5 results match your criteria: "Gates Hillman Center[Affiliation]"
Longitudinal patient-reported outcomes and survival among early-stage non-small cell lung cancer patients receiving stereotactic body radiotherapy.
Radiother Oncol
February 2022
Department of Radiation Oncology, Moffitt Cancer Center, USA; Department of Thoracic Oncology, Moffitt Cancer Center, USA. Electronic address:
Background And Purpose: The study objective was to determine whether longitudinal changes in patient-reported outcomes (PROs) were associated with survival among early-stage, non-small cell lung cancer (NSCLC) patients undergoing stereotactic body radiation therapy (SBRT).
Materials And Methods: Data were obtained from January 2015 through March 2020. We ran a joint probability model to assess the relationship between time-to-death, and longitudinal PRO measurements.
Systems Imaging of the Immune Synapse.
Methods Mol Biol
February 2018
School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Three-dimensional live cell imaging of the interaction of T cells with antigen-presenting cells (APCs) visualizes the subcellular distributions of signaling intermediates during T cell activation at thousands of resolved positions within a cell. These information-rich maps of local protein concentrations are a valuable resource in understanding T cell signaling. Here, we describe a protocol for the efficient acquisition of such imaging data and their computational processing to create four-dimensional maps of local concentrations.
View Article and Find Full Text PDFHIV-1 Capsid Function Is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD.
J Am Chem Soc
October 2016
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its assembly into conical capsids and interactions with host factors. CA is dynamic in the assembled capsid, and residues in functionally important regions of the protein undergo motions spanning many decades of time scales. Chemical shift anisotropy (CSA) tensors, recorded in magic-angle-spinning NMR experiments, provide direct residue-specific probes of motions on nano- to microsecond time scales.
View Article and Find Full Text PDFThe autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment.
Nat Commun
March 2015
1] Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA [2] Kavli Institute for Neuroscience, Yale School of Medicine, PO Box 208001, New Haven, Connecticut 06520, USA.
Article Synopsis
- Recent research shows that chromatin modifiers, particularly CHD8, are linked to autism spectrum disorder (ASD) through common mutations found in individuals with the condition.
- ASD risk genes are co-expressed in the midfetal human cortex, indicating they work together in specific regulatory networks during brain development.
- Knocking down CHD8 in human neural stem cells disrupts these ASD risk genes, suggesting that loss of CHD8 affects key regulatory networks involved in ASD.
A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors.
BMC Biophys
June 2012
Computer Science Department, Carnegie Mellon University, Gates Hillman Center, 5000 Forbes Avenue, Pittsburgh, PA, USA.
Background: G protein coupled receptors (GPCRs) are seven helical transmembrane proteins that function as signal transducers. They bind ligands in their extracellular and transmembrane regions and activate cognate G proteins at their intracellular surface at the other side of the membrane. The relay of allosteric communication between the ligand binding site and the distant G protein binding site is poorly understood.
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