Dystonia caused by ANO3 variants is due to attenuated Ca influx by ORAI1.

Background: Dystonia is a common neurological hyperkinetic movement disorder that can be caused by mutations in anoctamin 3 (ANO3, TMEM16C), a phospholipid scramblase and ion channel. We previously reported patients that were heterozygous for the ANO3 variants S651N, V561L, A599D and S651N, which cause dystonia by unknown mechanisms.

Methods: We applied electrophysiology, Ca measurements and cell biological methods to analyze the molecular mechanisms that lead to aberrant intracellular Ca signals and defective activation of K channels in patients heterozygous for the ANO3 variants.

Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage.

Ischemia-reperfusion (I/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO) affects systemic anti-inflammatory response and inflammation.

Effects of Manual Therapy and Home Exercise Treatment on Pain, Stress, Sleep, and Life Quality in Patients with Bruxism: A Randomized Clinical Trial.

: This study aimed to examine the effects of manual therapy (MT) and home exercise (HE) treatments on pain, sleep quality, stress level, and quality of life in patients with bruxism. : The study included 30 bruxism patients ages 18-25 years who were randomly divided into the manual therapy group (MTG) and home exercise group (HEG). Before treatment (T1), all patients were asked to fill out the Pittsburgh Sleep Quality Index (PSQI), Perceived Stress Scale (PSS), Fonseca Anamnestic Index (FAI), and Quality of Life Scale/Short Form-36 (SF-36), and additionally, the number of trigger points (NTP) and pain levels were determined.

Impact of Serum GDF-15 and IL-6 on Immunotherapy Response in Cancer: A Prospective Study.

Background: Immunotherapy has transformed cancer treatment; however, predicting treatment response remains challenging. Serum biomarkers can help identify patients who are most likely to benefit from immunotherapy.

Objective: This study evaluates the relationship between serum growth differentiation factor 15 (GDF-15) and interleukin-6 (IL-6) levels and treatment outcomes in cancer patients undergoing second-line immunotherapy.

Effect of propolis supplementation on cadmium toxicity associated with renal and hepatic dysfunction in rats.

Cadmium (Cd), one of the toxic heavy metals, is of great importance for public health due to its use in many industrial areas. Propolis is a natural product with antioxidant and anti-inflammatory properties collected from plants by honey bees. The aim of this study was to investigate the protective role of propolis against the potential toxic effects of cadmium chloride in blood, liver and kidney tissues.

Comprehensive Analysis of Elemental and Metabolite Composition in Boraginaceae Species from Türkiye.

Boraginaceae plants, including four endemic species from Türkiye, were analyzed for organic and inorganic compositions using ICP-MS and LC-MS/MS to explore their nutritional, medicinal, and ecological significance. This study examined 18 species, identifying key elements such as sodium (87,600.359-118,049.

Blood flow restriction combined with nordic hamstring exercise does not impair endothelial function but does not increase neuromuscular activation.

Background: Optimizing hamstring exercises is crucial for injury prevention and performance. This study explored the effects of blood flow restriction (BFR) during Nordic hamstring exercises (NHE) on hamstring muscle activation and vascular function.

Methods: A randomized, single-blind study included 14 healthy, physically active males (mean age: 27.

The cumulative effect of ellagic acid and carnosic acid attenuates oxidative events during diabetic wound healing: in different applications and on different days.

Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds ellagic acid and carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats.

Materials And Methods: Diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment groups.

Biochemical, Immunohistochemical, Histopathological, and Apoptotic Evaluation of Nickel Oxide Nanoparticle- and Microparticle-Induced Testicular Toxicity in Male Rats.

Nickel oxide nanoparticles are engineered particles that are now widely used in medicine, agriculture, and industry applications. This study aimed to investigate subchronic testicular toxicity induced by nickel oxide (NiO) and nickel oxide nanoparticles (NiONPs) in rats by comparing oral, intraperitoneal (IP), and intravenous (IV) routes of administration. Forty-two male Wistar rats were used for the study, and seven groups were formed: control group, NiO oral (150 mg/kg), NiO IP (20 mg/kg), NiO IV (1 mg/kg), NiONP oral (150 mg/kg), NiONP IP (20 mg/kg), and NiONP IV (1 mg/kg).

Development of Dermal Lidocaine Nanosuspension Formulation by the Wet Milling Method Using Experimental Design: In Vitro/In Vivo Evaluation.

Lidocaine (LID), frequently used in dermal applications, is a nonpolar local anesthetic agent that is practically insoluble in water. The main aim of this study is to develop the nanosuspension formulation of LID using the design of experiments (DoE). The improved solubility and dissolution rate provided by nanosizing are expected to result in enhanced dermal bioavailability.

Beginner-Level Tips for Medical Educators: Guidance on Selection, Prompt Engineering, and the Use of Artificial Intelligence Chatbots.

The integration of artificial intelligence (AI) chatbots, especially large language models (LLMs), holds significant potential for medical education. This article provides ten tips to help medical educators who have limited experience using LLM-based chatbots to support their teaching and assessment practices. These tips cover critical areas such as selecting appropriate models, employing prompt engineering techniques, and optimizing chatbot outputs to meet educational needs.

Predictive value of nutritional scores in non-valvular atrial fibrillation patients: Insights from the AFTER-2 study.

Background And Aim: Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems.

Methods And Results: A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study.

Review on critical factor in monocyte adhesion: Nutrients.

Endogenous and exogenous factors play a role in endothelial dysfunction. Inflammation, leukocyte adhesion-aggregation, abnormal vascular proliferation, atherosclerosis, and hypertension are among the endogenous factors. Another factor that affects endothelial dysfunction is exogenous factors such as drug treatments, smoking, alcohol, and nutrition.

Massive pulmonary thromboembolism in a pediatric patient with eosinophilic granulomatosis with polyangiitis: a case-based review emphasizing management.

Background: Pediatric patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA) are at an increased risk of arterial and venous thromboembolism (AVTE). Although the exact mechanisms underlying AVTE remain unclear, eosinophils play a pivotal role in AVTE.

Main Body: Current guidelines lack evidence-based recommendations, particularly concerning anticoagulant and antiplatelet treatments for this condition.

Similar Hepatitis B virus reactivation risk for patients with inflammatory arthritis or connective tissue diseases: a multicenter retrospective study.

Introduction: Hepatitis B reactivation and administration of prophylactic antiviral treatment are considered in patients with autoimmune inflammatory rheumatic diseases (AIIRD) undergoing immunosuppressive/immunomodulatory treatment. Data are more robust for rheumatoid arthritis patients receiving bDMARDs but are limited for other AIIRD and drug categories.

Methods: Adult patients with AIIRD (inflammatory arthritis [IA] or connective tissue diseases [CTD]) and documented chronic or resolved HBV infection (defined as serum HBsAg positivity or anti-HBcAb positivity in the case of HBsAg non-detection respectively), followed-up in six rheumatology centers in Greece and Italy, were included.

Postural balance impairment following arthroscopic rotator cuff repair in the early postoperative period: a prospective cohort study.

Background: For patients undergoing arthroscopic rotator cuff repair surgery (RCR), it is crucial to prevent falls to minimize the risk of re-tearing the repaired muscles. Shoulder immobilization during the postoperative period may lead to a decline in postural balance. This prospective cohort study aimed to investigate the postural balance of patients in the early postoperative period following arthroscopic RCR.

Prevalence and Predictive Features of CT-Derived Nonalcoholic Fatty Liver Disease in Metabolically Healthy MACS.

Objective: Patients with mild autonomous cortisol secretion (MACS) are at increased risk of cardiometabolic outcomes, such as hyperglycemia, metabolic syndrome, and cardiovascular diseases. Nonalcoholic fatty liver disease (NAFLD) is also associated with increased cardiometabolic risk. We aimed to investigate the prevalence and predictors of NAFLD in metabolically healthy subjects with MACS.

Middle-Aged and Young People's Perspectives on Healthy Aging Through Exercise: Environmental, Psychosocial, and Individual Factors With the Photovoice Method.

The aim of this study is to examine the individual's perspective on healthy aging through exercise. Individuals aged 18-60 years who have been physically active for at least one year were included in this study. The study focused on the exercise behaviors of young and middle-aged individuals through photographs.

Systematic literature review and meta-analysis informing the EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer.

Background: Targeted therapies have been associated with potential risk of malignancy, which is a common concern in daily rheumatology practice in patients with inflammatory arthritis (IA) and a history of cancer.

Objectives: To perform a systematic literature review to inform a Task Force formulating EULAR points to consider on the initiation of targeted therapies in patients with IA and a history of cancer.

Methods: Specific research questions were defined within the Task Force before formulating the exact research queries with a librarian.

2024 EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer.

Background: Potential associations between targeted therapies and a new cancer in patients with inflammatory arthritis (IA) and a previous malignancy are a frequent concern in daily rheumatology practice.

Objectives: To develop points to consider (PTC) to assist rheumatologists when initiating a targeted therapy in the context of a previous malignancy.

Methods: Following EULAR standardised operating procedures, a task force met to define the research questions for a systematic literature review and to formulate the overarching principles (OPs) and the PTC.

The impact of "nurse-led education" vs. "nurse-led education plus peer support" on patients' decision for peritoneal dialysis treatment in chronic kidney disease patients.

Introduction: End-stage kidney disease patients face a critical decision regarding kidney replacement therapy options, which include kidney transplantation, hemodialysis, or peritoneal dialysis (PD). This study aims to evaluate the impact of nurse-led education (NE) alone vs. NE combined with peer support on the patients' decision over PD treatment in chronic kidney disease patients.

Outcome of Soft Tissue Popliteal Sarcomas: 15 Years of Experience.

Background: Soft-tissue sarcoma involving the popliteal fossa remains challenging because it is difficult to achieve wide margins with limb salvage in this location. Adjuvant therapy is frequently necessary, and limb function can be adversely affected. We reviewed our experience with these tumors.