the use of regional equations. In Europe, the European Kidney Function Consortium (EKFC) equation is particularly suited for European populations, particularly compared to the CKD-EPI 2021 race-free equation.

WITHDRAWN: A systematic review of therapies for aortobronchial fistulae.

The Publisher regrets that this article is an accidental duplication of an article that has already been published https://doi.org/10.1016/j.

Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response.

Patients with sepsis differ in their clinical presentations and immune dysregulation in response to infection, but the fundamental processes that determine this heterogeneity remain elusive. Here, we aim to understand which types of immune dysregulation characterize patients with sepsis. To that end, we investigate sepsis pathogenesis in the context of two transcriptional states: one represents the immune response to eliminate pathogens (resistance, R) and the other is associated with systemic inflammation (SI).

Advancing Diagnostic Techniques for Implant-Related Infections: the Synergistic Effect of Sonication and Dithiothreitol.

Purpose: Implant-related infections represent a significant complication contributing to increased morbidity and mortality. Determining the microbial agent causing the infection is crucial for successful treatment. Despite the incidence of periprosthetic joint infections (PJIs) rising over time, no diagnostic test with 100% sensitivity is available to identify these infections accurately.

Lumbar Spinal Rahisynthesis with Plif: a Retrospective Study of 58 Patients Demonstrating Imaging and Clinical Outcomes with One Year Follow-up.

Background/objectives: Nowadays, posterior lumbar cages remain a popular choice among the available options for interbody fusion even when compared with anterior approaches. As the posterior lumbar anatomy permits a relatively easy exposure to the spinal anatomy of interest, expandable cages prove to be a reliable tool for 360-degree fusion. Our study aspires to investigate the postoperative effects of Flarehawk 9 after open posterior lumbar fixation.

The Need for Standardization of Continuous Glucose Monitoring Performance Evaluation: An Opinion by the International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Continuous Glucose Monitoring.

Metrics derived from continuous glucose monitoring (CGM) systems are often discordant between systems. A major cause is that CGM systems are not standardized; they use various algorithms and calibration methods, leading to discordant CGM readings across systems. This discordance can be addressed by standardizing CGM performance assessments: If manufacturers aim their CGM systems at the same target, then CGM readings will align across systems.

Penetrating Femoral Trauma: A Report on Its Management and Outcome.

Penetrating trauma of the femur poses significant life-threatening risks due to potential complications, particularly involving the femoral structures such as the femoral artery, femoral vein, and femoral nerve. These injuries can lead to severe outcomes, especially when accompanied by soft tissue damage. Effective management requires a thorough understanding of the injury's nature, including the extent of soft tissue involvement and associated complications.