Novel Tricyclo[4.2.1]Nonane and Bicyclo[2.2.1]Heptane Derivatives: Synthesis, in Vitro Biological Activities and in Silico Studies.

The target benzothiazole derivatives (8a-g) were synthesized starting from norbornene. The addition of dichloroketene to norbornene followed by the reduction of chlorine atoms were synthesized tricyclo[4.2.

Effect of Health Literacy and Patient Activation on Health-Seeking Behaviour: A Cross-Sectional Study in Turkey.

Background: The study aimed to investigate the effect of health literacy and patient activation on health-seeking behaviour. In addition, the role of general health status and age variables in this effect was also addressed.

Methods: The research using quantitative methods is cross-sectional.

The Relationship between D'Amico and ISUP Risk Classifications and Ga-PSMA PET/CT SUVmax Values in Newly Diagnosed Prostate Cancers.

Introduction: This study aimed to evaluate the relationship between pathological and clinical risk classifications in newly diagnosed prostate cancer patients, and Ga-PSMA PET/CT data and serum Prostate Specific Antigen (PSA) values.

Method: A total of 203 patients who were diagnosed with prostate cancer between 2019 and 2023, who had not yet received treatment and who underwent Ga-PSMA PET/CT for staging purposes were included in this study.

Results: There was a substantial correlation between D'Amico risk classification, Gleason score, ISUP classification, and the presence or absence of metastasis ( < 0.

The Interactions of Resveratrol and Sodium Valproate on Penicillin-Induced Epilepsy Model: Electrophysiological and Molecular Study.

Epilepsy represents the most prevalent chronic neurological disease, characterized by spontaneous recurrent seizures. In experimental epilepsy models created by different methods, resveratrol has been demonstrated to reduce epileptiform activity and exhibit neuroprotective properties. A penicillin-induced model of epileptogenesis was used to investigate the effects of resveratrol and its combination with sodium valproate on epileptiform activity.

Antimoniosis: Radiological Insights into a Rare Pneumoconiosis in Miners.

Aim: Pneumoconiosis describes diseases caused by the accumulation of inorganic dust particles in the lungs, leading to tissue damage. The diagnosis relies on a history of exposure and compatible radiological findings.

Background: We aimed to investigate the radiological findings in individuals exposed to antimony-inert dust relative to their working periods.

Corrigendum to "Polybrominated methoxy- and hydroxynaphthalenes" [Turkish Journal of Chemistry 40 (2) 2016 332-346 ].

[This corrects the article on p. 332 in vol. 40.

The Enhancing of Nurses' and Midwives' Competence in Providing Spiritual Care through Innovative Education and Compassionate Care using the Spiritual Care Competency Self-Assessment Tool: Turkish Version.

Spiritual care is an important part of holistic care and is at the center of nursing/midwifery care. Nurses/midwives are expected to graduate by receiving adequate training in spiritual care and gaining spiritual care competence during their student days. It is important to evaluate the spiritual care competencies of nursing/midwifery students and to correct the deficiencies, if any.

The Impact of Triglyceride-Glucose Index Levels During Perioperative Period on Outcomes in Femoral Neck Fracture Patients.

Introduction: The objective of the present study is to assess the impact of the triglyceride-glucose index (TyG index) on the prognosis and explore the correlation between the TyG index and all-cause mortality in femoral neck fracture patients.

Materials And Methods: In this retrospective cohort study, we analyzed the TyG index in the follow-up of femoral neck fracture patients who underwent partial hip prosthesis. The formula of ln [fasting triglycerides (mg/dL) x fasting blood glucose concentration (mg/dL)/2] was used in the calculation of the TyG index.

The effect of lavender oil use on pain and comfort level in intramuscular injection administration: A single blind randomized controlled study.

Context: The fact that the concept of quality in health care services has come to the fore and that evidence-based practices have become widespread made such concepts as patient satisfaction and comfort important and priority parameters in determining the quality of health services.

Objectives: The aim of the study is to determine the effects of using lavender oil in intramuscular injection on injection pain, comfort level, blood pressure, pulse rate and respiratory rate.

Methods: The study was designed as a prospective, single-blind randomized controlled trial.

The Effect of Mask Use on Seasonal Virus Diversity in SARS CoV-2 Negative Patients Treated as Inpatients During the 2021-2022 and 2022-2023 Seasonal Flu Period.

The study aimed to explore the protective effect of mask use against respiratory tract viral agents during the pandemic. The study included patients with a COVID-19 negative test who were hospitalized in the pulmonary disease clinic with the diagnoses of asthma attack, chronic obstructive pulmonary disease (COPD) exacerbation, and pneumonia in two periods: during mandatory mask use (October 2021 - May 2022) and after the mask mandate was lifted (October 2022 - May 2023). Combined nose and throat swab samples taken from the patients were evaluated for viral agents by using the PCR test method.

Ultrasound-assisted dispersive micro solid phase extraction of maneb in water and food samples with new hybrid block copolymer material prior to micro-spectrophotometric analysis.

A simple and effective ultrasound-assisted dispersive micro solid-phase extraction (UA-dμSPE) method was developed for the spectrophotometric determination of traces maneb in food and water. In this study, a new hybrid block copolymer poly (vinyl benzyl chloride-b-dimethyl aminoethyl methacrylate) (Pvb-DMA) was synthesized and characterized using techniques such as FTIR, SEM-EDX. The synthesized Pvb-DMA was used as an adsorbent for the extraction of maneb for first time in this study.

Investigation of the effects of melatonin application on storage in plums (Prunus domestica L.) grown under organic and conventional conditions.

This study was carried out to investigate the effects of melatonin applications on postharvest quality changes of organic and conventionally grown plum fruit. Melatonin was applied in 0, 50, and 100 µmol L for organic and conventional samples. The fruits were stored at + 2.

Predictive effect of insomnia on quality of life in last trimester pregnant women: A cross-sectional study.

This study was conducted to determine the predictive effect of insomnia on quality of life in last trimester pregnant women. This study is a cross-sectional study. The sample of the study consisted of 309 women who were pregnant in the last trimester and were followed up in the university hospital.

A short stature allele enhances tolerance to zinc deficiency and translocation of zinc in barley.

Background: Zinc (Zn) content is of great importance in healthy human diet, crop productivity and stress tolerance in soils with zinc deficiency. The genes used to increase yield per unit area such as semi-dwarf 1 () is commonly considered to reduce mineral content of grain.

Methods: In the present study, influence of , a widely used allele for short plant height in barley breeding, on zinc accumulation and tolerance to zinc deficiency were investigated.

Potentiometric determination of the local anesthetic procaine in pharmaceutical samples.

In this study, a new potentiometric sensor was developed for the determination of the local anesthetic drug procaine in pharmaceutical samples. Procaine (Pr)-Tetraphenlyborate (TPB) ion-pair was synthesized and used as a sensor material. Potentiometric sensors using the synthesized ion pair (Pr-TPB), poly(vinyl chloride) (PVC) and o-nitrophenyloctyl ether (o-NPOE) in different proportions were prepared and their performance properties were tested.

Genetic Polymorphisms of COL1A1 Promoter Region (rs1800012) and TGFB1 Signal Peptide (rs1800471): Role in Cervical Insufficiency Susceptibility?

A structural or functional cervix problem prevents a woman from carrying a full-term pregnancy, which leads to the disease known as cervical insufficiency. Cervical insufficiency is partially inherited, and in certain situations, variations in genes related to connective tissue metabolism may be involved. The main objective of this investigation was to describe the collagen type I alpha 1 chain (COL1A1) gene rs1800012 polymorphism and the transforming growth factor beta 1 (TGFB1) gene rs1800471 polymorphism in a cohort of patients suffering from cervical insufficiency.

A Mediation Model of Food Literacy: A Potential Relationship between Body Image Dissatisfaction and Body Mass Index.

: The global rise in obesity presents a significant public health challenge, with Turkey exhibiting one of the highest obesity rates in Europe. Body image dissatisfaction (BID) and lower food literacy (FL) have been associated with obesity, yet their interplay remains underexplored. This study aimed to investigate the relationship between body mass index (BMI), body image dissatisfaction, and FL in adults in Turkey.

Testicular mosaicism in non-mosaic postpubertal Klinefelter patients with focal spermatogenesis and in non-mosaic prepubertal Klinefelter boys.

Study Question: Do testis-specific cells have a normal karyotype in non-mosaic postpubertal Klinefelter syndrome (KS) patients with focal spermatogenesis and in non-mosaic prepubertal KS boys?

Summary Answer: Spermatogonia have a 46, XY karyotype, and Sertoli cells surrounding these spermatogonia in postpubertal patients also have a 46, XY karyotype, whereas, in prepubertal KS boys, Sertoli cells surrounding the spermatogonia still have a 47, XXY karyotype.

What Is Known Already: A significant proportion of patients with non-mosaic KS can have children by using assisted reproductive techniques thanks to focal spermatogenesis. However, the karyotype of the cells that are able to support focal spermatogenesis has not been revealed.

A majority of circadian clock genes are expressed in estrogen receptor and progesterone receptor status-dependent manner in breast cancer.

Circadian clocks, biochemical oscillators that are regulated by environmental time cues including the day/night cycle, have a central function in the majority of biological processes. The disruption of the circadian clock can alter breast biology negatively and may promote the development of breast tumors. The expression status of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) were used to classify breast cancer into different molecular subtypes such as triple-negative breast cancer (TNBC).

Saving lives and restoring hope: Enhancing outcomes through comprehensive understanding of maxillofacial surgery in disaster medicine.

This article delves into the profound impact of various types of disasters, examining some specific contexts. It provides insights into the unique challenges posed by different disasters, ultimately highlighting the invaluable role of maxillofacial surgery in addressing the critical healthcare needs of affected populations. A comprehensive review of the literature was conducted to analyze the role of maxillofacial surgery in disaster management.