Analysis of minerals and phytochemicals in the leaves of the plant using spectroscopic methods and screening of antibacterial activity.

This study presents an innovative X-ray diffraction (XRD) application to identify minerals in the medicinal plant . Additionally, this study includes the analysis of chemical compounds and screening antibacterial activity in the leaf extract, using Gas Chromatography-Mass Spectrometry (GC-MS) and UV-visible spectroscopy. The results of X-ray diffraction showed that the leaves are a rich source of minerals such as oxides of Potassium, Magnesium, and Calcium.

Design, Synthesis of Flurbiprofen Based 1,3,4-Oxadiazoles and Constrained Anticancer, Antioxidant Agents: In silico Docking Analysis.

Flurbiprofen, a primary component of a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis, and is a considerable interest in medicinal chemistry due to its demonstrated potential as an effective agent in various therapeutic applications. In consideration of the 1,3,4-oxadiazole therapeutic potential and anticancer activity, a new series of flurbiprofen scaffolds have been prepared through a straightforward reaction between 5-(1-(2-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-1,3,4-oxadiazole-2-thiol (4) and various organic active 2-chloro-N-phenyl acetamides (5). The synthesized series (6a-6k) was characterized using a combination of spectroscopic techniques, including FT-IR, mass, H-NMR, and C NMR, followed by physical data.

New Chalcone Incorporated Structurally Modified Pyridine-Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in-vitro Evaluation.

Chalcone-incorporated pyridine-pyrimidines i.e. derivatives of (5-(6-(pyrimidin-5-yl)pyridin-3-yl)thiophen-2-yl)prop-2-en-1-one were synthesized and their structures were confirmed by analytical techniques.

Design, Synthesis and In vitro Antitubercular Effect of New Chalcone Derivatives Coupled with 1,2,3-Triazoles: A Computational Docking Techniques.

A very interesting foundation for this study is the creation of new methods for modifying compounds with a 1,2,3-triazole and chalcone scaffolds, as these compounds are significant in organic synthesis, particularly in the synthesis of bioactive organic compounds. To contribute to the development of an efficient method for the conversion of antimicrobial and antituberculosis heterocyclics, a novel series of cyclohepta pyridinone fused 1,2,3-triazolyl chalcones were designed and synthesized. All the newly prepared scaffolds were characterized by FT-IR, NMR (H & C) and mass spectrometry.

A novel optimized neural network model for cyber attack detection using enhanced whale optimization algorithm.

Cybersecurity is critical in today's digitally linked and networked society. There is no way to overestimate the importance of cyber security as technology develops and becomes more pervasive in our daily lives. Cybersecurity is essential to people's protection.

Design, Synthesis of Novel 1,2,3-Triazole Pendent Quinazolinones and Their Cytotoxicity against MCF-7 Cell Line.

A library of 6-(((1-(substitutedphenyl)-1H-1,2,3-triazol-4-yl)methyl) amino)-3-methylquinazolin-4(3H)-one analogues synthesized from Isatin precursor through a series of nitration, reduction, hydrolysis, cyclization and click reaction. The structures of compounds were characterized by spectral data including IR, H-NMR, C NMR and Mass. The novel quinazolinone - 1,2,3-triazoles were screened for their cytotoxicity against the human breast adenocarcinoma cell lines MCF-7 by MTT assay.

Simultaneous S-scheme promoted Ag@AgVO/g-CN/CeVO heterojunction with enhanced charge separation and photo redox ability towards solar photocatalysis.

Photocatalytic removal of toxic contaminants is one of the emerging techniques for water remediation, but it suffers from low redox ability, charge recombination and poor light harvesting efficiency. The present work reports a simultaneous S-scheme promoted by CeVO/g-CN/Ag@AgVO. The formation of the S-scheme mechanism enhanced the generation of photogenerated carriers and also improved the redox ability of the electrons and holes in the reduction and oxidation photocatalysts.

Deep convolutional neural network with sine cosine algorithm based wastewater treatment systems.

Wastewater treatment systems are essential in today's business to meet the ever-increasing requirements of environmental regulations while also limiting the environmental impact of the sector's discharges. A new control and management information system is needed to handle the residual fluids. This study advises that Wastewater Treatment System (WWTS) operators use intelligent technologies that analyze data and forecast the future behaviour of processes.

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents.

Background: 1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory, analgesic, diabetic, immunosuppressive, α,β-receptor antagonist, antimicrobial, anti-helminthic, histamine-H3 and antiparasitic properties. A pyrimidine analog, 5 fluoro-uracil is a chemotherapeutic drug used for treating multiple solid malignant tumors.

Relaxation dynamics of l-alanine in water medium investigated by dielectric relaxation spectroscopy.

The complex dielectric permittivity of L-alanine in aqueous medium at different concentrations and different temperatures were measured in the microwave (0.02 < ν/GHz < 20) frequency region by using open-ended coaxial probe technique. From the reflection coefficient and impedance data, the real and imaginary part of the dielectric permittivity values is determined.

Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives.

Background: The intensely increasing multi-drug resistant microbial infections have encouraged the search for new antimicrobial agents. Hydrazone derivatives are known to exhibit a wide variety of biological activities including anti-microbial. In heterocyclic moiety, imidazo[1,2-a]pyrimidines are the subject of immense interest for their antimicrobial activity and also for their analgesic, antipyretic and anti-inflammatory properties.