542 results match your criteria: "Gastrointestinal Cancer Center[Affiliation]"

Dysregulated epigenetic programs that restrict differentiation, reactivate fetal genes, and confer phenotypic plasticity are critical to colorectal cancer (CRC) development. By screening a small molecule library targeting epigenetic regulators using our dual reporter system, we found that inhibiting histone deacetylase (HDAC) 1/2 promotes CRC differentiation and anti-tumor activity. Comprehensive biochemical, chemical, and genetic experiments revealed that on-target blockade of the HDAC1/2 catalytic domain mediated the differentiated phenotype.

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Background: Total mesorectal excision is the standard surgery for locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT), but it may lead to high complication rates and poor quality of life. This study evaluates whether transanal endoscopic microsurgery (TEM), as a partial resection procedure, can enhance quality of life for clinical complete response (cCR) or near-cCR patients without compromising survival.

Methods: Between May 2017 to September 2021, 80 patients with T3-4N0M0 or TanyN+M0 mid-low rectal cancer achieving cCR or near-cCR post-nCRT were prospectively included at 6 Chinese centers.

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Background: There is currently limited research on the optimal level of inferior mesenteric artery (IMA) ligation during surgery for patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (nCRT). We carried out a retrospective cohort study to analyze the impact of IMA ligation level on surgical outcomes and long-term patient prognosis.

Methods: The data originated from a multicenter randomized controlled trial conducted across six tertiary referral hospitals in Beijing, involving patients with LARC undergoing nCRT followed by radical surgery.

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Specifying the Associations between PM Constituents and Gastrointestinal Cancer Incidence: Findings from a Prospective Cohort Study in Beijing, China.

Environ Sci Technol

December 2024

State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management, Center for Environment and Health, Peking University, Beijing 100871, China.

This study aimed to test the association between PM and the incidence of gastrointestinal (GI) cancer, and further to detect the primary constituents on this association. A sum of 142,982 participants without GI cancer at baseline were derived from the National Urban Cancer Screening Program in Beijing (2013-2019). The 5 year averaged concentrations of PM mass and its five constituents, namely, black carbon (BC), ammonium (NH), nitrate (NO), organic matter (OM), and inorganic sulfate (SO), were estimated by using a hybrid machine learning model.

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The clinical significance of FOLFOXIRI (5-FU, leucovorin, oxaliplatin, and irinotecan) plus anti-EGFR monoclonal antibody using cetuximab for metastatic colorectal cancer (mCRC) remains controversial. We report results from a randomized phase 2 DEEPER trial (UMIN000018217, jRCTs061180022) to test the superiority of modified (m)-FOLFOXIRI plus weekly cetuximab over bevacizumab in patients with RAS wild-type (wt) mCRC. Primary endpoint was depth of response (DpR).

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Global burden of disease attributable to metabolic risk factors in adolescents and young adults aged 15-39, 1990-2021.

Clin Nutr

December 2024

MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address:

Background: Metabolic risk factors are a significant cause of global burden among adolescents and young adults, but there is a lack of attention to the burden attributable to these metabolic risk factors globally.

Aims: This study aims to provide comprehensive estimates of five important metabolic risk factors and the attributable disease burden in people aged 15-39 years from 1990 to 2021, based on the Global Burden of Disease Study (GBD) database.

Methods: Global total deaths and disability-adjusted life years (DALYs) were used to describe the burden attributable to five common metabolic risk factors, including high fasting plasma glucose (FPG), high low-density lipoprotein cholesterol (LDL-C), high systolic blood pressure (SBP), high body mass index (BMI), and kidney dysfunction, in adolescents and young adults.

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Improved anaerobic digestion of food waste under ammonia stress by side-stream hydrogen domestication.

Water Res

January 2025

Key laboratory of the Three Gorges Reservoir Region's Eco-environments, Ministry of Education, Institute of Environment and Ecology, Chongqing University, 174 Shapingba Road, Chongqing, 400045, PR China.

High ammonia concentration inhibits archaea's activity, causing the accumulation of H and acetate, which suppresses methane production in anaerobic digestion (AD). The study aimed to enhance microbial hydrogen metabolism through a side-stream hydrogen domestication (SHD) strategy, which involves applying hydrogen stimulation to a portion of the sludge separately. SHD maintained a stable methane yield of 407.

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Background: Laparoscopic surgery is increasingly used for rectal cancer, but the long-term oncological outcomes for low rectal cancer have not been fully established. We aimed to evaluate the 3-year survival outcomes of laparoscopic surgery versus open surgery in the treatment of low rectal cancer.

Methods: This multicentre, randomised, controlled, non-inferiority trial was conducted at 22 tertiary hospitals in China.

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Endoscopic morphology of gastric MALT lymphoma correlate with API2/MALT1 fusion and predict treatment response after helicobacter pylori eradication.

BMC Gastroenterol

October 2024

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu, 610041, Sichuan, China.

Background: The presence of API2/MALT1 fusion in gastric mucosa-associated lymphoid tissue (MALT) lymphoma predicts poor response to Helicobacter pylori (Hp) eradication therapy. This study aimed to assess the correlation between endoscopic morphology of MALT lymphoma and API2/MALT1 fusion and evaluate treatment response to Hp eradication based on morphological subtypes.

Methods: A retrospective review was conducted on patients diagnosed with gastric MALT lymphoma between January 2011 and December 2022.

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Enhance Fe(III) reduction in sludge fermentation for vivianite formation using exogenous H assisted by activated carbon.

Water Res

January 2025

Key laboratory of the Three Gorges Reservoir Region's Eco-environments, Ministry of Education, Institute of Environment and Ecology, Chongqing University, 174 Shapingba Road, Chongqing, 400045, China.

Vivianite, a notable secondary mineral formed through dissimilatory iron reduction (DIR), demonstrates great potential in addressing both eutrophication and phosphorus deficiency. However, the presence of competition for electrons from the methanogenic pathway and the low rates of Fe(III) reduction limit the creation of vivianite. In this research, H was utilized as electron donor assisted by activated carbon (AC) to promote Fe(Ⅲ) reduction with FePO as electron acceptors.

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Lymph node metastasis of intrahepatic cholangiocarcinoma: the present and prospect of detection and dissection.

Eur J Gastroenterol Hepatol

December 2024

Department of Hepatobiliary Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Intrahepatic cholangiocarcinoma (ICC) ranks as the second most primary liver cancer that often goes unnoticed with a high mortality rate. Hepatectomy is the main treatment for ICC, but only 15% of patients are suitable for surgery. Despite advancements in therapeutic approaches, ICC has an unfavorable prognosis, largely due to lymph node metastasis (LNM) that is closely linked to the elevated recurrence rates.

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Metabolomics Analysis for Unveiling the Toxicological Mechanism of Silver Nanoparticles Using an Gastrointestinal Digestion Model.

ACS Nanosci Au

October 2024

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Article Synopsis
  • * A simulated digestion model was used to study how the physicochemical properties of AgNPs change during digestion and to explore their toxic effects on intestinal cells through metabolomics analysis.
  • * Results indicate that conditions in the GIT, including acidity and the presence of digestive enzymes, can enhance Ag uptake by gut cells, leading to oxidative stress and potential cell damage, with implications for understanding the health risks associated with AgNPs.
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Management of non-alcoholic fatty liver disease-associated hepatocellular carcinoma.

Biosci Trends

November 2024

Department of Hepatobiliary Pancreatic Cancer Center, Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China.

In recent years, with the decline in HBV and HCV infections, there has been a corresponding reduction in both the morbidity and mortality of virus-associated HCC. Nevertheless, rising living standards, coupled with the increasing prevalence of metabolic disorders like diabetes and obesity, have led to a rapid surge in non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC) incidence. The mechanisms underlying the progression from NAFLD to NAFLD-HCC are multifaceted and remain incompletely understood.

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Article Synopsis
  • Inadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients leads to higher local recurrence rates, but LLN dissection (LLND) may help reduce this risk.
  • This study will evaluate the outcomes of a standardized treatment approach after multidisciplinary training, aiming for a 50% reduction in local recurrence rates among patients with rectal cancer and enlarged LLNs.
  • The trial involves 200 patients and will assess important outcomes such as local recurrence rates, morbidity, disease-free survival, and quality of life over three years post-surgery, with ethical approval from a Dutch medical ethics board.
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Exploring the impact of durvalumab on biliary tract cancer: insights from real-world clinical data.

Cancer Immunol Immunother

October 2024

Department of Internal Medicine I for Hematology With Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz, Austria.

Article Synopsis
  • This study evaluates the use of durvalumab combined with platinum and gemcitabine for treating biliary tract cancers, aiming to validate previous trial results in a real-world setting and investigate how molecular profiles may affect patient outcomes.* -
  • The analysis involved 102 patients from multiple cancer centers, revealing a 71.57% disease control rate and a median overall survival of 13.61 months, with younger patients showing better outcomes.* -
  • Findings indicate that while no specific molecular profiles predicted better responses to durvalumab, patients receiving tailored second-line therapy showed a potential survival advantage, highlighting the need for further research in this area.*
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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver.

Sci China Life Sci

January 2025

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, Beijing, 100142, China.

Extrachromosomal DNA (ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution.

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Tumor-infiltrating immune cell profiles and changes associate with additional trastuzumab in preoperative chemotherapy for patients with HER2-positive gastric cancer.

Br J Cancer

November 2024

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, 100142, Beijing, China.

Article Synopsis
  • HER2(+) gastric cancer patients can potentially benefit from the addition of trastuzumab in treatment, but its effects on immune cells were previously unclear.
  • A study analyzing immune cell profiles in over 1,300 patients found significant differences in T cell infiltration between HER2(+) and HER2(-) gastric cancer, with trastuzumab improving immune responses in treated patients.
  • The findings suggest that trastuzumab not only influences cancer treatment outcomes but may also enhance the immune environment, supporting further exploration of combined immunotherapy strategies for these patients.
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Article Synopsis
  • * Among 190 patients evaluated, 32.1% tested positive for ctDNA post-surgery; adjuvant chemotherapy (ACT) significantly improved disease-free survival (DFS) for MRD-positive patients, while it showed no advantage for MRD-negative patients.
  • * Key findings indicate that the size of liver metastases correlates with DFS in MRD-positive patients, emphasizing the importance of MRD status in guiding treatment decisions post-surgery.
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CD24-Targeted NIR-II Fluorescence Imaging Enables Early Detection of Colorectal Neoplasia.

Cancer Res

December 2024

CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Article Synopsis
  • - Colorectal cancer remains a significant health challenge despite improved screening techniques, as traditional methods like white-light colonoscopy often miss flat lesions that can lead to advanced tumors.
  • - A new near-infrared fluorescent probe targeting CD24 has been developed, showing high sensitivity (92%) and specificity (92%) for detecting colorectal cancer, including small lesions under 1 mm, which are typically overlooked.
  • - This study's results suggest that CD24-targeted NIR-II imaging could greatly enhance early detection of colorectal cancer during procedures like colonoscopy, potentially identifying precancerous lesions that other methods fail to see.
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ctDNA-based molecular residual disease and survival in resectable colorectal cancer.

Nat Med

November 2024

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

The interim analysis of the CIRCULATE-Japan GALAXY observational study demonstrated the association of circulating tumor DNA (ctDNA)-based molecular residual disease (MRD) detection with recurrence risk and benefit from adjuvant chemotherapy (ACT) in resectable colorectal cancer (CRC). This updated analysis with a 23-month median follow-up, including 2,240 patients with stage II-III colon cancer or stage IV CRC, reinforces the prognostic value of ctDNA positivity during the MRD window with significantly inferior disease-free survival (DFS; hazard ratio (HR): 11.99, P < 0.

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Neoadjuvant Immunotherapy Alone for Patients With Locally Advanced and Resectable Metastatic Colorectal Cancer of dMMR/MSI-H Status.

Dis Colon Rectum

November 2024

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Cancer Center, Unit III, Peking University Cancer Hospital and Institute, Beijing, China.

Background: The use of programmed death-1 blockade has a significant therapeutic effect in patients with mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer. However, data on preoperative single-agent programmed death-1 blockade are rare.

Objective: This study aims to evaluate the effectiveness and safety of preoperative programmed death-1 blockade as a conversion strategy in patients with locally advanced and resectable metastatic mismatch repair-deficient/microsatellite instability-high colorectal cancer.

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