Oligogenic risk score for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders.

Gilles de la Tourette syndrome (GTS) and other tic disorders (TDs) have a substantial genetic component with their heritability estimated at between 60 and 80%. Here we propose an oligogenic risk score of TDs using whole-genome sequencing (WGS) data from a group of Polish GTS patients, their families, and control samples (n = 278). In this study, we first reviewed the literature to obtain a preliminary list of 84 GTS/TD candidate genes.

The effects of mobile phone addiction on learning engagement of Chinese college students - the mediating role of physical activity and academic self-efficacy.

Background: With the widespread adoption of smartphones, mobile phone addiction has increasingly gained prominence among Chinese college students, exerting a profound and detrimental impact on their learning engagement. This study employs self-determination theory as a framework to examine the mechanisms through which mobile phone addiction affects students' learning engagement. Specifically, it examines the mediating effects of physical activity and academic self-efficacy in this relationship.

A Systematic Review and Meta-Analysis of Asian Exercise Techniques and Various Physical Activity Interventions in Middle and Late Adulthood Patients With Knee Osteoarthritis.

Objectives: The aim of this review and meta-analysis is to compare different low-intensity forms of physical activity (PA; Baduanjin, Tai Chi, walking, and general PA) as treatments for knee osteoarthritis.

Methods: Between 2003 and 2023, pertinent articles published in scientific electronic databases (PubMed, Web of Science, EBSCOhost, and Google Scholar) were searched in preparation for a systematic review and meta-analysis. Twenty-four studies that satisfied the requirements were selected, with a total sample size of 1,972 participants, of which 71.

Measurement Properties of Wearable Kinematic-Based Data Collection Systems to Evaluate Ball Kicking in Soccer: A Systematic Review with Evidence Gap Map.

Kinematic assessment of ball kicking may require significant human effort (e.g., traditional vision-based tracking systems).

Systematic Review of , , , , , and Gene Polymorphisms and Meta-Analysis of Variant and Its Association with Overweight and Obesity Risk in Men.

Obesity is a complex health risk influenced by genetic, environmental, and lifestyle factors. This review systematically assessed the association between interleukin gene polymorphisms (rs16944, rs17561, rs1143623, rs1143633, rs1143634, rs1800587, rs2234677, and rs4848306), (rs180275, rs1805010, rs13306435, rs1800795, rs1800796, rs1800797, rs2228145, rs2228145, rs2229238, and rs4845623), (rs1518110, rs1518111, rs1800871, rs1800872, rs1800896, rs1878672, rs2834167, rs3024491, rs3024496, rs3024498, and rs3024505), (rs3136617, rs3136618, and rs2296135), and (rs187238, rs1946518, rs2272127, rs2293225, and rs7559479) and the risk of overweight and obesity in adults, focusing on rs1800795 through a meta-analysis. The focus on in this review arises from its pleiotropic nature and unclear effect on obesity risk.

The Effect of EEG Biofeedback Training Frequency and Environmental Conditions on Simple and Complex Reaction Times.

The objective of this study is to evaluate the impact of EEG biofeedback training under normoxic and normobaric hypoxic conditions on both simple and complex reaction times in judo athletes, and to identify the optimal training frequency and environmental conditions that substantially enhance reaction times in the examined athlete groups. The study comprised 20 male judo athlete members of the Polish national judo team in the middleweight and heavyweight categories. We randomly assigned participants to an experimental group and a control group.

Can motor competence be influenced by the type of training interventions preschool children are exposed to? A randomized experimental study comparing sports games and psychomotricity activities.

Introduction: This study aimed to compare the effects of structured sports games (SG) and psychomotricity activities (PCM) on the locomotor, stability, and manipulative motor competencies of preschool children.

Methods: A randomized controlled trial was conducted over an 8-week period, involving two experimental groups (SG, = 30 and PCM, = 30) and one control group (CG, = 28), with participants attending two intervention sessions per week. A total of 88 5-year-old children participated in the experiment (boys = 48; girls = 40).

Enhancing physical fitness using recreational soccer and basketball: A parallel-controlled 8-week study involving overweight and obese individuals, with consideration of sex-related interactions.

The purpose of this study was to examine the effects of 8-week intervention of recreational soccer (SCG) and basketball (BCG) conditioned games, as compared to self-exercise (SECG) and inactive (ICG) control groups, on aerobic capacity, vertical (VJ) and horizontal jump (SLJ) performance, and handgrip maximal strength (HG) in sedentary overweight and obese men and women. Ninety male and female sedentary overweight and obese volunteers (19.8 ± 1.

Effects of 6 weeks of complex training on athletic performance and post-activation performance enhancement effect magnitude in soccer players: a cross-sectional randomized study.

This study aimed to determine the effect of complex training (CT) on post-activation performance enhancement (PAPE) effect magnitude, 5- and 30-m linear sprint, 5-0-5 change-of-direction (COD), back squat (BS) and hip thrust (HT) one-repetition maximum [1RM], and jumping performance (countermovement jump [CMJ], drop jump [DJ], and broad jump [BJ]). The PAPE effect was elicited before and after each intervention by 3 BS repetitions at 90% 1RM and verified by CMJ performance. Twenty-four soccer players were randomly and equally assigned to 6 weeks of either medium (MED; [65-70%1RM]) or high-intensity (HIGH; [80-85%1RM]) CT performed twice a week.

Relationship between middle school students' academic stress and physical exercise behavior from the perspective of Self-Determination Theory: The chained mediation of motivation and intention.

Academic stress is associated with lower engagement in healthy behaviors, including physical exercise, among middle school students. Based on Self-Determination Theory, this study examines the association between academic stress and physical exercise behavior among middle school students, exploring the mechanisms through the chained mediation of motivation and intention. Scales used in this study include the Academic Stress Scale, Autonomous and Controlled Motivation Scales, and Physical Exercise Intention and Behavior Scales to measure relevant variables.

Acute effects of supramaximal loaded back squat activation on countermovement jump performance, muscle mechanical properties, and skin surface temperature in powerlifters.

This study aimed to investigate the effects of performing either eccentric-only (ECC) or eccentric-concentric (ECC-CON) back squats (BS) with a supramaximal load on countermovement jump (CMJ) performance. Changes in front thigh skin surface temperature and mechanical properties (oscillation frequency and stiffness) of the vastus lateralis were also examined. Fourteen male powerlifters participated in this study (age: 22.

Effect Analysis of Early Rehabilitation Therapy Combined with Repetitive Transcranial Magnetic Stimulation on Postoperative Rehabilitation of Sports Knee Injury.

Objective: To analyze the effectiveness of combined early rehabilitation therapy and repetitive transcranial magnetic stimulation (rTMS) in the postoperative rehabilitation of patients with sports knee injuries (SKI).

Methods: A total of 62 SKI patients from June 2021 to June 2022 were randomly selected by computer and divided into group A (31 cases, early rehabilitation therapy) and group B (31 cases, early rehabilitation therapy +rTMS) by numbered envelope method. The effects of the two groups were compared.

Diurnal Variations in Upper and Lower Body Power in Adolescent Volleyball Players: Exploring Time-of-Day Effects on Performance.

Background/objectives: This study aims to investigate the daily variations in upper and lower body power performance in adolescent volleyball players.

Methods: The sample consisted of 50 young male volleyball players (14.12 ± 0.

RELATIONSHIP OF THE PERCEIVED STRESS LEVEL, ANTHROPOMETRIC INDICATORS AND BODY COMPOSITION IN CHILDREN EXPERIENCING PERMANENT NEGATIVE IMPACT OF THE COVID-19 PANDEMIC AND THE WAR IN UKRAINE.

Objective: to assess the impact of stressful life events occuring with the period of restrictive measures introductionconnected to the COVID-19 pandemic and during the full-scale Russian aggression, on the anthropometric indicators and body composition of children aged 10-17 years.

Materials And Methods: The research group consisted of 56 boys and 70 girls aged 10-17 years who lived in radioactively contaminated areas of Zhytomyr, Rivne, and Kyiv regions with a soil contamination density of 137Cs from 18 kBq/m2 to 235 kBq/m2. The impact of stressful factors was assessed using the stress perception scale (PSS-10).

Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis.

Background: Inflammation can result in the development of breast cancer in women with overweight and obese, and also affects the outcome and prognosis of breast cancer patients, thereby decreasing the cure and survival rates of breast cancer patients. Exercise may benefit breast cancer patients as a supplement to conventional treatments. However, research on the effects of exercise on inflammatory markers in women with breast cancer who are overweight and obese remains incomplete.

Revealing induced pluripotent stem cells' potential as a better alternative to embryonic stem cells for Parkinson's disease treatment based on single-cell RNA-seq.

Both embryonic stem cells (ESCs) and the successful reprogramming of induced pluripotent stem cells (iPSCs) offer an unprecedented therapeutic potential for Parkinson's disease (PD), allowing for the replacement of depleted neurons in PD-affected brain regions, thereby achieving therapeutic goals. This study explored the differences in cell types between iPSCs and ESCs in the PD brain to provide a feasible theoretical basis for the improved use of iPSCs as a replacement for ESCs in treating PD. Signal cell RNA sequencing data and microarray data of ESCs and iPSCs were collected from the GEO database.

Immediate Effect of Compression Contrast Therapy on Quadriceps Femoris Muscles' Regeneration in MMA Fighters.

This study aimed to evaluate the immediate effect of Game Ready (GR) heat-cold compression contrast therapy (HCCT) on changes in the biomechanical parameters of the quadriceps femoris muscles and tissue perfusion. Fifteen male MMA fighters were subjected to HCCT on the dominant leg's thigh and control sham therapy on the other. The experimental intervention used a pressure cuff with the following parameters: time-20 min; pressure-25-75 mmHg; and temp.

Adverse Reactions to Dry Needling Therapy: Insights from Polish Physiotherapy Practice.

: The current study aimed to characterize the adverse reactions associated with dry needling (DN) treatments reported by Polish physiotherapists, with a secondary objective of investigating whether the level of DN experience influences the occurrence of these adverse effects. : A total of 102 Polish physiotherapists, all with regular DN practice, participated in an ad hoc online survey. The participants were categorized by their level of experience in DN treatment: 44 with 0-2 years, 43 with 3-6 years, and 15 with more than 7 years of experience.

Barriers and Facilitators of Physical Activity in Pregnancy and Postpartum Among Iranian Women: A Scoping Review.

Inactivity during pregnancy and postpartum is largely a result of women's attitudes and misunderstandings of physical activity, especially in Iran. This scoping review critically assesses the barriers and facilitators influencing physical activity among pregnant and postpartum Iranian women to provide the basis for future physical activity interventions. Ten databases and platforms were searched up to 1 June 2024: Medline, SportDISCUS, PsycINFO, EMBASE, CINAHL, Cochrane Review Database, Clinical Trial, SID, ISC, and Web of Science.

Genetic Determinants of Endurance: A Narrative Review on Elite Athlete Status and Performance.

This narrative review explores the relationship between genetics and elite endurance athletes, summarizes the current literature, highlights some novel findings, and provides a physiological basis for understanding the mechanistic effects of genetics in sport. Key genetic markers include R577X (muscle fiber composition), I/D (cardiovascular efficiency), and polymorphisms in , , and , influencing energy metabolism, angiogenesis, and cardiovascular function. This review underscores the benefits of a multi-omics approach to better understand the complex interactions between genetic polymorphisms and physiological traits.

Omega-3 Fatty Acids and Muscle Strength-Current State of Knowledge and Future Perspectives.

Omega-3 polyunsaturated fatty acids (-3 PUFAs), specifically the most biologically active (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), have well-documented health-promoting effects, including, but not limited to, controlling inflammatory processes in the human body and supporting cardiovascular and cognitive health and visual processes. There is also some evidence pointing to the potential of EPA and DHA to preserve and/or enhance muscle strength. Muscle strength plays a crucial role in preventing age-related decline in skeletal muscle mass and function and the subsequent impaired functionality in the daily lives of the elderly.

Effects of high-intensity interval training on lipid metabolism, tumor necrosis factor-α, and C-reactive proteinin overweight children.

Objective: To investigate the effects of high-intensity interval training on lipid metabolism and inflammatory factors in overweight children, and provide clinical guidance and recommendations for children's weight management.

Methods: A retrospective study was conducted to analyze 60 overweight children, who were randomly divided into an experimental group (high-intensity interval training) and a control group (health education as intervention). Baseline data, physical indicators, and biochemical indicators were analyzed.

An Educational Review on Machine Learning: A SWOT Analysis for Implementing Machine Learning Techniques in Football.

Purpose: The abundance of data in football presents both opportunities and challenges for decision making. Consequently, this review has 2 primary objectives: first, to provide practitioners with a concise overview of the characteristics of machine-learning (ML) analysis, and, second, to conduct a strengths, weaknesses, opportunities, and threats (SWOT) analysis regarding the implementation of ML techniques in professional football clubs. This review explains the difference between artificial intelligence and ML and the difference between ML and statistical analysis.

Linear and Multidirectional Speed Testing (On-Field and Off-Field) Protocols in Senior and Elite Female Football.

Beato, M, Datson, N, Clemente, FM, Harper, DJ, Fílter, A, Emmonds, S, Dos' Santos, T, and Jones, PA. Linear and multidirectional speed testing (on-field and off-field) protocols in senior and elite female football. J Strength Cond Res 39(1): e70-e84, 2025-Female football has had a considerable rise in popularity with millions of fans after matches during the recent Women's World Cup.